A5064924981- Optimization and Variational Analysis
- Fixed Point Theorems Analysis
- Advanced Optimization Algorithms Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Nonlinear Differential Equations Analysis
- Bone and Dental Protein Studies
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Point processes and geometric inequalities
- Ferroptosis and cancer prognosis
- Geometric Analysis and Curvature Flows
- Advanced Banach Space Theory
- Pancreatic and Hepatic Oncology Research
- Nonlinear Partial Differential Equations
- Sarcoma Diagnosis and Treatment
- Contact Mechanics and Variational Inequalities
- Analytic and geometric function theory
- Uterine Myomas and Treatments
- Renal cell carcinoma treatment
- Advanced Differential Geometry Research
- Differential Equations and Boundary Problems
Toho University
2016-2025
Nagoya Central Hospital
2010-2018
Johns Hopkins University
2015
Kyoto Prefectural University of Medicine
2006-2013
Tokyo Institute of Technology
2003-2011
Sysmex (Japan)
2011
Chiba University
2011
Japanese Red Cross Nagoya Daiichi Hospital
2010
Nagoya University
2010
Osaka University
2007-2010
The podosome and invadopodium are dynamic cell‐adhesion structures that degrade the extracellular matrix (ECM) promote cell invasion. We recently reported actin‐binding protein caldesmon is a pivotal regulator of formation. Here, we analyzed caldesmon's involvement in podosome/invadopodium‐mediated invasion by transformed cancer cells. ectopic expression reduced number podosomes/invadopodia decreased ECM degradation activity, resulting suppression Conversely, depletion facilitated formation...
The convex optimization problems have been considered by many researchers on geodesic spaces. In these problems, the resolvent operators play an important role. this paper, we propose new resolvents spaces, and show that they better properties than other known operators.
Myocardin is an important transcriptional regulator in smooth and cardiac muscle development. We noticed that the expression of myocardin was markedly downregulated human uterine leiomyosarcoma cells. Restoration induced reexpression marker proteins formation well-developed actin fibers. A concomitant increase a cyclin-dependent kinase inhibitor, p21, led to significantly reduced cell proliferation, via p21's inhibition G(1)-S transition. p21 promoter-reporter assay showed increased promoter...
Prostate cancer is a leading cause of death in men due to the subset cancers that progress metastasis. are thought be hardwired androgen receptor (AR) signaling, but AR-regulated changes prostate facilitate metastasis remain poorly understood. We previously noted marked reduction secreted protein, acidic and rich cysteine-like 1 (SPARCL1) expression during invasive phases androgen-induced growth, suggesting this may novel program governed by AR. Herein, we show SPARCL1 loss occurs...
The radiologic and endoscopic findings in six patients with anisakiasis of the colon were analyzed. diagnosis was based on demonstration Anisakis larvae at radiography or elevated serum levels antibodies to this parasite. All reported abdominal symptoms 12-23 hours after ingestion raw fish. Double-contrast barium enema examination, performed 2-4 days onset syptoms all patients, revealed that right side frequently affected by edema, which radiographically demonstrated as luminal narrowing...
Gastric venous congestion and bleeding in association with total pancreatectomy (TP) were evaluated.Thirty-eight patients of TP retrospectively analyzed. was classified as distal gastrectomy (TPDG), pylorus-preserving (PPTP), subtotal stomach-preserving (SSPTP), segmental duodenectomy (TPSD).Portal vein or superior mesenteric resection reconstruction performed 24 (62.2%). occurred immediately after tumor one eight who underwent SSPTP, urgent anastomosis between the right gastroepiploic left...
We study a sequence of generalized projections in reflexive, smooth, and strictly convex Banach space. Our result shows that Mosco convergence their ranges implies pointwise to the projection onto limit set. Moreover, using this result, we obtain strong weak resolvents for maximal monotone operators.
Abstract The purpose of this paper is to prove two Δ-convergence theorems the Mann algorithm a common fixed point for countable family mappings in case complete geodesic space with curvature bounded above by positive number. first one nonexpansive improves recent result He et al. (Nonlinear Anal. 75:445-452, 2012). last proved quasi-nonexpansive and applied problem finding mappings. MSC: 49J53.
To predict application performance on an HPC system is important technology for designing the computing and developing applications. However, accurate prediction a challenge, particularly, in case of future coming with higher performance. In this paper, we present new method predicting systems. This combines modeling sequential single processor macro-level simulations applications parallel entire system. simulation, execution flow traced but kernel computations are omitted reducing time....
We propose a new concept of set convergence in Hadamard space and obtain its equivalent condition by using the notion metric projections. Applying this result, we also prove theorem for an iterative scheme shrinking projection method real Hilbert ball.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is endogenously expressed in immune cells and contributes to immunosurveillance for cancer. TRAIL induces apoptosis preferentially various cancer cells, including renal cell carcinoma (RCC) cells. In this study, the serum level was examined using an enzyme-linked immunosorbent assay 52 healthy controls 84 RCC patients prior surgery its significance as a biomarker evaluated. The median lower compared (55.9 vs. 103.1 pg/ml;...
In this paper, we deal with the Halpern iterative scheme for a strongly quasinonexpansive mapping in setting of complete geodesic space curvature bounded above by one. Our result can be applied to image recovery problem. We also consider approximation fixed point nonexpansive and obtain convergence theorems, one which is supplement Pia̧tek an additional sufficient condition. MSC:47H09.
Metastasis is a consequence of many biological events, during which cancer stem cells are shifted into malignant state. Among these invasion prostate host tissues possible to be assessed by means an in vitro model, and thought coupled altered expression membrane proteins. Dysregulated functions the factors regulating organogenesis embryogenesis known facilitate metastasis types cancers. PAX2 (paired box 2) member PAX transcription factor family, regulates prostatic ductal growth branching...
In this paper, we obtain an equivalent condition to the existence of a common fixed point given family nonexpansive mappings defined on Hadamard space. Moreover, if space is bounded, show that generating process approximate sequence by specific projection method will stop in finite steps there no point. It significant advantage reveal nonexistence time.
Early ligation of the inferior pancreatoduodenal artery has been advocated to reduce blood loss during pancreatoduodenectomy. However, impact early dorsal pancreatic (DPA) remains unclear. This study was performed investigate clinical implications DPA.From October 2014 April 2017, 34 consecutive patients underwent pancreatoduodenectomy using a mesenteric approach. The were divided into DPA group (n = 15) and late 19). features retrospectively compared between two groups...