A5073936416- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Neurogenesis and neuroplasticity mechanisms
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Cancer-related gene regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Retinal Development and Disorders
- Inflammasome and immune disorders
- Enzyme Structure and Function
- Hippo pathway signaling and YAP/TAZ
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and genetic disorders
- Nerve injury and regeneration
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
Huizhou Central People's Hospital
2023-2025
Guangdong Medical College
2023-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
Tongji University
2017-2025
Benedictine University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
West China Medical Center of Sichuan University
2024
Peking Union Medical College Hospital
2022-2024
Xi'an Jiaotong University
2024
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast...
Abstract Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation epithelial cells into mesenchymal with molecular alterations can occur during epithelial–mesenchymal transition (EMT). EMT mechanism accelerates cancer metastasis and drug resistance ability in human cancers. Among different regulators EMT, Wnt/β-catenin axis has been emerged as a versatile modulator. Wnt is active form physiological condition due to function GSK-3β that destructs β-catenin,...
Despite the challenges posed by drug resistance and side effects, chemotherapy remains a pivotal strategy in cancer treatment. A key issue this context is macroautophagy (commonly known as autophagy), dysregulated cell death mechanism often observed during chemotherapy. Autophagy plays cytoprotective role maintaining cellular homeostasis recycling organelles, emerging evidence points to its significant promoting progression. Cisplatin, DNA-intercalating agent for inducing cycle arrest,...
Accumulated evidence highlights the significance of crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) N6-methyladenosine (m6A). Herein, we conducted a widespread analysis regarding 5mC m6A regulators in hepatocellular carcinoma (HCC).Pan-cancer genomic was presented at transcriptomic, genomic, epigenetic, other multi-omics levels. Hub were summarized to define an module eigengene (EME), which reflected both pre- post-transcriptional...
Type 2 diabetes mellitus (T2DM) affects the formation of carotid atherosclerotic plaques (CAPs) and patients are prone to plaque instability. It is crucial clarify transcriptomics profiles identify biomarkers related progression T2DM complicated by CAPs. Ten human CAP samples were obtained, whole transcriptome sequencing (RNA-seq) was performed. Samples divided into two groups: (DM) versus non-DM groups unstable stable groups. The Limma package in R used lncRNAs, circRNAs, mRNAs. Gene...
The striatum is a central regulator of behavior and motor function through the actions D1 D2 medium-sized spiny neurons (MSNs), which arise from common lateral ganglionic eminence (LGE) progenitor. molecular mechanisms cell fate specification these two neuronal subtypes are incompletely understood. Here, we found that deletion murine Meis2, highly expressed in LGE derivatives, led to large reduction striatal MSNs due block their differentiation. Meis2 directly binds Zfp503 Six3 promoters...
Cell pyroptosis, a Gasdermin-dependent programmed cell death characterized by inflammasome, plays complex and dynamic role in Gastric cancer (GC), serious threat to human health. Therefore, the value of pyroptosis-related genes (PRGs) as prognostic biomarkers therapeutic indicators for patients needs be exploited GC. This study integrates single-cell RNA sequencing (scRNA-seq) dataset GSE183904 with GC transcriptome data from TCGA database, focusing on expression distribution PRGs at level....
The generation and differentiation of cortical projection neurons are extensively regulated by interactive programs transcriptional factors. Here, we report the cooperative functions transcription factors Bcl11a Bcl11b in regulating development neurons. Among cells derived from neural stem cells, is expressed progenitors neurons, while expression restricted to Using conditional knockout mice, show that deficiency leads reduced proliferation precocious progenitor which exacerbated when...
Purpose: The “high-risk phenotype” of corneal graft recipients is considered to be related preexisting vascularization such as that associated with herpes simplex virus-1 (HSV-1) keratitis (HSK). purpose this study was investigate the immunologic mechanisms underlying accelerated rejection using a mouse model HSK. Methods: Herpes virus type 1 induced in BALB/c mice. Syngeneic and allogeneic (C57BL/6 mice) grafts were performed mice HSK at different times after infection. Some on HSV-infected...
Curcumin is the most abundant derivative of turmeric rhizome. Although studies have proved that curcumin could inhibit growth tumors, its specific molecular mechanism has not yet been fully elucidated. This study aims to systematically elaborate mechanisms against hepatocellular carcinoma. The anti-tumor effect was determined by cell viability test. Flow cytometry applied examine cycle and apoptosis cancer cells, migration detected wound healing experiments. expressions signal transducers...
Chemotherapy is one of the primary treatments for both small cell lung cancer (SCLC) and non-small (NSCLC), however, chemoresistance develops over time a bottleneck to effective chemotherapy worldwide. Therefore, development new potent therapeutic agents overcome utmost importance. Triptolide natural component extracted from Tripterygium Wilfordii, Chinese plant; our study aimed evaluate its anti-tumor effects in taxol-resistant human adenocarcinoma investigate molecular mechanisms...
Urolithin A (UA) is a microbial metabolite of natural polyphenols ellagitannins and ellagic acid with well-established antitumor properties against various malignancies. However, the exact role UA in gastric cancer (GC) progression remains largely unclear. In present study, we investigated effects potential mechanisms GC vitro vivo. Our results revealed that could suppress cell proliferation, inhibit migration invasion, promote apoptosis, induce autophagy via...
Background: Gastric cancer (GC) is a malignant tumor with high prevalence and fatality. Cuproptosis recently identified copper-dependent programmed cell death mechanism. Multiple studies have demonstrated the profound impact of immune microenvironment on development. Hence, we decided to excavate potential functional roles cuproptosis-related genes (CRIGs) in GC their values as biomarkers. Methods: Cuproptosis- immune-related were curated from top published cuproptosis cellular immunity....
Immune checkpoint inhibitors (ICIs) have revolutionized colon cancer treatment, but their efficacy is largely restricted by the limited presence of CD8+ cytotoxic T lymphocytes (CTLs). However, specific genetic alterations that impact CTL infiltration in remain poorly understood. Here, we analyzed clinical and multi-omics data from Memorial Sloan-Kettering Cancer Center (MSKCC) ICIs-treated The Genome Atlas (TCGA) adenocarcinoma (COAD) cohorts to screen key mutations may influence...