Graphite oxide was found to be a highly efficient, reusable and cost-effective heterogeneous catalyst for the direct metal-free transformation of amines afford corresponding imines under mild neat conditions with molecular oxygen as terminal oxidant. This method is simple, economic environmentally benign, resulting in practical advantages convenient synthesis their derivatives.

Phenol-menal: Bis zu 100 g von neuartigen Imidazol-Phosphan-Liganden wurden nach einem bequemen Lithiierungs-Phosphorylierungs-Protokoll synthetisiert. Die luft- und feuchtigkeitsbeständigen Phosphane erwiesen sich in der palladiumkatalysierten selektiven Hydroxylierung Arylhalogeniden als erfolgreich (siehe Schema, dba = Dibenzylidenaceton).

In three steps to ruthenium-based heterogeneous catalysts: The central element of this novel and simple route is the immobilization Ru0 nanoparticles on montmorillonite (see picture; arrows indicate a Ru nanoparticle intercalated in interlaminar space montmorillonite) with help an ionic liquid. resulting catalyst highly efficient for hydrogenation benzene.

Developing new efficient catalytic systems to convert abundant and renewable feedstocks into valuable products in a compact, flexible, target-specific manner is of high importance modern synthetic chemistry. Here, we describe versatile set mild conditions utilizing single gold-based solid catalyst that enables the direct additive-free preparation four distinct important amine derivatives (amines, formamides, benzimidazoles, dimethlyated amines) from readily available formic acid (FA) nitro...

Selective defluorinative functionalization of trifluoromethyl group (-CF3) is an attractive synthetic route to the pharmaceutically privileged fluorine-containing moiety. Herein, we report a strategy based on photoexcited copper catalysis activate C-F bond di- or trifluoromethylated arenes for divergent radical C-N coupling with carbazoles and aromatic amines. The use different ligands can tune reaction products diversity. A range substituted, structurally diverse α,α-difluoromethylamines be...

Well matched: Novel palladium/heteroaryl-phosphines are introduced for Sonogashira reactions of aryl and heteroaryl chlorides including challenging substrates (see scheme). The desired coupling proceed smoothly tolerate various functional groups. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: publisher is responsible content...

A porous copolymer of an IL with divinylbenzene was prepared and applied as a support for Pd nanoparticles. The supported nanocatalyst found to be extremely active Suzuki-Miyaura reaction aryl bromides chlorides phenylboronic acid even 10 ppm loading under air in water.

The asymmetric total synthesis of (+)-waihoensene, which has a cis-fused [6,5,5,5] tetracyclic core bearing an angular triquinane, six-membered ring, and four contiguous quaternary carbon atoms, was achieved through sequence chemical reactions in stereochemically well-defined manner. features the following: (1) Cu-catalyzed conjugated 1,4-addition; (2) diastereoselective Conia-ene type reaction; (3) intramolecular Pauson–Khand (4) Ni-catalyzed (5) radical-initiated hydrogen atom transfer...

Abstract Efficient total syntheses of the naturally occurring, potent antibiotic compounds (−)‐crinipellin A and B are described. The key advanced intermediate, a fully functionalized tetraquinane core, was constructed by novel thiourea/palladium‐catalyzed Pauson–Khand reaction. This intermediate can serve as common for collective synthesis other members crinipellin family.

The direct one-pot reductive imination of nitroarenes with various aldehydes by a titania supported gold catalyst at room temperature using CO/H2O as reducing agent is illustrated. This method simple, economic, general and environmentally benign, thus resulting in practical advantages for the synthesis imines their derivatives.

Abstract Highly enantioselective Michael addition of acetone to a variety nitroalkenes promoted by simple chiral primary amine bifunctional catalysts (e.g., Noyori's Ts‐DPEN ligand) together with terephthalic acid in excellent yields (84–99 %) and enantioselectivities (93–98 % ee ) is reported.

