A5101679501- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Receptor Mechanisms and Signaling
- Behavioral and Psychological Studies
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Photochromic and Fluorescence Chemistry
- Circular RNAs in diseases
- Photoreceptor and optogenetics research
- Bone Metabolism and Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Analog and Mixed-Signal Circuit Design
- Sleep and Wakefulness Research
- Systemic Sclerosis and Related Diseases
- Bone and Joint Diseases
- Neuroscience and Neuropharmacology Research
- Neuroscience, Education and Cognitive Function
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
Yonsei University
2013-2024
Institute for Bioengineering of Catalonia
2019-2023
Universidade Federal de São Paulo
2023
Dongguk University
2018
Ewha Womans University
2013-2015
Kyung Hee University
2011-2012
Stress has been shown to suppress immune function and increase susceptibility inflammatory disease psychiatric disease. CD4+CD25+ regulatory T (Treg) cells are prominent in regulation. This study was conducted determine if anti-CD25 antibody (Ab) mediated depletion of Treg mice stress-induced development depression-like behaviors, as well immunological neurochemical activity. To accomplish this, an elevated plus-maze test (EPM), tail suspension (TST), forced swim (FST) were used examine...
Significance This study addresses one of the most fundamental issues in sleep rhythm generation. The theory that low-threshold burst firing mediated by T-type calcium channels thalamocortical neurons is key component for spindles, has been accepted as dogma and appears throughout literature. In this study, however, vivo vitro evidence shows spindles are generated normally absence neurons. Furthermore, our data indicate a potentially important role tonic advances knowledge vigilance control...
Extracellular vesicles (EV) have been emerging as potential biomarkers for disease monitoring. In particular, tumor-derived EV (TDE) are known to carry oncogenic miRNA, so they can be used diagnosis of early cancer by analyzing the expression levels EV-miRNA circulating in blood. Here, using our novel microfluidic device, we rapidly and selectively isolate cancerous expressing breast cancer-derived surface markers CD49f EpCAM within 2 minutes. Based on seven candidates miRNA nominated from...
Flicker noise is the most crucial issue in an instrumentation amplifier (IA) for neural recordings because low-frequency signals overlap with frequency of amplifier's flicker noise. A Chopping technique, often used to reduce noise, not desirable high-impedance input sources due charge injection and clock feedthrough from MOSFETs chopper signal source, resulting a significant increase total input-referred Whereas have less at moment turning on, intrinsic can be then reduced by on off IA. This...
Myelination in corpus callosum plays important role for normal brain functions by transferring neurological information between various regions. However, the factors controlling expression of myelin genes myelination are poorly understood. Here, CXXC5, a recently identified protein with CXXC-type zinc finger DNA binding motif, was characterized as transcriptional activator major genes. We CXXC5 increased Wnt/β-catenin signaling. specifically expressed white matter induced through direct CXXC...
The physiological activity of proteins is often studied with loss-of-function genetic approaches, but the corresponding phenotypes develop slowly and can be confounding. Photopharmacology allows direct, fast, reversible control endogenous protein activity, spatiotemporal resolution set by illumination method. Here, we combine a photoswitchable allosteric modulator (alloswitch) 2-photon excitation using pulsed near-infrared lasers to reversibly silence metabotropic glutamate 5 (mGlu5)...
Abstract NF-κB is one of the key transcription factors activated by receptor activator ligand (RANKL) during osteoclast differentiation. The 8-kDa dynein L chain (LC8) was previously identified as a novel regulator. However, its physiological role an inhibitor remains elusive. In this study, we showed inhibitory LC8 in RANKL-induced osteoclastogenesis and signaling pathways protective osteolytic animal models. suppressed differentiation, actin ring formation, osteoclastic bone resorption....
Pancreatic ductal adenocarcinoma (PDAC) is considered one of the most aggressive malignancies and has high mortality poor survival rates. Therefore, there an urgent need to discover non-invasive biomarkers for early detection before PDAC reaches incurable stage. We hypothesized that liquid biopsy PDAC-derived extracellular vesicles (PDEs) containing abundant microRNAs (miRNAs) could be used diagnosis because they can selectively enriched are biologically stable. isolated PDEs by...
Exosomal microRNAs (miRNAs) are closely related to drug resistance in patients with breast cancer (BC); however, only a few roles of the exosomal miRNA‑target gene networks have been clinically implicated BC. Therefore, present study aimed identify differential expression miRNAs associated and their target mRNAs. <em>In</em> <em>vitro</em> microarray analysis was used verify differentially expressed (DEMs) drug‑resistant Next, tumor‑derived exosomes (TDEs) were isolated. Furthermore, it...
Autism spectrum disorder (ASD) is a neurodevelopmental marked by impaired social communication and repetitive, restricted behaviors activities. The prevalence of ASD has been increasing for the past 2 decades, but evidence-based therapeutic approaches are lacking patients with ASD. To date, there no cure core symptoms ASD, existing treatments focus on improving patient's function adaptation using behavioral intervention methods. Behavioral interventions have proven to show greatest effect...
Abstract The physiological activity of proteins is often studied with loss-of-function genetic approaches, but the corresponding phenotypes develop slowly and can be confounding. Photopharmacology allows direct, fast reversible control endogenous protein activity, spatiotemporal resolution set by illumination method. Here, we combine a photoswitchable allosteric modulator (alloswitch) two-photon excitation (2PE) using pulsed near-infrared lasers to reversibly silence mGlu 5 receptor in...
Abstract HER2-low is a new distinct type of breast cancer that characterized by low levels the HER2 protein. As treatment paradigms for are rapidly evolving with approval antibody-drug conjugates, identification more sensitive and reproducible assays needed. We aimed to investigate utility liquid biopsy in isolating tumor-derived extracellular vesicles (TDEs) diagnosis status. adopted an affinity-based approach isolate TDEs performed CNV analysis ERBB2/neu genes using tumor DNA present...
This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set experiments, metabolic changes occurring at multiple time points over 8 weeks response to CGH (35.33% wt/wt) were observed high-fat (HF, 60% energy as fat) diet-fed SD rats, hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels group significantly changed administration. part study, treatment...
The purpose of this study was to examine the validity and reliability Korean Comprehensive Scale for Assessment Challenging Behavior in Developmental Disorders (K-CSCB). In total, parents 189 patients with autism spectrum disorder (ASD) 168 controls completed K-CSCB, Problems Inventory (BPI) Child Checklist (CBCL). K-CSCB investigated. found be a reliable instrument (Cronbach's α=0.97). There significant difference between ASD control groups all subscale scores. Scores on subscales were...