A5074717613- Glaucoma and retinal disorders
- Mitochondrial Function and Pathology
- Traditional Chinese Medicine Analysis
- Connexins and lens biology
- interferon and immune responses
- Immune Response and Inflammation
- Retinal Development and Disorders
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
Xiangya Hospital Central South University
2023-2025
Central South University
2023-2025
Glaucoma is a common neurodegenerative disease characterized by progressive retinal ganglion cell (RGC) loss and visual field defects. Pathologically high intraocular pressure (ph-IOP) an important risk factor for glaucoma, it triggers molecularly distinct cascades that control RGC death axonal degeneration. Dynamin-related protein 1 (Drp1)-mediated abnormalities in mitochondrial dynamics are involved glaucoma pathogenesis; however, little known about the precise pathways regulate injury...
Abstract Fatty acid binding proteins (FABPs) are a class of small molecular mass intracellular lipid chaperone that bind to hydrophobic ligands, such as long‐chain fatty acids. FABP5 expression was significantly upregulated in the N ‐methyl‐ d ‐aspartic (NMDA) model, microbead‐induced chronic glaucoma and DBA/2J mice. Previous studies have demonstrated can mediate mitochondrial dysfunction oxidative stress ischemic neurons, but role cell death retina NMDA injury models is unclear. In this...
Glaucoma is the leading cause of blindness worldwide. However, our insufficient understanding pathogenesis glaucoma has limited development effective treatments. Because recent research highlighted importance non-coding RNAs (ncRNAs) in various diseases, we investigated their roles glaucoma. Specifically, detected expression changes ncRNAs cell and animal models acute Further analysis revealed that Ier2/miR-1839/TSPO axis was critical to loss retinal damage. The knockdown Ier2,...
Introduction In recent years, the biological functions and important roles of long non-coding RNAs (lncRNAs) have been widely reported in many diseases. Although glaucoma is leading cause blindness worldwide, specific mechanisms lncRNAs pathogenesis progression remain unclear. Our research aims to elucidate differentially expressed mRNAs provide a basis for further exploration mechanism action glaucoma. Methods We performed RNA sequencing on samples from pressurized model R28 cells...