Wind power has emerged as a prominent method of new energy generation in recent years. As the efficiency generator operation becomes increasingly critical, maintenance these generators come into focus. turbines are often located areas with high wind availability, and establishing warehouses for spare parts storage at sites can substantially decrease both time costs. However, longevity be compromised by soft failures, such corrosion, which diminish their service life. This paper explores...

Regio- and stereoselective photoredox-catalyzed cyclizations of alkene-substituted β-ketoesters have been accomplished for the synthesis polyfunctionalized cyclopentanones. This was achieved using 2,3,5,6-tetrakis(carbazol-9-yl)-1,4-dicyanobenzene (4CzTPN) 2,4,6-triisopropyl-thiophenol as cocatalysts under illumination a blue-light-emitting-diode at ambient temperature. The developed chemistry successfully applied in enantioselective total tricyclic prostaglandin D2 metabolite...

The presence of sterically rigid contiguous quaternary stereocenters in natural products imposes conformational constraints with significant effects on their biological activities. However, achieving the direct synthesis multiple a single step remains formidable challenge. Here, we present total antibacterial metabolite lugdunomycin (1) thirteen steps via sequence photochemical transformations. A photoenolization, keto–enol tautomerization, and spiroketalization was developed to generate...

An asymmetic total synthesis of (+)-fusarisetin A has been achieved. The essential to our strategy was the application intramolecular Pauson–Khand reaction for stereoselective construction trans-decalin subunit with a unique C16 quarternary chiral center. developed chemistry offers an alternative IMDA that used fusarisetin A, and is applicable analogue biological evaluation.

The total synthesis of naturally occurring (±)-sinensilactam A was achieved in 18 steps. key steps this work are a rhodium-catalyzed [3 + 2] cycloaddition for construction the two all-carbon vicinal quaternary centers and convergent tandem condensation situ generated N-acyliminium intermediate with aldehyde 20. This enabled implementation unified strategy stereoselective formation tetracyclic hemiaminal core sinensilactam later stage. syntheses applanatumol F C8-epi-applanatumol D also using...

A convenient enantioselective total synthesis of (+)-cyclobutastellettolide B via a strategy that involves diastereoselective Johnson-Claisen rearrangement, regioselective cyclopropoxytrimethylsilane ring-opening reaction, and Norrish-Yang cyclization is described. The results computational experimental studies indicate the regio- stereoselectivity reaction are controlled by C-H bond dissociation energy restricted rotation C13-C14 bond.

A unified strategy toward the asymmetric facile construction of [6.7.6.5]oxapentacyclic skeleton cortistatins is reported, featuring intramolecular Diels-Alder (IMDA), oxidative dearomatization, and an oxy-Michael addition reaction.

Asymmetric total syntheses of nannocystins A and A0 were achieved in a convergent route starting from simple materials. Nannocystin family natural products bear potent anticancer activity as elongation factor 1 inhibitors. In this synthesis, the challenging tertiary amide bond was constructed by peptide coupling between an acyl chloride secondary amine. late-stage ring-closing metathesis reaction successfully rendered macrocycle. This efficient synthetic strategy should be applicable to...

Abstract Homodimericin A is a remarkable fungal metabolite. This highly oxygenated racemic unsaturated polyketide poses significant synthetic challenge owing to its sterically demanding central cagelike core containing eight contiguous stereogenic centers (including three quaternary stereocenters) and several carbonyl functionalities. On the basis of proposed biogenetic synthesis, we designed total synthesis homodimericin that proceeds in seven steps features double Michael reaction, an...

Photoredox-catalyzed isomerization of γ-carbonyl-substituted allylic alcohols to their corresponding carbonyl compounds was achieved for the first time by C-H bond activation. This catalytic redox-neutral process resulted in synthesis 1,4-dicarbonyl compounds. Notably, bearing tetrasubstituted olefins can also be transformed into Density functional theory calculations show that group at γ-position are beneficial formation alcohol radicals with high vertical electron affinity, which...