A5032911877- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Click Chemistry and Applications
- Inflammasome and immune disorders
- Synthesis and Reactions of Organic Compounds
- Peptidase Inhibition and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Mast cells and histamine
- Chemical Synthesis and Analysis
- Histone Deacetylase Inhibitors Research
- Synthesis and Catalytic Reactions
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Degradation and Inhibitors
- bioluminescence and chemiluminescence research
- Synthesis and biological activity
- Eosinophilic Disorders and Syndromes
- Sphingolipid Metabolism and Signaling
- Metal-Catalyzed Oxygenation Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Chronic Myeloid Leukemia Treatments
GlaxoSmithKline (Germany)
2016
CellCentric (United Kingdom)
2007-2011
Springhouse
2002
New Frontier
1998
Systemic and cerebral inflammatory responses are implicated in the pathogenesis of obesity associated metabolic impairment. While NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3) inflammasome has been linked to obesity-associated inflammation, whether it contributes development or maintenance is unknown. We provide support for a direct role saturated fatty acids, such as palmitic acid, NLRP3 activating stimuli obese states. To investigate activation diet-induced (DIO) mice, we tested...
The NLRP3 inflammasome is a component of the innate immune system involved in production proinflammatory cytokines. Neurodegenerative disorders, including Alzheimer's disease, Parkinson's multiple sclerosis, and amyotrophic lateral have been shown to driven by activation. Diseases such as these with large unmet medical needs resulted an interest inhibiting potential pharmacological treatment, but date, no marketed drugs specifically targeting approved. Furthermore, requirement for...
The 2-oxoglutarate-dependent dioxygenase target class comprises around 60 enzymes including several subfamilies with relevance to human disease, such as the prolyl hydroxylases and Jumonji-type lysine demethylases. Current drug discovery approaches are largely based on small molecule inhibitors targeting iron/2-oxoglutarate cofactor binding site. We have devised a chemoproteomics approach combination of unselective active-site ligands tethered beads, enabling affinity capturing 40 different...
A library of 422 1-(2-thiazolyl)-5-(trifluoromethyl)pyrazole-4-carboxamides was prepared in five steps using solution-phase chemistry. The first step the synthesis reaction ethyl 2-ethoxymethylene-3-oxo-4,4,4-trifluorobutanoate with thiosemicarbazide, which is reported literature to afford a 1:1 mixture 1-thiocarbamoyl-5-(trifluoromethyl)pyrazole-4-carboxylate and 1-thiocarbamoyl-3-(trifluoromethyl)pyrazole-4-carboxylate. We reassigned structure product be single compound,...
A mild and convenient synthesis of 2-(methylaminomethyl)-4,5-dialkyl-1H-imidazoles is described. The procedure was used in the preparation 2-(methylaminomethyl)-4,5,6,7-tetrahydro-1H-benzimidazole 1 2-(methylaminomethyl)-4,5-dimethyl-1H-imidazole 2.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”