A5103050101- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Fibroblast Growth Factor Research
- Cancer and Skin Lesions
- Hedgehog Signaling Pathway Studies
University of Freiburg
2023-2025
German Cancer Research Center
2025
Heidelberg University
2025
University Medical Center Freiburg
2024
University Hospital Münster
2021-2022
Abstract Breast cancer continues to be a serious public health problem. The role of the hedgehog pathway in normal development mammary gland as well carcinogenesis and progression breast is subject intense investigation, revealing functional interactions with cell surface heparan sulfate. Nevertheless, its influence on prognosis, relation specific sulfation motifs sulfate have only been poorly studied large patient cohorts. Using database KMplotter that includes gene expression survival data...
Systemic juvenile idiopathic arthritis (JIA) features characteristics of autoinflammation and autoimmunity, culminating in chronic arthritis. In this study, we hypothesized that aberrant or incomplete polarization T helper cells contributes to disease pathology.Cells serum samples were obtained from healthy controls (n = 72) systemic JIA patients 171). Isolated naive cultured under Th1, Th17, follicular (Tfh) peripheral (Tph)-polarizing conditions partly cocultured with allogenic memory B...
Central nervous system lymphomas (CNSL) display remarkable clinical heterogeneity, yet accurate prediction of outcomes remains challenging. The IPCG criteria are widely used in routine practice for the assessment treatment response. However, value ultimate outcome is largely unclear, mainly due to uncertainty delineating complete from partial responses during and after treatment.
<title>Abstract</title> Various clinical scenarios preclude or delay invasive stereotactic biopsies and subsequent histopathological assessment for the diagnosis of central nervous system lymphoma (CNSL), necessitating innovative minimal-invasive strategies. We designed a digital droplet PCR (ddPCR) assay identification CNSL in practice by detecting <italic>MYD88</italic> L265P mutations circulating tumor DNA (ctDNA) cerebrospinal fluid (CSF). After approval national accreditation authority,...
Objective Systemic juvenile idiopathic arthritis (sJIA) features characteristics of autoinflammation and autoimmunity, culminating in chronic arthritis. Previous work indicated decreased IFNγ-expression by T helper (Th) cells sJIA. Here, we hypothesized this to result from aberrant or incomplete Th cell polarization. Methods Cells sera were obtained healthy controls (HC, n=26) sJIA patients (n=61). Isolated naïve cultured under Th1, Th17, follicular peripheral (Tf/ph) polarizing conditions...