A5025189071- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Head and Neck Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- interferon and immune responses
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Systemic Lupus Erythematosus Research
- Congenital Diaphragmatic Hernia Studies
- RNA Research and Splicing
- Renal Diseases and Glomerulopathies
- Electrochemical Analysis and Applications
- Ear and Head Tumors
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Salivary Gland Tumors Diagnosis and Treatment
- Nanotechnology research and applications
- NF-κB Signaling Pathways
University of Oklahoma Health Sciences Center
2016-2023
Oklahoma Medical Research Foundation
2019-2022
Chittaranjan National Cancer Institute
2008-2017
University of Kalyani
2014-2015
Texas Tech University Health Sciences Center
2015
Texas Tech University
2015
The aim of this study is to understand the mechanism EGFR overexpression in head and neck squamous cell carcinoma (HNSCC). For reason, expression/mutation were analyzed 30 dysplastic lesions 148 HNSCC samples Indian patients along with 3 lines. In addition, deletion/methylation/mutation/expression SH3GL2 (associated degradation) CDC25A dephosphorylation EGFR) same set samples. Our revealed high frequency (66–84%), low gene amplification (10–32.5%) absence functional mutation No correlation...
For the first time, a hydrazinopyrimidine based chemosensor has been designed for sensing Al<sup>3+</sup> through CHEF-PET-ESIPT fluorescence mechanisms and by building an ‘INHIBIT’ molecular logic gate.
4-Methyl-2-((quinolin-6-ylimino)methyl)phenol and 4-methyl-2-((quinolin-2-ylimino)methyl)phenol have been found to be dual fluorescence chemosensors for Al<sup>3+</sup> Zn<sup>2+</sup> ions, but their sensing ability varies.
A selective fluorescence chemosensor for Zn<sup>2+</sup> has been developed with a very low limit of detection value (0.832 nM).
A new pyridoxal-based chemosensor (<bold>PydDmen</bold>) was reported for selective detection of Zn<sup>2+</sup> in solution. The experimental and theoretical supports are provided to establish induced transformation <bold>PydDmen</bold> 3-pyridone tautomeric form.
Abstract The aim of our study was to analyze the alterations some candidate tumor suppressor genes (TSGs) viz. LIMD1 , LTF CDC25A SCOTIN RASSF1A and CACNA2D2 located in chromosomal region 3p21.31 associated with development early dysplastic lesions head neck. In analysis 72 116 squamous cell carcinoma neck, both deletion promoter methylation have been seen these except for where no has detected. alteration highest (50%) mild did not change significantly during progression indicating its...
Abstract To understand the association of candidate tumour suppressor genes SH3GL2 , p 16 INK 4 a 14 ARF and 15 b in pathogenesis head neck squamous cell carcinoma (HNSCC), we studied deletion, mutation, methylation these 61 dysplastic lesions 94 HNSCC samples. In mild dysplasia, showed higher frequency overall alterations (60–70%) than (40%). However, subsequent stages progression, alteration did not change significantly. One novel mutation common exon 2 / three 9 were seen. Concordance was...
To understand the association between candidate tumor suppressor genes (TSGs) human mismatch repair protein homologue 1 (hMLH1), AP20 region gene (APRG1), integrin alpha RLC (ITGA9), RB1 serine phosphates from chromosome 3 (RBSP3) at chromosomal 3p22.3 and development of head neck squamous cell carcinoma (HNSCC), alterations (deletion/promoter methylation/expression) these were analyzed in 65 dysplastic lesions 84 HNSCC samples. Clinicopathological correlations made with genes. In HNSCC,...
Polymorphic variants of DNA repair and damage response genes play major role in carcinogenesis. These are suspected as predisposition factors to Oral Squamous Cell Carcinoma (OSCC). For identification susceptible affecting OSCC development Indian population, the "maximally informative" method SNP selection from HapMap data non-HapMap populations was applied. Three hundred twenty-five SNPs 11 key involved double strand break repair, mismatch pathways were genotyped on a total 373 OSCC, 253...
In a recent genome-wide association study, significant genetic between rs34330 of CDKN1B and risk systemic lupus erythematosus (SLE) in Han Chinese was identified. This study undertaken to validate the reported elucidate biochemical mechanisms underlying effect variant.We performed an allelic analysis patients with SLE, followed by meta-analysis assessing data across 11 independent cohorts (n = 28,872). silico bioinformatics experimental validation SLE-relevant cell lines were applied...
Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O2-) levels with increased accumulation of hydrogen peroxide (H2O2) CLL cells vs. normal B-cells. Further analysis indicated that mitochondrial dismutase (SOD)2, which converts O2- into H2O2 remained deacetylated due to SIRT3 overexpression resulting its constitutive activation. In addition, catalase expression was also reduced...
Abstract Introduction To understand the role of two interacting proteins LIMD1 and pRB in development head neck squamous cell carcinoma (HNSCC), alterations these genes were analyzed 25 dysplastic lesions, 58 primary HNSCC samples lines. Methods Deletions RB1 along with mutation promoter methylation analysis LIMD1. The genotyping linked microsatellite marker, hmlimD1, was done to find out any risk allele. mRNA expression by Q-PCR. Immunohistochemical performed. Alterations correlated...
High concentrations of oxygen (hyperoxia) are routinely used during anesthesia, and supplemental is also administered in connection with several other clinical conditions. Although prolonged hyperoxia known to cause acute lung injury (ALI), whether short-duration causes toxicity remains unknown. We exposed mice room air (RA or 21% O 2 ) 60% alone combination 2% isoflurane for h determined the expression oxidative stress marker genes, DNA damage repair cell cycle regulatory proteins using...
The protein SLIT2 and its receptor ROBO1 regulate different cellular processes, such as proliferation, apoptosis, migration. In this study our aim is to understand the alterations of these genes during development head neck squamous cell carcinoma (HNSCC).First, molecular were analyzed in 30 dysplastic lesions, 128 primary HNSCC samples, 1 line. Then correlated with mRNA expression (n = 22) 29). Finally, clinicopathologic parameters clinical outcomes patients.ROBO1 had a comparatively high...
The aim of this study was to cast light on initiating molecular events associated with the development premalignant oral lesions induced by tobacco and/or areca nut.Immunohistochemical analyses cell cycle regulatory proteins (LIMD1, RBSP3, p16, RB, phosphorylated p53), EGFR and SH3GL2 (EGFR protein) were performed inflammatory/ ulcerative epithelium adjacent hyperplastic/mild dysplastic lesions.No change in expression seen inflammatory epithelium. Reduced nuclear LIMD1 evident In...
Neoadjuvant chemotherapy (NACT) is a treatment modality whereby used as the initial of HNSCC in patients presenting with advanced cancer that cannot be treated by other means. It leads to shrinkage tumours an operable size without significant compromise essential oro-facial organs patients. The molecular mechanisms behind due NACT not well elucidated.