Alexander Crane
A5023666118- FOXO transcription factor regulation
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Circular RNAs in diseases
- Cardiac Valve Diseases and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Bioinformatics and Genomic Networks
- Reproductive System and Pregnancy
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
Dana-Farber Cancer Institute
2021-2025
Broad Institute
2022-2025
Boston University
2024
German Cancer Research Center
2023
Hopp Children's Cancer Center Heidelberg
2023
Heidelberg University
2023
Sabin Vaccine Institute
2023
University of Cincinnati
2023
Harvard University
2022
University of Pennsylvania
2021
Abstract Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with recurrent mutations in histone H3.3. These promote oncogenesis by dysregulating gene expression through alterations of modifications. We identify aberrant DNA repair as an independent mechanism, which fosters genome instability H3.3 mutant pHGG, opens new therapeutic options. The two most frequent K27M G34R, drive replication-associated damage non-homologous end joining (NHEJ). Aberrant NHEJ is...
MotivationWhile structural variants (SVs) harbor rich insight into the pathogenicity of diseases such as cancer, models used to study these SVs often lack matched normal samples. This makes it difficult separate germline from cancer-related variants. Our ability confidently associate disease phenotypes with their underlying genomic events depends on differentiating cancer SVs. Given that and somatic are generated by different processes, we hypothesized they will be distinguishable based...
Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models human transplant registry data to reveal that induced exhausted CD8 T cells (Preg-TEX), which associated with prolonged allograft survival. Maternal shared features of exhaustion from cancer chronic infection, including transcriptional down-regulation ribosomal proteins up-regulation TOX inhibitory receptors. Similar other...
Abstract Forkhead box R2 (FOXR2) is a forkhead transcription factor located on the X chromosome whose expression normally restricted to testis. In this study, we performed pan-cancer analysis of FOXR2 activation across more than 10,000 adult and pediatric cancer samples found be aberrantly upregulated in 70% all types 8% individual tumors. The majority tumors (78%) expressed through previously undescribed epigenetic mechanism that involves hypomethylation novel promoter, which was...
Abstract Although several recent studies have characterized structural variants (SVs) in germline and cancer genomes, the features of SVs these different contexts not been directly compared. We examined similarities differences between 2 million 115 thousand tumor from a cohort 963 patients The Cancer Genome Atlas (TCGA). found significant related to their genomic sequences localization that suggest SV-generating processes selective pressures. For example, we transposon-mediated shape much...
Abstract Pediatric high-grade gliomas (pHGGs), encompassing hemispheric and diffuse midline (DMGs), remain a devastating disease. The last decade has revealed oncogenic drivers including single nucleotide variants (SNVs) in histones. However, the contribution of structural (SVs) to gliomagenesis not been systematically explored due limitations early SV analysis approaches. Using algorithms, we recently created, analyzed SVs whole-genome sequences 179 pHGGs novel cohort treatment naïve...
Summary Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with recurrent mutations in histone H3.3. These promote oncogenesis by dysregulating gene expression through alterations of modifications. We identify aberrant DNA repair as an independent oncogenic mechanism, which fosters genome instability tumor cell growth H3.3 mutant pHGG, thus opening new therapeutic options. The two most frequent K27M G34R, drive replication-associated damage non-homologous end...
<div>Abstract<p><i>Forkhead box R2</i> (<i>FOXR2</i>) is a forkhead transcription factor located on the X chromosome whose expression normally restricted to testis. In this study, we performed pan-cancer analysis of <i>FOXR2</i> activation across more than 10,000 adult and pediatric cancer samples found be aberrantly upregulated in 70% all types 8% individual tumors. The majority tumors (78%) expressed FOXR2 through previously undescribed...
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits
Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits