A5101907702- Thyroid Cancer Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine Tumor Research Advances
- Dermatologic Treatments and Research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Facial Rejuvenation and Surgery Techniques
- Cancer-related Molecular Pathways
- Wound Healing and Treatments
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Brain Metastases and Treatment
- Dental Anxiety and Anesthesia Techniques
- Metabolomics and Mass Spectrometry Studies
- High Entropy Alloys Studies
- Lymphatic System and Diseases
- Lung Cancer Research Studies
- Tattoo and Body Piercing Complications
- Complement system in diseases
- Lung Cancer Treatments and Mutations
- Cardiac Arrest and Resuscitation
- Galectins and Cancer Biology
- Parkinson's Disease and Spinal Disorders
- Myofascial pain diagnosis and treatment
- Renal Diseases and Glomerulopathies
Anyang Hospital of Traditional Chinese Medicine
2025
Peking University Shenzhen Hospital
2021-2024
Third People's Hospital of Hefei
2023
Hebei Medical University
2018-2023
Fourth Hospital of Hebei Medical University
2018-2023
Zhejiang Cancer Hospital
2019-2020
Sanya Central Hospital
2019
Fudan University
2016
Xiangya Hospital Central South University
2007
Central South University
2007
The rapid development of cosmetic injections has led to an increased incidence nontuberculous mycobacterial (NTM) infection.
Metabolomics and 16S rDNA sequencing have shown great potential in elucidating complex mechanisms associated with diseases. Currently, there is little research on the omics of gastric cancer it lacks effective biomarkers. Based plasma metabolomics to evaluate changes metabolites fecal microbiota advanced cancer. Firstly, was used screen for differential metabolic pathways Then, performed samples study intestinal patients. Finally, conduct a correlation analysis between them. A total 152 were...
Background . This study was aimed at exploring the effects of miR-215 and its target gene stearoyl-CoA desaturase (SCD) on colorectal cancer (CRC) cell migration invasion. Methods Here, we analyzed relationship between SCD, as well regulation CRC cells. We constructed wild-type mutant plasmids SCD to identify whether a by using luciferase reporter assay. The expression detected quantitative real-time polymerase chain reaction (qRT-PCR) western blot, respectively. MTT, wound healing,...
Platelet-rich plasma (PRP) is gaining more and attention in regenerative medicine as an innovative efficient therapeutic approach. The properties of PRP rely on the numerous bioactive molecules released by platelets: growth factors are involved proliferation differentiation endothelial cells fibroblasts, angiogenesis extracellular matrix formation, while cytokines mainly immune cell recruitment inflammation modulation. Attempts ongoing to improve potential combining it with agents able...
Abstract Apoptosis plays a key role in keloids. Growth arrest and DNA damage‐inducible gene 153 (GADD153) is regulated by apoptosis. Botulinum toxin type A (BTXA) can induce apoptosis keloid fibroblasts. This research aimed to explore the hypothesis that GADD153 mediates fibroblasts exposed BTXA. BTXA significantly induced protein mRNA expression Treatment with c‐Jun N‐terminal kinase (JNK) inhibitor SP600125, JNK small interfering RNA (siRNA) tumour necrosis factor‐alpha (TNF‐α) antibodies...
Purpose: To evaluate the possible roles of miR-34a expression in thyroid lesions, to unravel correlation between fluorodeoxyglucose (FDG) uptake and moreover, discover underlying mechanisms by which regulates FDG avidity. Methods: We retrospectively reviewed 75 patients with pathology-confirmed diseases who underwent 18 F-FDG positron emission tomography/computed tomography (PET/CT) within 3 months before undergoing surgery analysis from June 2012 July 2017. lesions was also analyzed...
Correlation between RAS gene mutation and microsatellite instability (MSI) status in cancer tissues clinicopathological parameters of patients with stage Ⅲ colorectal (CRC) were investigated. Tissues collected from 180 diagnosed CRC the Department Gastrointestinal Surgery Fourth Hospital Hebei Medical University 2012 to 2016. mutations paraffin sections detected by PCR Sanger sequencing. Expression mismatch repair proteins MLH1, MSH2, MSH6 PMS2 was immunohistochemistry, MSI determined based...
