A5023449907- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Computational Drug Discovery Methods
Bioinformatics Institute
2021
Agency for Science, Technology and Research
2021
Genome Institute of Singapore
2021
University of Tartu
2021
Duke-NUS Medical School
2021
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and RNA-RNA interactions of wildtype (WT) mutant (Δ382) in cells using Illumina Nanopore platforms. We identify twelve potentially functional structural elements within genome, observe that subgenomic RNAs can form different structures, WT Δ382 virus genomes fold differently. Proximity ligation sequencing hundreds genome between host RNAs. binds strongly mitochondrial small nucleolar extensively...
Abstract SARS-CoV-2 has emerged as a major threat to global public health, resulting in societal and economic disruptions. Here, we investigate the intramolecular intermolecular RNA interactions of wildtype (WT) mutant (Δ382) virus cells using high throughput structure probing on Illumina Nanopore platforms. We identified twelve potentially functional structural elements within genome, observed that identical sequences can fold into divergent structures different subgenomic RNAs, WT Δ382...
Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation involved entities. These oncogenic modifications alter signal propagation which converge on gatekeeper kinases MEK1/2, transmitting input ERK1/2. Thus, targeted MEK inhibition causes qualitative alterations carcinogenic MAPK signals. Phosphorylation MEK1 loop positions S218 and S222 by RAF triggers conformational alignment MEK's catalytic pocket enable ATP-binding...
Abstract SARS-CoV-2 has emerged as a major threat to global public health, resulting in societal and economic disruptions. Here, we investigate the intramolecular intermolecular RNA interactions of wildtype (WT) mutant (Δ382) virus cells using high throughput structure probing on Illumina Nanopore platforms. We identified twelve potentially functional structural elements within genome, observed that identical sequences can fold into divergent structures different subgenomic RNAs, WT Δ382...