A5075476051- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- RNA modifications and cancer
- Synthesis and Biological Evaluation
- PI3K/AKT/mTOR signaling in cancer
- Phytochemicals and Medicinal Plants
- Cholinesterase and Neurodegenerative Diseases
- Cancer Genomics and Diagnostics
- Diverse Scientific Research Studies
- SARS-CoV-2 and COVID-19 Research
- ATP Synthase and ATPases Research
- Free Radicals and Antioxidants
- Nanoparticles: synthesis and applications
- Metal complexes synthesis and properties
- Medicinal Plant Research
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Cancer Mechanisms and Therapy
- Radiation Shielding Materials Analysis
- Nuclear materials and radiation effects
- Herbal Medicine and Trade Cooperation
JSS Academy of Higher Education and Research
2020-2025
Smith College
2022
JSS Science and Technology University
2020
Amrita Vishwa Vidyapeetham
2020
Davangere University
2020
Institut thématique Génétique, génomique et bioinformatique
2020
T.K.M. College of Arts and Science
2020
National Institute of Technology Warangal
2019
The novel coronavirus pandemic has spread over in 213 countries as of July 2020. Approximately 12 million people have been infected so far according to the reports from World Health Organization (WHO). Preventive measures are being taken globally avoid rapid virus. In current study, an silico approach is carried out a means inhibiting spike protein by flavonoids natural sources that possess both antiviral and anti-inflammatory properties. methodology focused on molecular docking 10 flavonoid...
Abstract Nuclear radiation shielding capabilities for a glass series 20Bi 2 O 3 − xPbO (80 2x)B xGeO (where x = 5, 10, 20, and 30 mol%) have been investigated using the Phy-X/PSD software Monte Carlo N-Particle transport code. The mass attenuation coefficients (μ m ) of selected samples estimated through XCOM dependent program MCNP-5 code in photon-energy range 0.015–15 MeV. So obtained μ values are used to calculate other γ-ray parameters such as half-value layer (HVL), mean-free-path...
Abstract Blood-based approaches to detect early-stage cancer provide an opportunity improve survival rates for lung cancer, the most lethal world-wide. Multiple blood-based detection using molecular analytes derived from individual ‘omics (cell-free DNA, RNA transcripts, proteins, metabolites) have been developed and tested, generally showing significantly lower sensitivity versus late-stage cancer. We hypothesized that approach multiple types of analytes, including broad untargeted coverage...
The increasing interest in developing potent non-toxic drugs medicine is widening the opportunities for studying usage of nanostructures treatment various diseases. present work reports a method facile and an eco-friendly synthesis silver nanoparticles (AgNPs) using Terminalia chebula fruit extract (TCE). obtained AgNPs was characterized by different spectroscopic microscopic techniques. analysis results revealed that as-obtained have spherical morphology with average diameter 22 nm....
Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination, neurodegeneration, and inflammation in the central nervous system. The AXL gene, which codes for receptor tyrosine kinase, has emerged as promising therapeutic target due to its involvement neuroinflammation oligodendrocyte dysfunction. In current study, we employed silico techniques design Antisense Oligonucleotides (ASOs) that selectively gene transcripts modulate expression mitigate MS pathology. Three...
Over the years, Alzheimer's disease (AD) treatments have been a major focus, culminating in identification of promising therapeutic targets. A herbal therapy approach has required by demand AD stage-dependent optimal settings. Present study describes evaluation anti-acetylcholinesterase (AChE) activity hydroxyapatite nanoparticles derived from an Acorus calamus rhizome extract (AC-HAp NPs). The structure and morphology as-prepared NPs) was confirmed using powder X-ray diffractometer (XRD),...
The outbreak of novel coronavirus strain (Covid-19) with a high pandemic threat has predict grave public health and economic concerns. This virus, originating from the Wuhan region in China spread worldwide affecting millions no registered persuasive targeted therapy. In this paper, we analyze three important proteins encoded by envelope protein 5 × 29, RNA binding nucleocapsid 1SSK, spike glycoprotein 6ACD, for an effective virion accumulation, remdesivir was first drug approved FDA EMA...
The spike (S) glycoprotein and nucleocapsid (N) proteins are the crucial pathogenic of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus during its interaction with host. Even FDA-approved drugs like dexamethasone grazoprevir not able to curb viral progression inside host reported adverse effects on body metabolism. In this context, we aim report corilagin a novel, potential dual inhibitor S N from Terminalia chebula. bioactive compounds T. chebula were subjected series...
Researchers are interested in Schiff bases and their metal complexes because they offer a wide range of applications. The chemistry heterocompounds has got lot attention the metal's ability to coordinate with base ligands. In current study, new bidentate ligand,
Introduction Targeted therapy is used to treat lung adenocarcinoma caused by epidermal growth factor receptor (EGFR) mutations in the tyrosine kinase domain and rare subtypes (<5%) of non-small cell cancer. These include fusion oncoproteins like anaplastic lymphoma (ALK), ROS1, rearranged during transfection (RET), other kinases (RTKs). The use diverse selective oral inhibitors, including those targeting rat sarcoma viral oncogene homolog (KRAS) mutations, has significantly improved clinical...
Abstract Background KRAS- mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS -G12C selective inhibitors, leading short median progression-free survival, overall survival. The MET receptor tyrosine kinase (c- ), the cognate of hepatocyte growth factor (HGF), was reported be overexpressed in -mutant cells tumor-growth anchorage-independent conditions. Methods Cell viability assay synergy analysis were carried out native,...
Herein we report the synthesis and structural elucidation of two novel imine-based ligands, 2-(1,10-phenanthrolin-5-yl)imino)methyl)-5-bromophenol (PIB) N-(1,10-phenanthrolin-5-yl)-1-(thiophen-3-yl)methanimine (PTM) ligands. An in vitro cytotoxicity assay synthesized molecules was carried out against breast, cervical, colorectal, prostate cancer cell lines as well immortalized human keratinocytes. The observations indicated that both possesses dose-dependent selective cells with no...
The ever-expanding pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has gained attention as COVID-19 and caused an emergency in public health to unmatched level date. However, the treatments used are only options; currently, no effective licensed medications available combat disease transmission, necessitating further research. In present study, silico-based virtual screening of anti-HIV bioactive compounds from medicinal plants was carried out through...
Introduction: The use of plant extracts in the green synthesis metallic nanoparticles is one simplest, most practical, economical, and ecologically friendly methods for avoiding toxic chemicals. Method: Silver (AgNPs) were synthesized, employing a high-efficiency, non- toxic, cost-effective, green, simple technique that included Salacia oblonga root extract (SOR) as capping agent compared to synthetic nanoparticles. S. can be seen traditional medicines treating diabetes, obesity, rheumatism,...
Bacterial infections are one of the leading causes morbidity, mortality, and healthcare complications in patients. Leptospirosis is found to be most prevalent, re-emergent, neglected tropical zoonotic disease worldwide. The adaptation various environmental conditions has made Leptospira acquire a large genome (~4.6 Mb) complex outer membrane, making it unique among bacteria that mimic symptoms jaundice hemorrhage. Sph2 another important virulence factor enhances hemolytic...
There is a shred of evidence to suggest that Emblica officinalis Gaertn, the botanical name for amla seeds, has greater medicinal potential than fruit. We conducted this work assess anti-inflammatory, antibacterial, and antioxidant capacities E. seed extracts. The bioactive components from seeds were fractionated using chloroform, hexane, methanol, diethyl ether, according polarity solvents. total amount phenolic flavonoid was estimated. Both reducing power extracts evaluated DPPH...