A5035131950- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Spinal Cord Injury Research
- Ion channel regulation and function
- Connexins and lens biology
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
University of Leeds
2011-2024
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show the afferent information undergoes dynamic filtering within dorsal root ganglion (DRG) this occurs at axonal bifurcations (t-junctions). Using synchronous vivo electrophysiological recordings from central processes of sensory neurons (in spinal nerve root), ganglionic transplantation GABAergic progenitor...
Sensory information arising from the upper neck is important in reflex control of posture and eye position. It has also been linked to autonomic cardiovascular respiratory systems. Whiplash associated disorders (WAD) cervical dystonia, which involve disturbance region, can often present with abnormalities oromotor, We investigated potential neural pathways underlying such symptoms. Simulating afferent activity by electrical stimulation second nerve a working heart brainstem preparation...
Connexin (Cx) proteins localized to neuronal and glial syncytia provide the ultrastructural components for intercellular communication via gap junctions. In this study, a Cx45 reporter mouse model in which coding sequence is substituted enhanced green fluorescent protein (eGFP) was used characterize expressing neurones within adult spinal cord. eGFP-immunoreactive (eGFP-IR) cells were at all rostro-caudal levels laminae I–III of dorsal horn (DH), areas associated with nociception. The rather...
Abstract Background Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially perfused working heart brainstem preparation (WHBP) rat. Recordings nerve activity were made from thoracic sympathetic chain phrenic nerve, while rate (HR) perfusion pressure also monitored in perfused, decerebrate, rat WHBP. MF was added to perfusate at 1 μM...
Chronically elevated sympathetic nervous activity underlies many cardiovascular diseases. Elucidating the mechanisms contributing to system output may reveal new avenues of treatment. The contribution gap junctional protein connexin 36 (Cx36) regulation and thus blood pressure heart rate was determined using a mouse with specific genetic deletion Cx36. Ablation Cx36 confirmed in preganglionic neurons Cx36-knockout (KO) mice. Telemetric analysis from conscious KO mice revealed higher variance...
ABSTRACT The sympathetic nervous system comprises one half of the autonomic and participates in maintaining homeostasis enabling organisms to respond an appropriate manner perturbations their environment, either internal or external. preganglionic neurons (SPNs) lie within spinal cord axons traverse ventral horn exit roots where they form synapses onto postganglionic neurons. Thus, these are last point at which central can exert effect enable changes outflow. This review considers degree...
Abstract Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here we show the afferent information undergoes dynamic filtering within dorsal root ganglion (DRG) and this occurs at axonal bifurcations (t-junctions). Using synchronous in vivo electrophysiological recordings from central processes of sensory neurons (in spinal nerve root), ganglionic transplantation GABAergic progenitor cells, optogenetics...