A5101460205- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Perovskite Materials and Applications
- Cardiac electrophysiology and arrhythmias
- Nicotinic Acetylcholine Receptors Study
- Luminescence Properties of Advanced Materials
- Neuroscience and Neural Engineering
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- Connexins and lens biology
- Luminescence and Fluorescent Materials
- Protein Kinase Regulation and GTPase Signaling
- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Photorefractive and Nonlinear Optics
- Neuropeptides and Animal Physiology
- Conducting polymers and applications
- Sleep and Wakefulness Research
- Trace Elements in Health
- Protist diversity and phylogeny
- Ferroelectric and Piezoelectric Materials
- Transition Metal Oxide Nanomaterials
Nankai University
2019-2025
Hebei Medical University
2016-2025
Shijiazhuang University
2021-2025
Unité Matériaux et Transformations
2024-2025
Weifang People's Hospital
2025
Center for Vascular Biology Research
2025
Northwest A&F University
2025
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2023-2025
Ministry of Education of the People's Republic of China
2013-2024
Northwest University
2024
Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing substances. When released at sites tissue damage or inflammation, applied exogenously, BK produces acute spontaneous pain causes hyperalgesia (increased sensitivity to potentially painful stimuli). The mechanisms underlying induced by are poorly understood. Here we report that in small nociceptive neurons from rat dorsal root ganglia, BK, acting through its B2 receptors, PLC, release calcium...
The activity of specific inwardly rectifying potassium (Kir) channels is regulated by any a number different modulators, such as protein kinase C, G(q) -coupled receptor stimulation, pH, intracellular Mg(2+) or the betagamma-subunits G proteins. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) an essential factor for maintenance all Kir channels. Here, we demonstrate that strength channel-PIP(2) interactions determines sensitivity to regulation various modulators. Furthermore, our results...
The integration of somatosensory information is generally assumed to be a function the central nervous system (CNS). Here we describe fully functional GABAergic communication within rodent peripheral sensory ganglia and show that it can modulate transmission pain-related signals from nerves CNS. We found neurons express major proteins necessary for GABA synthesis release released in response depolarization. In vivo focal infusion or reuptake inhibitor dramatically reduced acute peripherally...
Electrical excitation of peripheral somatosensory nerves is a first step in generation most pain signals mammalian nervous system. Such controlled by an intricate set ion channels that are coordinated to produce degree proportional the strength external stimulation. However, many disease states this coordination disrupted resulting deregulated excitability which, turn, may underpin pathological (i.e. migraine, neuralgia, neuropathic and inflammatory pains). One major groups essential for...
We identified major ion channels influencing the resting membrane potential of nociceptive sensory neurons and demonstrated that changes somatic/perisomatic these can strongly influence peripheral transmission. Peripheral ganglia contain somata afferent fibres conveying somatosensory inputs to central nervous system. Growing evidence suggests region Control (Erest) is an important mechanism regulating excitability, but surprisingly little known about how Erest regulated in neuron or affect...
Accumulating observations suggest that peripheral somatosensory ganglia may regulate nociceptive transmission, yet direct evidence is sparse. Here, in experiments on rats and mice, we show the afferent information undergoes dynamic filtering within dorsal root ganglion (DRG) this occurs at axonal bifurcations (t-junctions). Using synchronous vivo electrophysiological recordings from central processes of sensory neurons (in spinal nerve root), ganglionic transplantation GABAergic progenitor...
Nowadays, the development of wide-bandgap perovskite by thermal evaporation and spin-coating hybrid sequential deposition (HSD) method has special meaning on textured perovskite/silicon tandem solar cells. However, common issues insufficient reaction caused blocking capping layer are exacerbated in HSD, because evaporated precursors usually denser with higher crystallinity widely used additive-assisted microstructure is also difficult to access. Here, a facile "diffusible layer" (DPCL)...
Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying chronic-pain-induced depression behavior. We show development of pain accompanied by depressive-like behaviors mouse model trigeminal neuralgia. In parallel, observe increased activity dopaminergic (DA) neuron midbrain ventral tegmental area (VTA), inhibition this elevated...
