A5033484014- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- Plant Virus Research Studies
- Mycotoxins in Agriculture and Food
- Plant Pathogens and Fungal Diseases
- Antibiotic Resistance in Bacteria
- Salmonella and Campylobacter epidemiology
- Asthma and respiratory diseases
- Bacteriophages and microbial interactions
- Neonatal Respiratory Health Research
- Bacterial biofilms and quorum sensing
- Cystic Fibrosis Research Advances
Michigan State University
2014-2023
Michigan United
2022
To counteract infection with phage, bacteria have evolved a myriad of molecular defense systems. Some these systems initiate process called abortive infection, in which the infected cell kills itself to prevent phage propagation. However, such must be inhibited absence spurious death host. Here, we show that cyclic oligonucleotide based anti-phage signaling system (CBASS) accomplishes this by sensing intracellular folate molecules and only expressing group. These results enhance our...
Vibrio cholerae respires both aerobically and anaerobically and, while oxygen may be available to it during infection, other terminal electron acceptors are proposed for population expansion infection. Unlike gastrointestinal pathogens that stimulate significant inflammation leading elevated levels of or alternative acceptors, V . infections not understood induce a notable inflammatory response. To ascertain the respiration requirements we used Multiplex Genome Editing by Natural...
Vibrio cholerae replicates to high cell density in the human small intestine, leading diarrheal disease cholera. During infection, V. senses and responds environmental signals that govern cellular responses. Spatial localization of within intestine affects nutrient availability metabolic pathways required for replicative success. Metabolic processes used by reach such densities are not fully known. We sought better define traits contribute levels during infection. By disrupting pyruvate...
Abstract A major challenge faced by bacteria is infection bacteriophage (phage). Abortive one strategy for combating phage in which an infected cell kills itself to limit replication, thus protecting neighboring kin. One class of abortive systems the c yclic oligonucleotide b ased a nti-phage s ignaling ystem (CBASS) relies on two core enzymatic activities; oligo-nucleotide cyclase that activated following and cyclic-oligo-nucleotide sensitive effector whose activity cell. However,...
Abstract Vibrio cholerae is a bacterial pathogen that replicates to high cell density in the small intestine of human hosts leading diarrheal disease cholera. During infection, V. senses and responds environmental signals govern cellular responses. Spatial localization within affects nutrient availability therefore metabolic pathways required for replicative success pathogen. Metabolic processes used by reach such densities are not fully known. Here we seek better define traits contribute...
Abstract Vibrio cholerae respires both aerobically and anaerobically and, while oxygen may be available to it during infection, other terminal electron acceptors are proposed for population expansion infection. Unlike gastrointestinal pathogens that stimulate significant inflammation leading elevated levels of or alternative acceptors, V. infections not understood induce a notable inflammatory response. To ascertain the respiration requirements we used Multiplex Genome Editing by Natural...