A5039493475- Extracellular vesicles in disease
- Atherosclerosis and Cardiovascular Diseases
- Ferroptosis and cancer prognosis
- Animal Vocal Communication and Behavior
- Alzheimer's disease research and treatments
- Retinal Development and Disorders
- Cellular transport and secretion
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Advanced Chemical Sensor Technologies
- Lipid Membrane Structure and Behavior
- Marine animal studies overview
- Olfactory and Sensory Function Studies
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Cholesterol and Lipid Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Animal Behavior and Reproduction
- MicroRNA in disease regulation
New York University
2014-2024
Nathan Kline Institute for Psychiatric Research
2018-2024
NYU Langone Health
2016-2022
Possession of the ε4 allele apolipoprotein E (APOE) is major genetic risk factor for late-onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, precise cause this increased AD not yet known. In order to gain a more comprehensive understanding APOE4's role in AD, we performed RNA-sequencing on an AD-vulnerable vs. AD-resistant brain region from aged APOE targeted replacement mice. This transcriptomics analysis revealed significant enrichment genes involved...
In addition to being the greatest genetic risk factor for Alzheimer's disease, expression of ɛ4 allele apolipoprotein E can lead cognitive decline during ageing that is independent amyloid-β and tau pathology. human post-mortem tissue mouse models humanized E, we examined impact E4 on brain exosomes, vesicles are produced within secreted from late-endocytic multivesicular bodies. Compared humans or mice homozygous risk-neutral ɛ3 show allele, whether heterozygous with an drives lower exosome...
Variation in environmental factors such as day length and social context greatly affects reproductive behavior the brain areas that regulate these behaviors. One is song songbirds, which males use to attract a mate during breeding season. In species absence of potential leads an increase number songs produced, while presence diminishes singing. Interestingly, although long days promote behavior, producing itself can incorporation new neurons regions controlling output. Social also affect...
ABSTRACT The polymorphic APOE gene is the greatest genetic determinant of sporadic Alzheimer's disease risk: APOE4 allele increases risk, while APOE2 neuroprotective compared with risk‐neutral APOE3 allele. neuronal endosomal system inherently vulnerable during aging, and exacerbates this vulnerability by driving an enlargement early endosomes reducing exosome release in brain humans mice. We hypothesized that protective effects are, part, mediated through pathway. Messenger RNA analyses...