A5029355120- Advanced Topics in Algebra
- Holomorphic and Operator Theory
- Marine Sponges and Natural Products
- Auction Theory and Applications
- Synthetic Organic Chemistry Methods
- Matrix Theory and Algorithms
- Consumer Market Behavior and Pricing
- Spectral Theory in Mathematical Physics
- Advanced Algebra and Logic
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Algorithms and Data Compression
- Peer-to-Peer Network Technologies
- Chemical Synthesis and Analysis
- Advanced Operator Algebra Research
- Error Correcting Code Techniques
- Microbial Natural Products and Biosynthesis
- Advanced Algebra and Geometry
- Oxidative Organic Chemistry Reactions
- Synthesis and Catalytic Reactions
- Digital Platforms and Economics
- Biofuel production and bioconversion
- Cancer Treatment and Pharmacology
- Multimedia Communication and Technology
Shanghai Institute of Technology
2012-2024
Louisiana State University Health Sciences Center New Orleans
2019-2022
Shaanxi Normal University
2009-2020
Fudan University
2009-2020
Google (United States)
2020
Hebei University
2020
Shanghai Institute of Materia Medica
2020
Academia Sinica
2020
Shanghai Stomatological Hospital
2020
Minhang District Central Hospital
2020
Structure-based design and synthesis of a number potent selective memapsin 2 inhibitors are described. These were designed based upon the X-ray structure 2-bound inhibitor 3 that incorporates methylsulfonyl alanine as P2-ligand substituted pyrazole P3-ligand. Of particular importance, we examined ability isophthalic acid amide derivative to mimic key interactions in S2−S3 regions enzyme active sites 3-bound 2. We investigated various phenylethyl, α-methylbenzyl, oxazolylmethyl groups...
An enantioselective total synthesis of (+)-peloruside A (1) is described. Peloruside a potent microtubule stabilizer with significant clinical potential. The convergent and involves the assembly C1−C10 segment 2 C11−C24 3 by novel aldol protocol followed Yamaguchi macrolactonization resulting seco-acid, selective methylation hemi-ketal removal protecting groups to peloruside A.
Peloruside B (2), a natural congener of peloruside A (1), was isolated in sub-milligram quantities from the New Zealand marine sponge Mycale hentscheli. promotes microtubule polymerization and arrests cells G2/M phase mitosis similar to paclitaxel, its bioactivity comparable that A. NMR-directed isolation, structure elucidation, confirmation by total synthesis, are described this article. The synthesis features Sharpless dihydroxylation, Brown's asymmetric allylboration reaction, reductive...
[structure: see text] An enantioselective total synthesis of (-)-spongidepsin (2) and elucidation the absolute stereochemistry its four stereocenters are described. Spongidepsin (2), a 13-membered depsipeptide isolated from Vanuatu marine sponge Spongia sp., has shown potent antitumor properties against variety NCI tumor cell lines. Our is convergent, five chiral centers was assigned through synthesis.
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTL-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive MoleculesArun K. Ghosh*, Jorden Kass, David D. Anderson, Xiaoming Xu, and Christine MarianView Author Information Departments of Chemistry Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907[email protected]Cite this: Org. Lett. 2008, 10, 21, 4811–4814Publication Date (Web):October 3, 2008Publication...
We used synthetic peloruside A for the commercial preparation of [3H]peloruside A. The radiolabeled compound bound to preformed tubulin polymer in amounts stoichiometric with polymer's content, an apparent Kd value 0.35 μM. less active analogue, (11-R)-peloruside and laulimalide acted as competitive inhibitors binding A, Ki values 9.3 0.25 μM, respectively. Paclitaxel, epothilone B, discodermolide had essentially no ability inhibit binding, confirming that these compounds bind a different...
The 1,2,3-triazole-containing polycyclic architecture widely exists in a broad spectrum of synthetic bioactive molecules, and the development expeditious methods to synthesize these skeletons remains challenging task. In this work, catalytic cyclization biomass-derived 2-furylcarbinols with an azide form fused triazoles is described. This approach takes advantage single catalyst Yb(OTf)3 operates via furfuryl-cation-induced intramolecular [3 + 2] cycloaddition/furan ring-opening cascade.
A TiCl4-promoted cascade formal [3 + 2] cycloaddition/double ring-opening/chlorination of 2-furylcyclobutanols with alkyl or aryl azides is described. This highly efficient transformation involves the formation/cleavage several C-N, C-Cl, C-C, and C-O bonds in a single operation. It enables quick construction trisubstituted 1,2,3-triazoles an ( E)-enone moiety 3-chloropropyl unit. The chlorinated products are readily transformed into other structurally diverse analogues.
Bounded observables corresponding to a quantum system are usually represented by S(H), the set of all bounded linear self-adjoint operators on Hilbert space H. In 2006, Gudder introduced logic order, ≼, S(H). For A,B∊S(H), A≼B if and only there exists C∊S(H) such that AC=0 A+C=B. Given let A∨B be least upper bound (supremum) for A B with respect order. 2007, Pulmannová Vincenková proved have an this paper, we present some new necessary sufficient conditions which give explicit representation...
14S,22-Dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (maresin-L1) and 14R,22-dihydroxy-docosa-4Z,7Z,10Z, 12E,16Z,19Z-hexaenoic (maresin-L2) were chemically synthesized. They identical to activated macrophage-produced counterparts their total synthesis was highly stereoselective, as revealed by chiral LC-UV-MS/MS analysis. The involved the following steps: (1) kinetic resolution of a racemic allylic alcohol asymmetric epoxidation; (2) transformation epoxy γ-hydroxyenal derivative; (3)...
We construct prior-free auctions with constant-factor approximation guarantees ordered bidders, in both unlimited and limited supply settings. compare the expected revenue of our on a bid vector to monotone price benchmark, maximum that can be obtained from using supply-respecting prices are nonincreasing bidder ordering bounded above by second-highest bid. As consequence, simultaneously near-optimal wide range Bayesian multi-unit environments.
A furfuryl cation induced three‐component thioesterification reaction between thiols, 5‐bromo‐2‐furylcarbinols and azides is reported. This metal‐free method relies on the acetyl chloride/HFIP‐mediated cascade formal [3+2] cycloaddition/ring‐opening/thioesterification, which allows efficient construction of a series complex triazole‐thioesters linked with an ( Z )‐olefin. Selenols are also suitable for this strategy. Further derivatization thioesters highlighted potential utility our method.