A5101973462- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Prostate Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
Taizhou Central Hospital
2023-2025
Taizhou University
2023-2025
First Affiliated Hospital of Wannan Medical College
2024
Chronic inflammation, immune cell infiltration, and metabolic reprogramming play a crucial role in the development of head neck squamous carcinoma (HNSCC). Based on summary-level data from genome-wide association study (GWAS), this used Mendelian randomization (MR) analysis to investigate causal relationship between phenotype HNSCC. Two-step MR was employed quantify proportion effect metabolite-mediated immunophenotypes 16 phenotypes exhibited with HLA DR + CD4 AC (OR: 1.31, 95% CI...
Abnormal RNA N7-methylguanosine (m7G) modification is known to contribute effects on tumor occurrence and development. Nevertheless, the mechanisms of its function in immunoregulation, microenvironment (TME) modulation, promotion remain largely unknown. A series computer-aided bioinformatic analyses were conducted based transcriptomic, single-cell sequence, spatial transcriptomic data determine m7G patterns head neck squamous cell carcinoma (HNSCC). Consensus clustering approach was employed...
Gastric adenocarcinoma (GC), along with its tumor microenvironment (TME), poses great challenges for clinical treatment strategies. Single-cell sequencing has become an important tool analyzing TME heterogeneity, cell subpopulation, and gene expression patterns. 56 GC single-cell samples were analyzed, focusing on by delineating cancer cells, cancer-associated fibroblasts (CAFs), macrophages. The spatial transcriptome was used to clarify the distribution characteristics of each cellular...
<title>Abstract</title> <bold>Background</bold> The delineation of molecular mechanisms and identification prognostic markers between different subtypes stages prostate cancer is vital for the enhancement therapeutic approaches against this disease. We aimed to identify novel immune-related biomarkers that could be instrumental in assessing prognosticating across its stages.<bold>Methods</bold> Transcriptomic clinical data were obtained from TCGA GEO databases differentially expressed genes...
Understanding the molecular mechanisms and identifying prognostic markers across various subtypes stages of prostate cancer (PCa) are crucial for improving therapeutic strategies against disease. This study focuses on discovering novel immune-related biomarkers that could aid in evaluation prognosis PCa at different serve as promising targets.