A5071550575- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Organic Chemistry Cycloaddition Reactions
- Synthesis of Indole Derivatives
- Photochromic and Fluorescence Chemistry
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Porphyrin and Phthalocyanine Chemistry
- Nerve injury and regeneration
- Vagus Nerve Stimulation Research
- Synthesis and Biological Evaluation
- Neuroscience and Neuropharmacology Research
University of Milan
2021-2025
Universidade Federal de São Paulo
2023
Institute for Bioengineering of Catalonia
2023
In the pressing quest of novel treatments for chronic pain, α7 nAChR silent agonists show efficacy as anti-inflammatory modulators and represent a promising strategy. Recent findings reveal that sulfonium ion can replace quaternary ammonium nitrogen an alternative pharmacophore activation. This study reports design, synthesis, electrophysiological evaluation new series sulfonium-based derivatives inspired by archetypal agonist NS6740. Our identify NSS-9 effectively alleviates inflammatory...
Several lines of evidence have indicated that nicotinic acetylcholine receptors (nAChR) contain α9 subunits, probably in combination with α10 may be valuable targets for the management pain associated inflammatory diseases through a cholinergic anti-inflammatory system (CAS), which has also been α7 nAChR. Both α7- and α9-containing neuronal nAChR can pharmacologically distinguished from high-affinity brain by their sensitivity to α-bungarotoxin, but other ways, they quite distinct...
Due to the microenvironment created by Schwann cell (SC) activity, peripheral nerve fibers are able regenerate. Inflammation is first response damage and removal of cellular myelin debris essential in preventing persistence local inflammation that may negatively affect regeneration. Acetylcholine (ACh) one neurotransmitters involved modulation through activity its receptors, belonging both muscarinic nicotinic classes. In this report, we evaluated expression α7 acetylcholine receptors...
In the last few years, fluorescence resonance energy transfer (FRET) receptor sensors have contributed to understanding of GPCR ligand binding and functional activation. FRET based on muscarinic acetylcholine receptors (mAChRs) been employed study dual-steric ligands, allowing for detection different kinetics distinguishing between partial, full, super agonism. Herein, we report synthesis two series bitopic 12-Cn 13-Cn, their pharmacological investigation at M1, M2, M4, M5 FRET-based...