A5017368792- Synthesis and biological activity
- Enzyme Structure and Function
- Erythrocyte Function and Pathophysiology
- Agricultural pest management studies
- Computational Drug Discovery Methods
- Genetic and Environmental Crop Studies
- Click Chemistry and Applications
- Bacterial Genetics and Biotechnology
- Protein Structure and Dynamics
- Synthesis of Organic Compounds
- Pharmacological Effects and Assays
- Synthesis and Biological Evaluation
- Asthma and respiratory diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Plant Virus Research Studies
- Multicomponent Synthesis of Heterocycles
- Trypanosoma species research and implications
- Bacteriophages and microbial interactions
- Legume Nitrogen Fixing Symbiosis
- Biochemical and Molecular Research
- Tuberculosis Research and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Nitric Oxide and Endothelin Effects
- Aldose Reductase and Taurine
- Advanced Glycation End Products research
Osmania University
2015-2024
Indian Institute of Science Bangalore
2007-2019
Institute of Medicinal Molecular Design
2017
University of Hyderabad
2014-2017
Globally, chickpea production is severely affected by salinity stress. Understanding the genetic basis for tolerance important to develop tolerant chickpeas. A recombinant inbred line (RIL) population developed using parental lines ICCV 10 (salt-tolerant) and DCP 92-3 (salt-sensitive) was screened under field conditions collect information on agronomy, yield components, stress indices. Genotyping data generated Axiom®CicerSNP array used construct a linkage map comprising 1856 SNP markers...
Chickpea production is vulnerable to drought stress. Identifying the genetic components underlying adaptation crucial for enhancing chickpea productivity. Here, we present fine mapping and characterization of 'QTL-hotspot', a genomic region controlling growth with positive consequences on crop under drought. We report that non-synonymous substitution in transcription factor CaTIFY4b regulates seed weight organ size chickpea. Ectopic expression Medicago truncatula enhances root water deficit....
'QTL-hotspot' is a genomic region on linkage group 04 (CaLG04) in chickpea (Cicer arietinum) that harbours major-effect quantitative trait loci (QTLs) for multiple drought-adaptive traits, and it therefore represents promising target improving drought adaptation. To investigate the mechanisms underpinning positive effects of seed yield under drought, we introgressed this from ICC 4958 genotype into five elite cultivars. The resulting introgression lines (ILs) their parents were evaluated...
The COVID-19 disease is caused by SARS-CoV-2 and spreading rapidly worldwide with extremely high infection rate. Since effective specific vaccine not available to combat the deadly COVID-19, objective of our study was design a multi-epitope using immunoinformatics approach translational implications. Nucleocapsid (N) protein stable, conserved highly immunogenic along being less prone mutations during infection, which makes it suitable candidate for designing vaccine. In study, B- T-cells...
Mammalian target of rapamycin (mTOR) is a key regulator cell growth, proliferation and angiogenesis.mTOR signaling frequently hyper activated in broad spectrum human cancers thereby making it potential drug target.The current drugs available have been successful inhibiting the mTOR signaling, nevertheless, show low oral bioavailability suboptimal solubility.Considering narrow therapeutic window inhibitors, through computational approaches, present study pursues to identify compound with...
Abstract Genetic enhancement for resistance against the pod borer, Helicoverpa armigera is crucial enhancing production and productivity of chickpea. Here we provide some novel insights into genetic architecture natural variation in H. chickpea, an important legume, which plays a major role food nutritional security. An interspecific recombinant inbred line (RIL) population developed from cross between susceptible accession ICC 4958 ( Cicer arietinum ) resistant PI 489777 reticulatum was...
Abstract Isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. Their biosynthesis is initiated by two enzymes with unusual catalytic activities; 2-hydroxyisoflavanone synthase (2-HIS), membrane-bound cytochrome P450 catalyzing coupled aryl-ring migration hydroxylation, dehydratase (2-HID), member large carboxylesterase family that paradoxically catalyzes dehydration 2-hydroxyisoflavanones to isoflavone. Here we report the...
A series of 2′-substituted-3′-methylspiro[cyclohexane-1,7′-furo[3,2-<italic>g</italic>]chroman]-5′(7′<italic>H</italic>)-one, <bold>5a–i</bold> and <bold>7a–u</bold> have been synthesized using an eco-friendly approach with good anti-inflammatory antioxidant activity.
Based on the earlier proven pharmacophore analogues of cancer a novel 2-(substituted-2<italic>H</italic>-chromen-3-yl)-5-aryl-1<italic>H</italic>-imidazoles were rationally designed, synthesized and used for competitive biological activity against cell lines.
Phosphomannose isomerase (PMI) is a housekeeping enzyme that found in organisms ranging from bacteria to fungi mammals and important for cell-wall synthesis, viability signalling. PMI zinc-dependent catalyses the reversible isomerization between mannose 6-phosphate (M6P) fructose (F6P), presumably via formation of cis-enediol intermediate. The reaction hypothesized involve ring opening M6P, transfer proton C2 atom C1 O1 O2 atoms substrate, followed by closure resulting product F6P. Several...
Graphical Abstract Schematic diagram showing the differential responses of NCS BG II BT and Non varities to drought stress. variety showed better tolerance compared with plant variety.
A series of new phosphorylated derivatives thiazolidinedione was synthesized for the first time with high yields (92–96%) in short reaction (7–15min) by 4-{[(5E)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenyl ethyl phosphorochloridate various heterocyclic amines microwave irradiation technique under solvent-free condition. study on silico ADMET and molecular docking performed all molecules to acquire an insight drug likeliness behavior also their ability inhibit enzyme, α-amylase. The...
Tuberculosis (TB) stands as the second most fatal infectious disease globally, causing 1.3 million deaths in 2022. The resurgence of TB and alarming rise antibiotic resistance demand urgent call to develop novel antituberculosis drugs. Despite concerted efforts control TB, persists spreads rapidly on a global scale. Targeting stress response pathways Mycobacterium tuberculosis (Mtb) has become imperative achieve complete eradication. This study employs subtractive genomics identify...