A5003483422- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Pharmaceutical Practices and Patient Outcomes
- Pharmacy and Medical Practices
- Health Systems, Economic Evaluations, Quality of Life
- Aging and Gerontology Research
- Stroke Rehabilitation and Recovery
- Migration, Aging, and Tourism Studies
- Cholinesterase and Neurodegenerative Diseases
- Cerebrovascular and Carotid Artery Diseases
- Peptidase Inhibition and Analysis
- GDF15 and Related Biomarkers
- Advanced Glycation End Products research
- Assistive Technology in Communication and Mobility
- Retirement, Disability, and Employment
- Drug Transport and Resistance Mechanisms
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Urban and spatial planning
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Peripheral Artery Disease Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Prosthetics and Rehabilitation Robotics
- Hearing Loss and Rehabilitation
The University of Tokyo
2014-2024
Yokufukai Hospital
2018
Research Article8 January 2018Open Access Source DataTransparent process Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice Kiwami Kidana Laboratory Neuropathology and Neuroscience, Graduate School Pharmaceutical Sciences, The University Tokyo, Japan Department Geriatric Medicine, Internal Komeikai Hospital, Search for more papers by this author Takuya Tatebe Kaori Ito Venture Science Laboratories, R&D Division, Daiichi-Sankyo Co. Ltd.,...
The perceived age of older adults, as measured by their facial appearance, has been shown to be a robust biomarker aging predictive survival, telomere length and DNA methylation, reportedly correlates with carotid atherosclerosis bone status. This study aimed determine whether metrics dementia, including general cognition, vitality, depressive state self-supportability, have stronger correlations than chronological age.This included 124 patients who were admitted the Department Geriatric...
Alzheimer9s disease (AD) is characterized by the extensive deposition of amyloid-β peptide (Aβ) in brain. Brain Aβ level regulated a balance between production and clearance. The clearance rate decreased brains sporadic AD patients, indicating that dysregulation mechanisms affects pathologic process AD. Astrocytes are among most abundant cells brain implicated via their regulation blood–brain barrier, glymphatic system, proteolytic degradation. cellular morphology activity astrocytes...
Objectives This study aimed to evaluate the prescription patterns of drugs during last year life in homebound older adults who received home medical care. Methods We used a nationwide claims database Japan and selected aged ≥75 years care services from ≥12 months before their death. evaluated medications prescribed 12 death (month 12), 3 3) month 1). explored factors associated with decreased number cardiovascular preventive both 1. Results A total 118 661 participants were included,...
There is no consensus on how long antidementia medications should be administered to patients with Alzheimer disease (AD). To clarify this issue, we investigated the discontinuation of in Japanese home care settings, including community-dwelling and institutionalized patients. Using medical records from April 2017 March 2022 at 3 clinics Tokyo Chiba prefectures, selected AD who started receiving medicine. Forty-nine discontinued during observation period, there was apparent deterioration...
Older adults at the end-of-life stage receiving home visits from physicians often experience symptoms such as dyspnea, pain and fatigue, among others. This study aimed to investigate practices opinions of providing regarding palliative care for older with respiratory due non-malignant diseases in Japan.A nationwide questionnaire survey on non-cancer chronic was sent 2988 home-care 2020 through postal mail and/or email. The questions focused their background, use rating scales evaluate...
Alzheimer disease (AD) patients sometimes refuse to visit the doctor and have difficulty caring for themselves. To evaluate stress in caregivers associated with attending hospital, salivary amylase concentration was measured at home hospital. Outpatients diagnosed their spouse (>65 years old) were enrolled. Patients tested FAST (Functional Assessment Staging), MMSE, GDS15 (Geriatric Depression Scale 15), evaluated GDS 15 J-ZBI (Zarit Caregiver Burden Interview). We collected 1 ml of saliva...
Abstract Background The perceived age of older adults, as measured by their facial appearances, has been demonstrated to be a robust biomarker aging predictive survival, telomere length, and DNA methylation reportedly correlates with carotid atherosclerosis bone status. This study aims determine whether metrics dementia, including general cognition, vitality, depressive state, self‐supportability, have stronger correlations than chronological age. Method Study subjects were admitted the...
Abstract With demographic aging, many older adults require home medical care. Although home-based primary care is promoted in the United States and Japan, there insufficient evidence about it. We aimed to study characteristics prognoses of long-term patients. prospectively registered 151 patients, estimated receive physician visits for more than six months, a clinic Chiba, 2020. The mean (±SD) age was 83.9±10.0 years ranged from 31 102 years. Most patients were men (60.3%) aged 65 or above...
Alzheimer's disease (AD) is a most common neurodegenerative disorder among dementia caused by aberrant accumulation and deposition of amyloid β peptide (Aβ), which secreted from neuronal cells. Recently, pathophysiological roles astrocytes in AD brains have been highlighted, while it remains unclear how are involved the brain Aβ metabolism. We analyzed Aβ-degrading activity conditioned medium astrocytic found that media human astrocytoma-derived cell lines, U87 CCF-STTG1 cells, showed...
Abstract Older adults tend to need assistance for ambulation with the progression of aging or when suffering from diseases. With technological advances, servo-assistive robotic rollators are available besides canes and walkers assist disabled older adults. This study aimed investigate appropriate person conditions using a rollator its effects. Participants were 10 living in community (80.5±9.7 years; 4 males 6 females) who used (RT.2). After evaluating their physical (body composition,...
Abstract This study aimed to clarify the characteristics of older adults with dementia receiving physician home visits. We prospectively registered 179 patients aged ≥65 years, estimated receive visits for over 6 months, in a clinic Chiba, Japan, 2020–2021. The patients’ mean (±SD) age was 85.1±7.4 years and ranged from 68 102 years. Out total patients, 57.5% were men. collected clinical information; employed Dementia Assessment Sheet Community-based Integrated Care System 21 items (DASC-21)...