A5069647049- Pharmaceutical Practices and Patient Outcomes
- Nursing Roles and Practices
- Primary Care and Health Outcomes
- Drug Transport and Resistance Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Patient Safety and Medication Errors
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Healthcare cost, quality, practices
- Fatty Acid Research and Health
- Antimicrobial Resistance in Staphylococcus
- Innovations in Medical Education
- Kruppel-like factors research
- Diabetes Treatment and Management
- Epilepsy research and treatment
- Health Sciences Research and Education
- Pharmacy and Medical Practices
- Pharmacological Effects and Toxicity Studies
- Cancer, Lipids, and Metabolism
- Global Health Workforce Issues
- TGF-β signaling in diseases
- Pharmacogenetics and Drug Metabolism
- Eicosanoids and Hypertension Pharmacology
- Metabolism, Diabetes, and Cancer
- Emergency and Acute Care Studies
Alfred Health
2017-2019
The Alfred Hospital
2018
Society of Hospital Pharmacists of Australia
2017
RMIT University
2013-2014
Pharmaceutical interventions for diabetes aim to control glycaemia and prevent the development of complications, such as cardiovascular diseases. Some anti-hyperglycaemic drugs have been found adverse effects in their own right, limiting therapeutic role. Glucokinase activity pancreas is critical enhancing insulin release response hyperglycaemia. activators (GKAs) are novel agents which act by formation glucose-6-phosphate leading increased production subsequent suppression blood glucose....
Abstract Objectives (S)-[6]-Gingerol is under investigation for a variety of therapeutic uses. Transforming growth factor (TGF)-β stimulates proteoglycan synthesis, leading to increased binding low-density lipoproteins, which the initiating step in atherosclerosis. We evaluated effects (S)-[6]-gingerol on these TGF-β-mediated changes explore its potential as an anti-atherosclerotic agent. Methods Purified was assessed synthesis by [35S]-sulfate incorporation into glycosaminoglycan chains and...
Abstract Objectives Suramin is a polysulfonated naphthylurea with antiparasitic and potential antineoplastic activity. Suramin's pharmacological actions, which have not yet been fully elucidated, include antagonism of the action platelet-derived growth factor (PDGF) at its receptor. We investigated effects suramin on PDGF-stimulated proteoglycan synthesis. Methods Human vascular smooth muscle cells (VSMCs) were incubated in presence absence PDGF [3H]thymidine or 35SO4 as radiolabels....
Abstract Extended scope of practice roles for pharmacists are relatively new in the Australian hospital setting; however they increasing uptake. Therapeutic drug monitoring ( TDM ) represents a critical area involvement pharmacists. The Alfred Health Pharmacy Department introduced pharmacist‐led program 2012 vancomycin and aminoglycoside antibiotics. Following development an in‐house credentialing program, nearly 160 have been successfully credentialed through initial 95 annual...
Aims Patients with Alzheimer's disease (AD), the most common form of dementia, have reduced P‐glycoprotein (P‐gp) function at blood–brain barrier. However, effect AD on P‐gp in peripheral organs, and impact medication efficacy toxicity is unknown. In this study, clinical chart review physiologically based pharmacokinetic (PBPK) modelling were employed to determine whether disease‐associated changes could be assessed from clinically measured digoxin concentrations patients without dementia....
Sodium fusidate (fusidic acid) is an antimicrobial agent that used in the treatment of staphylococcal and streptococcal infections. Several case reports have noted a drug interaction between sodium CYP3A4 metabolised statins, leading to statin toxicity. It unclear whether has potential cause interactions with other cytochrome P450 enzymes.To investigate effects on recombinant enzymes (1A2, 2C9, 2C19, 2D6 3A4) in-vitro.A range concentrations (0.1µM, 1µM, 10µM, 100µM, 300µM, 1000µM 10000µM)...
The second edition of this book features a revised format from larger range contributing authors with multidisciplinary background. It is pocket-sized small font. set out in alphabetical monographs which aim to provide ready information the pharmacists conducting medication reviews at bedside or ambulatory settings. There are different types including selection disease states, drugs, electrolytes, and clinical assessment tools.
The expression and function of P-glycoprotein (P-gp), an efflux transporter at the blood-brain barrier (BBB) is altered in patients with Alzheimer's disease (AD). However, P-gp expressed numerous other tissues, including small intestine liver, plays a key role disposition many medications. Altered organs responsible for drugs that are substrates (i.e., digoxin) may cause changes concentrations, impact drug efficacy and/or toxicity AD. A retrospective chart review was conducted Alfred...