A5062206970- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Aortic aneurysm repair treatments
- Orthopedic Infections and Treatments
- Genetic factors in colorectal cancer
- Bacterial Identification and Susceptibility Testing
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Cancer Genomics and Diagnostics
- Orthopaedic implants and arthroplasty
- Extracellular vesicles in disease
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neutropenia and Cancer Infections
- Gastroesophageal reflux and treatments
- Colorectal and Anal Carcinomas
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmacological Receptor Mechanisms and Effects
- Chromatin Remodeling and Cancer
- Antibiotics Pharmacokinetics and Efficacy
- Methemoglobinemia and Tumor Lysis Syndrome
- Brain Metastases and Treatment
University of Washington
2024-2025
Fred Hutch Cancer Center
2024-2025
UPMC Hillman Cancer Center
2021-2024
University of Pittsburgh Medical Center
2023
Mayo Clinic
2019
Einstein Medical Center Philadelphia
2017-2019
National Taiwan University Hospital
2019
Mayo Clinic in Arizona
2017
National Taiwan University
2016
TPS313 Background: Currently, pembrolizumab is one of the front-line therapies for patients with MSI-H CRC. However, approximately 40% who received experienced disease progression early in course (KEYNOTE 177). Therefore, there still an unmet need to enhance efficacy checkpoint inhibitors CRC has a higher level expression VEGF blood compared its MSS counterpart (Hansen et al. Colorectal Dis. 2011). Consistently, exploratory analysis CALBG-80405 and PARADIGM trial showed that were more likely...
Compared with the traditional ways of gaining health-related information from newspapers, magazines, radio, and television, Internet is inexpensive, accessible, conveys diverse opinions. Several studies on how increasing use affected outpatient clinic visits were inconclusive.The objective this study was to examine role ambulatory care-seeking behaviors as indicated by number after adjusting for confounding variables.We conducted using a sample randomly selected general population in Taiwan....
557 Background: Alterations in ARID1A, PBRM1 and BAP1 subunits of the SWI/SNF complex are common biliary tract cancers (BTCs) have been implicated tumor microenvironment (TME) immunomodulation. However, there is heterogeneity outcomes, with conferring improved survival vs worse ARID1A. We explored relationships between alterations putative immunotherapy biomarkers genomic co-alterations. Methods: examined BTC patients Tempus database alterations. Co-alterations were identified through...
ABSTRACT Introduction We retrospectively studied young patients with head and neck squamous cell carcinoma (HNSCC) to identify factors associated disease‐specific survival (DSS). Methods Patient tumor characteristics of aged ≤45 who received treatments for non‐metastatic HNSCC were collected DSS. Proportional hazards regression was applied separately surgical non‐surgical patients. Results 230 included. Surgical had similar Higher pathologic stages, positive margins, perineural invasion...
There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles sociodemographic factors and upfront stem cell transplantation (SCT).The National Cancer Data Base is a US cancer database approximately 34 million from >1500 centers. Patients MM were identified using International Classification Diseases for Oncology (ICD-O) code 9732 January 2004...
Abstract Background We retrospectively evaluated radiomics as a predictor of the tumor microenvironment (TME) and efficacy with anti‐PD‐1 mAb (IO) in R/M HNSCC. Methods Radiomic feature extraction was performed on pre‐treatment CT scans segmented using 3D slicer v4.10.2 key features were selected LASSO regularization method to build classification models XGBoost algorithm by incorporating cross‐validation techniques calculate accuracy, sensitivity, specificity. Outcome measures disease...
A 55-year-old Caucasian woman with history of multiple sclerosis and neurogenic bladder suprapubic catheter presented to the emergency department pain lethargy for 2 weeks. She was hypoxic, saturating 88% on room air. Her examination notable subtle bluish
e13078 Background: Bloodstream infection (BSI) is a leading cause of in-hospital mortality for cancer patients. Our goal to describe the temporal trend microbiological profiles and inpatient outcomes through large national database. Methods: National Inpatient Sample largest U.S. database hospitalized patients including 20% from 4,378 hospitals. Hospitalizations with BSI were identified by ICD-9 codes bacteremia fungemia 2006-2014. 21 common microorganisms ICD-9-CM as BSI. We assessed...
6042 Background: The development of biomarkers that reliably predict response to anti-PD-1 mAb therapy (IO) is a critical need. Small (30-150 nm) extracellular vesicles (sEV), aka exosomes, are “molecular mimics” their parent cells. In cancer, plasma sEV mixtures tumor-derived exosomes (TEX) and produced by non-malignant We conducted retrospective study R/M HNSCC patients treated with IO evaluate as predictive biomarkers. Methods: evaluated in (n = 24) obtained just prior initiation IO....
e18054 Background: HNSCC is increasingly being diagnosed in a younger population, with variable prognosis. While studies have evaluated outcomes young compared to older patients, evaluation of prognostic factors specifically that may help guide treatment decisions, needed. Therefore, we conducted retrospective study investigate the association patient and tumor characteristics disease specific survival (DSS) patients ≤45 years old (yo). Methods: Patients treated at University Pittsburgh...