Mixed halide wide-bandgap (WBG) perovskites, widely used as a top-cell absorber in tandem solar cells, exhibit severe photoinduced phase segregation. A feasible solution is to exploit pure-iodide WBG essentially increasing Cs content instead of Br achieve bandgap widening. However, the efficiency pure-iodine perovskite cells (PSCs) reported so far has been inferior that typical mixed PSCs due complex nucleation and transition processes, leading poor crystallization quality high density...
Abstract Emerging wearable electronics are spurring unprecedented enthusiasm in the pursuit of next‐generation memory realizable on flexible substrates. Photochromic materials enable reversible manipulation and possess erasable/rewritable capability, which ensure them to be adequate candidates as optical memories. Nevertheless, it has been challenging develop a with organic photochromic elements that simultaneously meets stringent thermo‐ photostable requirements. Inorganic lanthanide Er 3+...
The transmembrane channel-like (TMC) protein family comprises eight members, with TMC1 and TMC2 being extensively studied. This study demonstrates substantial co-expression of TMC7 the mechanosensitive channel Piezo2 in somatosensory neurons. Genetic deletion primary sensory ganglia neurons vivo enhances sensitivity both physiological pathological mechanosensory transduction. leads to an increase proportion rapidly adapting (RA) currents conducted by dorsal root ganglion (DRG) accelerates RA...
Background and Purpose The mesolimbic dopamine system originating in the ventral tegmental area (VTA) is involved development of depression, firing patterns VTA dopaminergic neurons are key determinants this process. Here, we describe a crucial role for M‐type K v 7.4 channels modulating excitability depressive behaviour mice. Experimental Approach We used channel knockout mice social defeat model depression combination with electrophysiological techniques (patch clamp recording vivo...
Abstract In silicon photonics, BaTiO 3 (BTO) emerges as a promising electro‐optic (EO) integrated material due to its excellent EO modulation capabilities. Nevertheless, the response of multi‐domain BTO thin films tends be lower than that bulk materials. are fabricated with strong responses utilizing pulsed laser deposition technique. Considering importance SrTiO (STO) buffer layer, series epitaxial deposited on STO substrates engineered domain alignment. Given contribution variants in their...
Background: Nociceptive responses to noxious stimuli are initiated at peripheral nociceptor terminals. Ion channels play a vital role in pain signal initiation and conduction. Activation of K ATP has been implicated mediating the analgesic effects agents such as morphine. However, systematic studies regarding activators on nociception neuronal excitability scarce. Results: In this study, we describe antagonistic pinacidil diazoxide nocifensive behavior induced by bradykinin (BK), thermo...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the production of granulocyte and macrophage populations from hematopoietic progenitor cells; it is one most common growth factors in blood. GM-CSF also involved bone cancer pain development by regulating tumor-nerve interactions, remodeling peripheral nerves, sensitization damage-sensing (nociceptive) nerves. However, precise mechanism for GM-CSF-dependent unclear. In this study, we found that highly expressed human malignant...
The swelling-activated chloride current ( I Cl,swell ) is induced when a cell swells and plays central role in maintaining volume response to osmotic stress. major contributor of the volume-regulated anion channel (VRAC). Leucine-rich repeat containing 8A (LRRC8A; SWELL1) was recently identified as an essential component VRAC, but mechanisms VRAC activation are still largely unknown; moreover, other Cl − channels, such anoctamin 1 (ANO1), were also suggested contribute . In this present...
Efficient and lossless encapsulation must be resolved before the industrialization of monolithic perovskite/silicon tandem solar cells (PSTs). Here, an ultraviolet (UV) curable material, which is environmentally friendly needs only 1 min UV solidification, designed used to encapsulate three types typical PSTs, namely, flat structure, special texture commercial structure. Since cured encapsulating material has appropriate refractive index similar glass a nondestructive impact on perovskite,...