A5047690576- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastroesophageal reflux and treatments
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Enhanced Recovery After Surgery
- Inflammatory Bowel Disease
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Dysphagia Assessment and Management
- Hernia repair and management
- Nutrition and Health in Aging
- Anesthesia and Pain Management
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Anorectal Disease Treatments and Outcomes
- Intestinal and Peritoneal Adhesions
- IL-33, ST2, and ILC Pathways
- Intraperitoneal and Appendiceal Malignancies
- Pelvic and Acetabular Injuries
- Gastrointestinal disorders and treatments
- Cancer Treatment and Pharmacology
Baylor College of Medicine
2019-2025
Abbott (Sweden)
2023-2024
Allama Iqbal Medical College
2024
University of Science and Technology Bannu
2024
Birmingham General Hospital
2024
Russells Hall Hospital
2024
Jinnah Postgraduate Medical Center
2023-2024
NRG Oncology
2020-2023
Florida College
2013-2022
University of Florida
2013-2022
5 Background: For patients (pts) with colon cancer (CC), the detection of circulating tumor DNA (ctDNA) is associated persistent disease after resection and outperforms traditional clinical pathological features in prognosticating recurrence risk. We hypothesized that for pts low-risk stage II CC, a positive ctDNA status may identify those who benefit from adjuvant chemotherapy. Methods: In this prospective phase II/III trial, resected CC without high risk whom evaluating oncologist deems...
The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that biology this cohort may differ, study compared survival patterns, stratifying according to National Comprehensive Cancer Network (NCCN) guideline-driven care and age.The Data Base was queried for treated with curative-intent transabdominal resections negative surgical margins stage I III between 2004 2014. Outcomes overall old or older were by subgroups based on NCCN care.A total...
Inflammatory bowel disease (IBD) continues to increase in prevalence industrialized countries. Major complications of IBD include formation fibrotic strictures, fistulas, reduced absorptive function, cancer risk, and the need for surgery. In other chronic gastrointestinal models, stiffness has been shown precede fibrosis; therefore, may be a reasonable indicator progression toward stricture patients. Herein, we seek quantify tissue characterize fibrosis patients with compare mechanical...
To assess whether reoperative surgery for failed Nissen fundoplication is beneficial and to classify all mechanisms of failure recognized.Antireflux often necessary, but a 10% rate commonplace. We report results patients undergoing present nomenclature failure.A total 104 patients, who had previous gastroesophageal reflux disease (GERD), underwent surgery. Manometry (n = 86), endoscopy 101), pH monitoring 27), upright esophagram 90), gastric emptying 26), symptom assessment 104) were...
Dehydration is a common complication after ileostomy creation and the most frequent reason for postoperative readmission to hospital. We sought determine clinical economic impact of an outpatient intervention decrease readmissions dehydration creation.All new ileostomates from 09/2011 through 10/2012 at University Florida were enrolled receive education management protocol daily telephone call 3 weeks discharge. Counseling medication adjustments provided, with satisfaction survey end....
Laparoscopic Heller myotomy for achalasia has a 10-20% failure rate and may require re-operation to control persistent or recurrent symptoms. We report follow-up of 15 patients who underwent laparoscopic failed myotomy. Between 1993 2004, at our center. The mean duration between procedures was 23 months. Follow-up completed 30 months in 14 (93%) via telephone questionnaire. Our overall primary surgery (n = 106) 5.6%. mechanisms were incomplete (33%), fibrosis (27%), fundoplication disruption...
Crohn's disease (CD) is a chronic inflammatory condition of the human gastrointestinal tract whose aetiology remains largely unknown. Dysregulated adaptive immune responses and defective innate immunity both contribute to this process. In study, we demonstrated that interleukin (IL)-17A+ interferon (IFN)-γ+ IL-22+ IFN-γ+ T cell subsets accumulated specifically in inflamed terminal ileum CD patients. These cells had higher expression Ki-67 were active cytokine producers. addition, their...
Deregulation of various components the immune system has been reported in inflamed gut Crohn's disease (CD) patients. Innate lymphoid cells (ILCs) are novel innate effector lymphocytes which can rapidly respond to danger signals, from invading pathogens or tissue damage, maintain homeostasis, especially along mucosal surfaces. The purpose this study is compare composition intestinal ILCs subsets CD patients with differential inflammatory conditions terminal ileum, marked by distinct...
Anaesthesiologists prefer regional anesthesia for ureterorenoscopy to prevent difficulties after the procedure, whereas surgeons general in order ureteral damage. However, limited comparative data exist regarding outcomes of these techniques ureteroscopy-assisted stone clearance Objective: To compare spinal and efficacy, safety, patient during ureteroscopy ureteric stones. Methods: This quasi-experimental study included 90 patients aged between 20-60 years total were chosen. Using a...
BACKGROUND: New ileostomates have higher rates of dehydration and readmission compared to patients undergoing other colorectal procedures. OBJECTIVE: We aimed show the efficacy a novel ileostomy-specific quality improvement protocol at an academic center with subsequent validation another center. DESIGN: Prospective cohort study. SETTING: Baylor College Medicine (Houston, TX) University Florida Health (Gainesville, Florida). PATIENTS: Patients who underwent elective ileostomy creation were...
Despite major advances in the medical management of Crohn's disease (CD), a significant proportion patients will require surgery within 5 years diagnosis. Malnutrition is an independent risk factor for adverse post-operative outcomes following gastrointestinal surgery. Data on value pre-operative total parenteral nutrition (TPN) CD are mixed and there paucity data biologic era. We aimed to define role TPN this population. This was retrospective cohort study conducted at tertiary referral...