A5027331434- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Urological Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Biomedical Ethics and Regulation
- Telomeres, Telomerase, and Senescence
- Retinal and Macular Surgery
- Electrospun Nanofibers in Biomedical Applications
Johns Hopkins University
2017-2021
Johns Hopkins Medicine
2017-2019
Medical devices and implants made of synthetic materials can induce an immune-mediated process when implanted in the body called foreign response, which results formation a fibrous capsule around implant. To explore immune stromal connections underpinning we analyzed fibrotic capsules surrounding surgically excised human breast from 12 individuals. We found increased numbers interleukin 17 (IL17)-producing γδ+ T cells CD4+ helper (TH17) as well senescent capsules. Further analysis murine...
The avascular nature of cornea tissue limits its regenerative potential, which may lead to incomplete healing and formation scars when damaged. Here, we applied micro- ultrafine porcine urinary bladder matrix (UBM) particulate promote type 2 immune responses in wounds. Results demonstrated that UBM substantially reduced corneal haze as compared the saline-treated group. Flow cytometry gene expression analysis showed suppressed differentiation stromal cells into α-smooth muscle actin-positive (αSMA
Structural and biochemical cues of extracellular matrix can substantially influence the differentiation maturation cultured retinal pigment epithelial (RPE) cells. In this study, thin collagen vitrigels were engineered to create nanofibrillar structures different fibril densities in an effort evaluate human embryonic stem cell-derived (hESC-RPE) The ultrastructure was characterized by transmission electron microscopy, mechanical properties evaluated tensile testing. pigmentation polarization...
Purpose: To investigate the impact of tissue derived biological particles on enzyme-mediated weakened corneas. Methods: Rabbit corneas were treated with enzymes to create an ex vivo ectatic model that simulated representative characteristics keratoconus (KC). Porcine cornea, cartilage, and lymph node tissues processed remove most cellular components cryomilled into microparticles. The KC cultured in medium containing tissue-derived (TDP) overnight. mechanical, thermal, ultrastructural...