A5074993815- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Cardiovascular and exercise physiology
- Family and Patient Care in Intensive Care Units
- Cardiac Ischemia and Reperfusion
- Palliative Care and End-of-Life Issues
- Metabolomics and Mass Spectrometry Studies
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Electrolyte and hormonal disorders
- Ultrasound in Clinical Applications
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2021-2025
Metropolitana Milanese (Italy)
2023-2024
University of Milano-Bicocca
2017-2022
Zero to Three
2021
Ospedale Maggiore
2020
Azienda Ospedaliera San Gerardo
2017
The present analysis from the multicentre prospective Altshock-2 registry aims to better define clinical features, in-hospital course, and management of cardiogenic shock complicating acutely decompensated heart failure (ADHF-CS) as compared with that acute myocardial infarction (AMI-CS).All patients AMI-CS or ADHF-CS enrolled in between March 2020 February 2022 were selected. primary objective was characterization AMI-CS. In-hospital length stay mortality secondary endpoints....
Introduction The treatment of patients with cardiogenic shock (CS) has been focused historically on single interventions (medical treatments, percutaneous and surgical and, more recently, various temporary mechanical circulatory supports). However, none these significantly changed the short-term prognosis CS. Moreover, considerable interest in applied acute setting not matched comprehensive assessment patients’ long-term follow-up, only for survival rehospitalisation but also quality life...
Extracorporeal cardiopulmonary resuscitation is increasingly recognised as a rescue therapy for refractory cardiac arrest, nevertheless data are scanty about its effects on neurologic and outcome. The aim of this study to compare clinical outcome in patients with arrest ischaemic origin (i.e. critical coronary plaque during angiography) return spontaneous circulation conventional vs needing extracorporeal resuscitation. Moreover, we tried identify predictors survival after successful...
Cardiac rehabilitation (CR) is an effective tool for secondary prevention after acute coronary syndrome (ACS). Aim of our study was to find the significant determinants exercise capacity (evaluated with six-minute walking test—6-MWT) and functional improvement in patients undergoing CR ACS. The group included 298 (mean age 61.6 ± 10.2 years; males 80.2%) who, ACS, were enrolled program at Niguarda Hospital Milan from 2015 2018. For all patients, we collected anamnestic, clinical instrumental...
Systemic capillary leak syndrome (SCLS) is a potentially fatal disorder characterized by relapses of hypovolemic shock episodes.We present case 58-year-old man who presented to the Emergency Department with history recurrent episodes syncope in last hours. A few days before medical contact patient complained sore throat, fever, and flu-like symptoms. He was initially admitted diagnosis suspected myopericarditis. Forty-eight hours later, haemodynamic status suddenly deteriorated mixed...
Tachycardia and rapid tachyarrhythmias are common in acute clinical settings may hasten the deterioration of haemodynamics patients with decompensated heart failure (ADHF), treated inotropes. The concomitant use a short-acting β1-selective beta-blocker, such as landiolol, could rapidly safely restore an adequate rate without any negative inotropic effect. We present case series five left ventricular dysfunction, admitted to our Intensive Cardiac Care Unit ADHF deteriorated cardiogenic shock,...
Garatti, Laura; Tavecchia, Giovanni; Milani, Martina; Rizzi, Ilaria; Tondelli, Daniele; Bernasconi, Davide; Maloberti, Alessandro; Oliva, Fabrizio; Sacco, Alice Author Information
Abstract Aims Hypoperfusion portends adverse outcomes in acute heart failure (AHF). The gradient between end-organ inflow and outflow pressures may more closely reflect hypoperfusion than mean arterial pressure (MAP) alone. aim of this study was to investigate organ perfusion (OPP), calculated as MAP minus central venous (CVP), a prognostic marker AHF. Methods results Sodium NItroPrusside Treatment Acute Heart Failure (SNIP)-AHF multicentre retrospective cohort 200 consecutive patients...
Patients with advanced heart failure (HF) experience a continuous decline in quality of life and have very poor prognosis. Moreover, due to numerous comorbidities present these patients, transplantation left ventricular assist devices are usually impracticable clinical practice. In this challenging setting, administration inotropic agents may be the only possible therapy; however, treatment requires frequent hospitalizations. Our hypothesis is that sacubitril/valsartan, given its marked...
The optimal timing of PCI for NSTE-ACS with CKD is unclear. aim our study was to assess whether early percutaneous coronary intervention (PCI) (within 24 hours from admission) associated improved in-hospital (mortality or acute kidney injury) and long-term events (composite mortality, myocardial infarction, stroke bleeding events) in patients non-ST-elevation syndromes (NSTE-ACS) chronic disease (CKD).We retrospectively studied who underwent large tertiary centers. defined as estimated...
Abstract Background Hypoperfusion portends adverse outcomes in acute heart failure (AHF). The gradient between end-organ inflow and outflow pressures may more closely reflect hypoperfusion than mean arterial pressure (MAP) alone. Purpose To investigate organ perfusion (OPP), calculated as MAP minus central venous (CVP), a prognostic marker AHF. Methods SNIP-AHF study was multicenter retrospective cohort of 200 consecutive patients hospitalized for AHF treated with sodium nitroprusside. Only...
Cardiogenic shock (CS) portends a dismal prognosis if hypoperfusion triggers uncontrolled inflammatory and metabolic derangements. We sought to investigate metabolomic profiles temporal changes in IL6, Ang-2, markers of glycocalyx perturbation from admission discharge eighteen patients with heart failure complicated by CS (HF-CS). Biological samples were collected 18 consecutive HF-CS at (T0), 48 h after (T1), (T2). ELISA analytical techniques targeted metabolomics performed Seven (44%) died...
Abstract Background Cardiogenic shock (CS) is an ominous condition with a high mortality rate. The diagnosis of CS relies upon signs and/or symptoms end-organ hypoperfusion. However, the combination hypoperfusion and systemic congestion poses serious risk significantly increases rates in critically ill patients. Purpose This study evaluated organ perfusion pressure (OPP), calculated as mean arterial (MAP) minus central venous (CVP), predictor outcomes CS. Methods All consecutive patients...
The novel coronavirus disease (COVID-19) has hit the healthcare system worldwide. risk of severe infection and mortality increases with advancing age, especially in subjects comorbidities such as cardiovascular disease, hypertension, diabetes, obesity cancer. Moreover, complications myocardial injury, heart failure thromboembolism are frequently observed COVID-19 cases, several biomarkers (troponin, NTproBNP D-Dimer) have been identified prognostic indicators severity worst outcome....
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Fondazione di Comunità Milano. Background Patients admitted to Cardiac Intensive Care Units (CICUs) have increasingly complex medical conditions; consequently, palliative care (PC) should be an integral component their management. Although there are robust experiences emanating from other intensive settings, has been less discussion about the role PC in CICUs and delivery end-of-life (EOL) this context is...
Abstract Introduction Timely reperfusion with primary percutaneous coronary intervention (pPCI) in patients ST–elevation myocardial infarction (STEMI) must be the standard of care, irrespective gender. Current guidelines mandate a door–to–balloon time less than 90 minutes from STEMI diagnosis to wire crossing. However, artery disease is characterized by relevant gender differences terms anatomy, pathophysiology, and clinical presentation. Female’s symptoms could deceitful, delayed. Aim our...