A5100599712- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Plant Disease Resistance and Genetics
- Genetic and phenotypic traits in livestock
- Advanced biosensing and bioanalysis techniques
- Legionella and Acanthamoeba research
- Chromosomal and Genetic Variations
- Colorectal Cancer Treatments and Studies
- Animal Virus Infections Studies
- Cancer-related gene regulation
- Biosensors and Analytical Detection
- Plant biochemistry and biosynthesis
- RNA regulation and disease
- Magnetic and Electromagnetic Effects
- DNA and Nucleic Acid Chemistry
- Bacteriophages and microbial interactions
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Peking University
2025
Center for Life Sciences
2025
Yichang Central People's Hospital
2024
China Three Gorges University
2024
Second Hospital of Yichang
2024
Southwest University
2010-2024
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
Pork quality is an economically important trait and one of the main selection criteria for breeding in swine industry.In this genome-wide association study (GWAS), 455 pigs from a porcine Large White × Minzhu intercross population were genotyped using Illumina PorcineSNP60K Beadchip, phenotyped intramuscular fat content (IMF), marbling, moisture, color L*, a*, b* score longissimus muscle (LM).Association tests between each SNPs performed via Genome Wide Rapid Association Mixed Model...
Secondary cell wall (SCW) is an important industrial raw material for pulping, papermaking, construction, lumbering, textiles and potentially biofuel production. The process of SCW thickening cotton fibers lays down the cellulose that will constitute bulk (up to 96%) fiber at maturity. In this study, a gene encoding MYB-domain protein was identified in (Gossypium hirsutum) designated as GhMYBL1. Quantitative real-time polymerase chain reaction (RT-PCR) analysis revealed GhMYBL1 specifically...
Spermatogenesis requires a large number of proteins to be properly expressed at certain stages, during which post-transcriptional regulation plays an important role. RNA-binding (RBPs) are key players in regulation, but only few RBPs have been recognized and preliminary explored their function spermatogenesis present. Here we identified new RBP tubby-like protein 2 (TULP2) found three potential deleterious missense mutations Tulp2 gene dyszoospermia patients. Therefore, the mechanism TULP2...
Cyclospora cayetanensis is an emerging coccidian parasite that causes endemic and epidemic diarrheal disease called cyclosporiasis, this infection associated with consumption of contaminated produce or water in developed developing regions. Food-borne outbreaks cyclosporiasis have occurred almost every year the USA since 1990s. Investigations these are currently hampered due to lack molecular epidemiological tools for trace back analysis. The apicoplast C. cayetanensis, a relict...
Plant hybrid proline-rich proteins (HyPRPs) usually consist of an N-terminal signal peptide, a central domain, and conserved eight-cysteine motif C-terminal domain. In this study, one gene (designated as GhHyPRP4) encoding putative HyPRP was isolated from cotton cDNA library. Northern blot quantitative reverse transcriptase-polymerase chain reaction analyses revealed that GhHyPRP4 preferentially expressed in leaves. Under cold stress, expression significantly up-regulated leaves seedlings....
Traditional genome‐wide association studies (GWAS) have successfully detected genetic variants associated with schizophrenia. However, only a small fraction of heritability can be explained. Gene‐set/pathway‐based methods overcome limitations arising from single nucleotide polymorphism (SNP)‐based analysis, but most them place constraints on size which may exclude highly specific and functional sets, like macromolecules. Voltage‐gated calcium (Ca v ) channels, belonging to macromolecules,...
Antisense transcription of protein-coding genes has been increasingly recognized as an important regulatory mechanism gene expression. However, less is known about the extent and importance antisense noncoding genes. Here, we investigate breadth dynamics miRNAs, a class RNAs. Because transcript miRNA likely to form hairpin suitable substrate ADARs, which convert adenosine inosine in double-stranded RNAs, used A-to-I RNA editing ultrasensitive readout for miRNAs. Through examining unstranded...
Rationale: Turner syndrome is characterized by complete or partial loss of the second sex chromosome. In patients with syndrome, hypertension well described. However, literature regarding malignant scarce. Therefore, an accurate and timely diagnosis treatment are important. Patient concerns: A 13-year-old female presented to emergency department hypertension, headache, spraying vomiting, convulsion, consciousness. Considering her medical history, symptoms, auxiliary examination, secondary...
Abstract Vacuum ultraviolet photoionization of a gas‐phase oligonucleotide anion leads to the formation valence hole. This hole migrates towards an energetically favorable site where it can weaken bonds and ultimately lead bond cleavage. We have studied UV deprotonated oligonucleotides containing human telomere sequence dTTAGGG G‐quadruplex structures consisting four dTGGGGT single strands, stabilized by NH 4 + counter ions. The anions were confined in radiofrequency ion trap, interfaced...
Long noncoding RNA (lncRNA) KTN1 antisense 1 (KTN1-AS1) is a novel promoter in the progression of some cancers. However, knowledge its role lung adenocarcinoma still limited. The current study aimed to examine biological functions KTN1-AS1 and coexpressed protein adenocarcinoma. sequencing expression profiles from Cancer Genome Atlas (TCGA) database were downloaded evaluate protein, as well assess their prognostic values. correlation between DEP domain containing (DEPDC1) levels was verified...
Small to moderate gains in Pig fertility can mean large returns overall efficiency, and developing methods improve it is highly desirable.High rates depend on completion of successful pregnancies.To understand the molecular signals associated with pregnancy sows, expression profiling experiments were conducted identify differentially expressed genes ovary myometrium at different periods using Affymetrix Porcine GeneChip TM .A total 974, 1800, 335 710 transcripts identified during early (EP)...
With the development of human genome project, scientists have obtained a large number biological sequences which needed to be processed and analyzed. In this paper, we characterized relationship between virus host cell by using alignment-free sequence comparison statistics such as, D2S, D2*, Hao, Eu Ch. By comparison, acquired distributions K-tuple in tested species, here biology is short genes with length K. We used ROC curves analyze data DNA find an optimal statistic method. The show that...
Legionella is a Gram-negative bacterium, and pneumonia an atypical pneumonia, clinically similar to Streptococcus pneumoniae or other bacterial with respiratory symptoms as the most common clinical manifestation, but very few patients have predominantly GI symptom presentation, which often leads delayed treatment; timely effective standardized treatment has good prognosis, individual can develop mechanized pneumonia. Therefore, we report case of infection diarrhea first manifestation...