A5074468938- Pesticide Exposure and Toxicity
- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- Pharmaceutical and Antibiotic Environmental Impacts
Guy's Hospital
2021-2022
King's College London
2021-2022
The toxicity of co-formulants present in glyphosate-based herbicides (GBHs) has been widely discussed leading to the European Union banning polyoxyethylene tallow amine (POEA). We identified most commonly used POEA, known as POE-15 (POE-15), US GBH RangerPro. Cytotoxicity assays using human intestinal epithelial Caco-2 and hepatocyte HepG2 cell lines showed that RangerPro are far more cytotoxic than glyphosate alone. but not caused necrosis both lines, oxidative stress cells. further tested...
1. Mesnage R, Zaller JG. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier, RTI Press; 2021. Google Scholar
Commercial pesticide formulations contain co-formulants, which are generally considered as having no toxic effects in mammals. This study aims to compare the toxicity of 8 major herbicide active ingredients–namely glyphosate, dicamba, 2,4-D, fluroxypyr, quizalofop-p-ethyl, pendimethalin, propyzamide and metazachlor–with a typical commercial formulation each ingredient. Cytotoxicity oxidative stress capability was assessed human hepatoma HepG2 cells. Using an MTT assay, glyphosate (Roundup...
Abstract Understanding the nature of co-formulants and toxic effects major glyphosate-based herbicide (GBH) formulations is considered a research priority. Indeed, toxicity present in GBHs have been widely discussed European Union recently banned co-formulant polyoxyethylene tallow amine (POEA). We provide foundation for development new environmental epidemiological studies by reporting presence most commonly used POEA, known as POE-15 amine, US GBH RangerPro. In order to understand if...