A5004215695- Analytical chemistry methods development
- Forensic Toxicology and Drug Analysis
- Analytical Methods in Pharmaceuticals
- Galectins and Cancer Biology
- 3D Printing in Biomedical Research
- Protein Tyrosine Phosphatases
- Hormonal and reproductive studies
- Surfactants and Colloidal Systems
- Endoplasmic Reticulum Stress and Disease
- Amyotrophic Lateral Sclerosis Research
- Salivary Gland Disorders and Functions
- Radioactive element chemistry and processing
- Microfluidic and Capillary Electrophoresis Applications
- Dental materials and restorations
- Peptidase Inhibition and Analysis
- Opioid Use Disorder Treatment
- Parkinson's Disease Mechanisms and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical Analysis and Applications
- Pesticide Residue Analysis and Safety
- Alzheimer's disease research and treatments
- Poisoning and overdose treatments
- Biosensors and Analytical Detection
- Material Dynamics and Properties
- Electrostatics and Colloid Interactions
University of Bydgoszcz
2020-2025
Nicolaus Copernicus University
2020-2024
Collegium Medicum in Bydgoszcz
2020-2023
BOKU University
2007
This paper proposes an all-in-one microextraction-based protocol capable of determining and quantifying fentanyl, methadone, zolpidem in plasma, urine, saliva at concentrations below those required by international regulatory organizations. A homemade thin-film microextraction device featuring octyl–cyanopropyl stationary phase was coupled with LC-MS/MS. The proposed method developed validated according to FDA criteria, providing extraction efficiency values ranging from 26.7% 76.2% no...
Polyamide noncoated device for adsorption-based microextraction (PANDA microextraction) is a brand new, easy to prepare, environmentally friendly, inexpensive, and efficient sample preparation method created entirely with the use of 3D printing. The proposed based on extractive proprieties unmodified polyamide carbon fiber blends compared highly selective thin-film (TFME). In addition, printing was used simplify process TFME. Prototype devices were evaluated by extraction oral fluid spiked...
This work presents a rational synthesis of 14 innovative methyl salicylate based thiazole (MSBT) derivatives, designed as protein tyrosine phosphatase 1B (PTP1B) inhibitors with potent anticancer activity. Enzyme inhibition studies were performed for all compounds. In addition, molecular docking simulations and assessment antiproliferative activity the most active lot. For studies, cell lines breast cancer (T47D) non-small-cell lung carcinoma (A549), well healthy control human skin...
Selection of a device for oral fluid sample collection has great impact on analysis results.
For identifying and quantifying prohibited substances, solid-phase microextraction (SPME) continues to arouse interest as a sample preparation method. However, the practical implementation of this method in routine laboratory testing is currently hindered by limited number coatings compatible with ubiquitous high-performance liquid chromatography (HPLC) systems. Only octadecyl (C18) polydimethylsiloxane/divinylbenzene ligands are marketed for purpose. To address situation, present study...
Octadecyl (C18) groups are arguably the most popular ligands used for preparation of solid phase microextraction (SPME) devices. However, conventional C18-bonded silica particles not fully compatible with nearly 100% aqueous composition typical biological samples (e.g., plasma, saliva, or urine). This study presents first evaluation thin-film SPME devices coated special water-compatible particles. Device performance was assessed by extracting a mixture 30 model compounds that exhibited...
The adsorption of solutes from a dilute liquid solution is great technical importance but calculations the local density solute and isotherm by standard molecular simulation yield large scattering with increasing dilution. As alternative mean force (MF) method was suggested where MF on constrained molecule integrated over path bulk fluid to wall. It has already been shown that gives reliable results for relative density, even at high Here, an extension this introduced, absolute value...