A5056102755- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Retinal and Optic Conditions
- Vestibular and auditory disorders
- RNA and protein synthesis mechanisms
- Connexins and lens biology
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- RNA regulation and disease
- Cerebral Venous Sinus Thrombosis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Retinal and Macular Surgery
- Drug-Induced Ocular Toxicity
- Biochemical Analysis and Sensing Techniques
- Ophthalmology and Visual Health Research
- Ear Surgery and Otitis Media
- Corneal surgery and disorders
- Congenital heart defects research
- Photodynamic Therapy Research Studies
- Acute Ischemic Stroke Management
- Renal and Vascular Pathologies
- Retinoids in leukemia and cellular processes
- Meningioma and schwannoma management
University College London
2009-2023
Moorfields Eye Hospital
2009-2023
Moorfields Eye Hospital NHS Foundation Trust
2011-2021
NIHR Moorfields Biomedical Research Centre
2015
Institute of Ophthalmology
2008
UCL Australia
2006
St James's University Hospital
2003
<h3>Background</h3> Usher syndrome (USH) is an autosomal recessive disorder comprising retinitis pigmentosa, hearing loss and, in some cases, vestibular dysfunction. It clinically and genetically heterogeneous with three distinctive clinical types (I–III) nine genes identified. This study a comprehensive genetic analysis of 172 patients evaluates the contribution digenic inheritance. <h3>Methods</h3> The <i>MYO7A, USH1C, CDH23, PCDH15, USH1G, USH2A, GPR98, WHRN, CLRN1</i> candidate gene...
Defects in USH2A cause both isolated retinal disease and Usher syndrome (ie, deafness). To gain insights into isolated/nonsyndromic retinopathy, we screened 186 probands with recessive no hearing complaint childhood (discovery cohort) 84 (replication cohort). Detailed phenotyping, including imaging audiological assessment, was performed individuals two likely disease-causing variants. Further genetic testing, screening for a deep-intronic variant large deletions/duplications, those one...
<b>Background:</b> Usher syndrome, a combination of retinitis pigmentosa (RP) and sensorineural hearing loss with or without vestibular dysfunction, displays high degree clinical genetic heterogeneity. Three subtypes can be distinguished, based on the age onset severity impairment, presence absence abnormalities. Thus far, eight genes have been implicated in together comprising 347 protein-coding exons. <b>Methods:</b> To improve DNA diagnostics for patients we developed genotyping...
In clinical practice, intravitreal anti-vascular endothelial growth factor (anti-VEGF) injection intervals for patients with neovascular age-related macular degeneration (nAMD) are based on disease activity, active or recurrent requiring more frequent injections. Injection interval modification criteria differ from those used in trials, thereby potentially affecting treatment outcomes. This analysis evaluated the potential impact of applying activity recent trials (TENAYA/LUCERNE;...
Purpose: To assess correlation for anterior chamber flare grading between clinicians with different levels of experience and semi-automated reading in a cohort patients heterogeneous uveitic entities.Methods: Fifty-nine observations from 36 were recorded analyzed statistical association. In each patient, was assessed objectively using the Kowa FM-700 laser photometer, subjective masked by two performed.Results: The study demonstrated disparity readings clinical graders one step disagreement...
To assess the significance and evolution of parafoveal rings high-density fundus autofluorescence (AF) in 12 patients with retinitis pigmentosa (RP).Twelve autosomal recessive RP or Usher syndrome type 2 were ascertained who had a ring AF visual acuity 20/30 better at baseline. Photopic scotopic fine matrix mapping (FMM) performed to test sensitivity across macula. imaging FMM repeated after 4 8 years optical coherence tomography (OCT) performed.The size reduced over time disappeared one...
<h3>Background/aims</h3> To evaluate the clinical efficacy and safety of combined repeated Ozurdex macular laser therapy (MLT) compared with MLT monotherapy in participants visual impairment due to centre-involving diabetic oedema (DMO). <h3>Methods</h3> 80 patients best corrected acuity (BCVA) between 54 78 ETDRS letters DMO were randomised combination or only. The arm received mandated injections at baseline 16 weeks followed by retreatment criteria-guided pro-re-nata 32 48 weeks. Patients...
In Brief Purpose: To determine the molecular cause of sector retinitis pigmentosa and hearing loss in two affected siblings. Methods: Direct DNA sequencing USH1C gene was performed Putative pathogenic sequence changes were assayed their parent's chromosomes control chromosomes. Clinical examination included visual acuity measurement, field electrophysiologic assessment, fine matrix mapping. Retinal imaging with fundus photography, scanning laser ophthalmoscope (fundus autofluorescence),...
To propose a classification system to grade semi-automated flare readings and assess its correlation with clinical grading also explore the utility of an additional step in assessment between grades 0 1.Semi-automated from 103 eyes uveitis were taken using Kowa FM 700 laser meter classified into two models (LFCM LFCM_1), introduction 0.5 was explored.Good present conventional SUN proposed for (weighted kappa (WK) = 89.64%, p < 0.001). Semi-automated LFCM_1) had WK agreement 82.52% 79.85% (p...
Aim: To report a case of optic neuropathy secondary to Linezolid, second line anti tuberculosis agent.Case Report: 22 year Indian male with multidrug resistant spinal and TB meningitis was started on drugs. Within one month onset drug, he noted have in both eyes. Visual field electro diagnostics suggested neuropathy.Discussion: Linezolid is synthetic oxazolidinone broad spectrum antibiotic has been off label use for (MDR-TB). There are very scattered reports this drug. In our case, the...
Stellate nonhereditary idiopathic foveomacular retinoschisis is a disorder characterized by splitting of the retina at macula, without known underlying mechanical or inherited cause. This study investigates demographic, anatomical, and functional characteristics subjects with stellate retinoschisis, to explore potential mechanisms.In this single-site, retrospective, cross-sectional, observational study, data were collected from 28 eyes 24 retinoschisis. Descriptive statistics reported, based...