A5029455748- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advances in Oncology and Radiotherapy
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Computational Drug Discovery Methods
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Social Media in Health Education
- Synthesis and biological activity
- Innovations in Medical Education
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Response and Inflammation
- Economic and Financial Impacts of Cancer
- Advanced Radiotherapy Techniques
- Coenzyme Q10 studies and effects
- 14-3-3 protein interactions
Illinois College
2024-2025
University of Illinois Urbana-Champaign
2024-2025
Bahçeşehir University
2018-2022
Ubiquitin-Specific Protease 7 (USP7) has emerged as a critical therapeutic target in cancer due to its regulatory roles of tumor suppressors, oncoproteins, and epigenetic modifiers. In this study, we present comprehensive drug repurposing strategy identify potential USP7 inhibitors from curated library 6,654 FDA-approved investigational small molecules. Using structure-based pharmacophore models derived USP7-inhibitor crystal structures, conducted virtual screening select candidates with...
The ubiquitin-specific protease 7 (USP7) is a highly promising well-validated target for variety of malignancies. USP7 critical in regulating the tumor suppressor p53 along with numerous epigenetic modifiers and transcription factors. Previous studies showed that inhibitors led to increased levels anti-proliferative effects hematological solid cell lines. Thus, this study aimed identify potent safe hit as potential anti-cancer therapeutics via an integrated computational approach combines...
Oncology education at medical schools is often fragmented, under-represented, and nonstandardized. Medical students lack essential knowledge, skills, attitudes necessary for them to provide optimal primary care patients with cancer upon graduation.In this study, we designed assessed the impact of a compact oncology teaching conference on students. The covered topics in biology, public health, diagnosis, patient management, treatment, communication skills. completed voluntary presurveys...
e14611 Background: Expression of programmed cell death ligand 1 (PD-L1) in non-small lung cancer (NSCLC) has often been measured by the Tumor Proportion Score (TPS) (1). Recently, Combined Positive (CPS), which evaluates PD-L1 expression tumor and inflammatory cells applies to other types including gastric head neck cancers, was found be equally predictive response immunotherapy NSCLC In this study, we aimed conduct a single center retrospective analysis evaluate clinical use impact using...
Adult gliomas vary significantly in terms of their genetics, epigenetics, phenotypes as well clinical outcomes1. Optimal tumor classification that leads to more precise diagnoses, and which influences therapy selection is hence critically important. Targeted next-generation sequencing (NGS) a highly reliable efficient novel tool for the identification biomarkers diagnosis CNS tumors2. In this study, we aimed determine implications integrating NGS findings with traditional diagnostic data on...
e14011 Background: It is known that gliomas represent a wide variety of entities with varying biological features and clinical outcomes (Neuropathol Exp Neurol 2019, 78). Hence, optimal tumor classification aids in the diagnosis management patients which supports use specific treatment modalities critical importance neuro-oncology. Targeted next-generation sequencing (NGS) has proven to be an efficient reliable tool for identifying prognostic biomarkers CNS tumors (Neurooncol Adv 2020, 2)....
11024 Background: Undergraduate medical education in oncology is often fragmented and non-standardized among schools (BMC Med Educ 17:100, 2017). Oncology initiatives are thus critically needed to increase cancer awareness improve students’ understanding of the principles multidisciplinary approach oncology. We designed implemented an online program with aim providing students early exposure field Our was adapted from Australian Ideal Curriculum for Medical Schools included six sessions...
Abstract The deubiquitinating enzyme ubiquitin-specific protease 7 (USP7) is a novel protein target for various hematological and solid-organ malignancies [1]. Its inhibition thus considered highly promising strategy the development of new antineoplastic drugs. In this study, we applied an integrated approach with major focus on pharmacophore modeling screening combined molecular dynamic simulations free energy-based calculations to identify drugs as USP7-small molecule inhibitors. We...