The effect of intra-operative chemotherapy (IOC) on the long-term survival patients with colorectal cancer (CRC) remains unclear. In this study, we evaluated independent infusion 5-fluorouracil in combination calcium folinate CRC following radical resection.1820 were recruited, and 1263 received IOC 557 did not. Clinical demographic data collected, including overall (OS), clinicopathological features, treatment strategies. Risk factors for IOC-related deaths identified using multivariate Cox...
Abstract Background Owing to its safety and convenience, botulinum toxin type A (BoNtA) has become a first‐choice treatment for contouring calf muscle asymmetries or deformities. Different injection methods dosages have been discussed in the literature, but standardized BoNtA remains unclear. Aims This study aimed classify gastrocnemius hypertrophy (GMH) through multiple measurements provide personalized protocol. Methods The combining of (GM) contour, max leg circumference GM thickness was...
The clinical characteristics and RET proto-oncogene (RET‑PO) mutation status of a patient with multiple endocrine neoplasia type 2A pedigree (MEN2A) was analyzed the aim preliminarily exploring molecular mechanisms significance disease. Clinical single MEN2A were analyzed. Genomic DNA extracted from peripheral blood proband 10 family members. 21 exons RET‑PO PCR amplified products sequenced. Of members, 5 exhibited C634Y (TGC→TAC) missense in exon 11 RET‑PO, among which 2 members screened as...
As a minimally invasive therapy, botulinum toxin A (BTXA) treatment effectively reduces the hypertrophy of gastrocnemius muscle (GM). Patient satisfaction is, however, reported to be low after treatment, with possible correlation between high and thinner subcutaneous fat. The goal this study was classify fat calves understand relation thickness patient BTXA treatment.
A 41 year old man presented with a familial history of multiple endocrine neoplasia type 2A (MEN2A) and severe hypertension. Rearranged during transfection (RET) gene sequencing confirmed Cys634Tyr mutation TGC to TAC. Total thyroidectomy bilateral neck dissection were performed the pathological assessment revealed medullary thyroid carcinoma (MTC), 0.6 cm in size on right side (number lymph nodes: 0/2, 0/15, 0/12, 0/8 areas VI, II, III, IV, respectively) papillary (PTC), 0.2 left (numbers...
Objective To screen the RET gene mutation in a pedigree of multiple endocrine neoplasia type 2A (MEN2A). Methods Clinical data 21 members MEN2A family were collected from June 1976 to February 2013. Systemic clinical investigations including biochemical testing, imaging examinations and germline screening performed. Results RET showed heterozygous missense mutations cysteine tyrosine at codon 634 on exon 11 10 patients (p.C634Y, 10/21) 8 males 2 females, which completely...
Abstract Background: The formation of keloids is influenced by various factors, with local mechanical stretch being recognized as a significant contributing component. Thrombospondin-1 (TSP-1) identified tension-sensitive protein. However, the relationship between TSP-1 and keloid induced remains unknown. Materials Methods: A simple customized device was used for application homogeneous equibiaxial (HES). Using Western blot RT-PCR, optimal strength duration were determined. Regarding...
Objective To investigate the expression of Nectin-4 and to analyze its clinical significance. Methods The immunohistochemistry assay tissue micro-array were used examine in human EC tissues as well adjacent normal tissues. The correlation between level Nectin-4and patients’ clinic pathological parameters was evaluated by using chi-square test. cell lines Eca-109 TE-1 construct stable knockdown or overexpression RNA interference (RNAi) method. counting kit-8 (CCK-8), wound healing,...
Objective To investigate the clinical significance and biological function of human endogenous retrovirus subfamily H long terminal repeat associating protein 2 (HHLA2) in clear cell renal carcinoma (ccRCC). Methods Down-regulation HHLA2 was performed by using RNA interference (RNAi) method to role regulation behaviors lines 786-O ACHN. The counting kit-8 (CCK-8) assay, wound healing transwell invasion assay were used examine cellular after knockdown these cells. We also identified...
Objective To study the clinical application of intercalated combination osimertinib and docetaxel in T790M mutation-positive lung adenocarcinoma patients with bone metastasis southern Hainan Province. Methods T790M sou-thern Province treated at Third People′s Hospital from January 2018 to October were enrolled, they divided into group (n=32) (n=28) according treatment. The received oral (80 mg, qd), (75 mg/m2, repeated three-week intervals) when taking tumor progression, treatment qd)...