A5062623666- Hops Chemistry and Applications
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Chromatography in Natural Products
- Fungal Plant Pathogen Control
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Bioactive Compounds and Antitumor Agents
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Bone and Dental Protein Studies
- Seaweed-derived Bioactive Compounds
- vaccines and immunoinformatics approaches
- Ferroptosis and cancer prognosis
- Phytochemical Studies and Bioactivities
- Lipoproteins and Cardiovascular Health
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
Maria Curie-Skłodowska University
2016-2025
Institut Curie
2023
Although betulin (BET), a naturally occurring pentacyclic triterpene, has variety of biological activities, its osteogenic potential not been investigated so far. The aim this study was to assess the effect BET on differentiation human osteoblasts (hFOB 1.19 and Saos-2 cells) in vitro (with ascorbic acid as an supplement) osteoinductive (without additional conditions. Osteoblast evaluated based mRNA expression (RT-qPCR) Runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP),...
Xanthohumol (XN), the main prenylated flavonoid from hop cones, has been recently reported to exert significant proapoptotic, anti-proliferative, and growth inhibitory effects against lung cancer in both vitro vivo studies. However, its anti-metastatic potential towards this malignancy is still unrevealed. Previously, we indicated that human adenocarcinoma A549 cell line was sensitive XN treatment. Therefore, using same tumour model, have studied influence of on...
This work presents a rational synthesis of 14 innovative methyl salicylate based thiazole (MSBT) derivatives, designed as protein tyrosine phosphatase 1B (PTP1B) inhibitors with potent anticancer activity. Enzyme inhibition studies were performed for all compounds. In addition, molecular docking simulations and assessment antiproliferative activity the most active lot. For studies, cell lines breast cancer (T47D) non-small-cell lung carcinoma (A549), well healthy control human skin...
Cyclic sulfones play an important role in the field of drug discovery and design due to their valuable properties broad range applications. Herein, we report efficient cerium(IV)-catalyzed allylic oxidation a simple 3-sulfolene. This process provides straightforward facile approach sulfol-2-en-4-one, versatile synthetic intermediate. Notably, this study represents first instance cerium catalysis employed oxidation. Furthermore, demonstrated transformation sulfol-2-en-4-one into 4-substituted...
Amphotericin B (AmB) is a potent antifungal agent with minimal resistance among clinical isolates, but its use limited by severe side effects. Reducing toxicity through combination therapy synergistic compounds promising strategy. This study investigates the potential of 1,3,4-thiadiazole derivatives, focusing on AT2 and AT10, against Candida species. demonstrated highest activity, achieving complete inhibition at 128 µg/mL notable suppression lower concentrations. The AT10 amphotericin...
Osteosarcoma (OS) is the most common type of primary bone tumor. Currently, there are limited treatment options for metastatic OS. Alpha-ketoglutarate (AKG), i.e., a multifunctional intermediate Krebs cycle, one central metabolic regulators tumor fate and plays an important role in cancerogenesis progression. There growing evidence suggesting that AKG may represent novel adjuvant therapeutic opportunity anti-cancer therapy. The present study was intended to check whether supplementation...
Fourier Transform Infrared spectroscopy was applied to detect in vitro cell death induced prostate (PC-3) and breast (T47D) cancer lines treated with xanthohumol (XN). After incubation of the cells XN, specific spectral shifts infrared spectra arising from selected cellular components were identified that reflected biochemical changes characteristic for apoptosis necrosis. Detailed analysis absorbance intensity ratios revealed compositional secondary structure proteins membrane lipids. In...
In recent years, drug-resistant and multidrug-resistant fungal strains have been more frequently isolated in clinical practice. This phenomenon is responsible for difficulties the treatment of infections. Therefore, development new antifungal drugs an extremely important challenge. Combinations selected 1,3,4-thiadiazole derivatives with amphotericin B showing strong synergic interactions are promising candidates such formulas. study, microbiological, cytochemical, molecular spectroscopy...
Ammi majus L. (Apiaceae) is a medicinal plant with well-documented history in phytotherapy. The aim of the present work was to isolate isopimpinellin (5,8-methoxypsoralen; IsoP) from fruit this and evaluate its biological activity against selected tumor cell lines. methanol extract obtained use an accelerated solvent extraction (ASE) method most suitable for quantitative analysis coumarins A. matrix. coumarin content estimated by RP-HPLC/DAD, amount IsoP found be 404.14 mg/100 g dry wt.,...
4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol (C1) and 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl] benzene1,3-diol (NTBD) are representative derivatives of the thiadiazole group, with a high antimycotic potential minimal toxicity against normal human fibroblast cells. The present study has proved its ability to synergize antifungal activity AmB. aim this work was evaluate cytotoxic effects C1 or NTBD, alone in combination AmB, on renal proximal tubule epithelial cells (RPTECs)...
Background/Aim: Glioma is the most malignant tumour of human brain still lacking effective treatment modalities. Betulin, a pentacyclic triterpene abundantly found in birch bark, has been shown to demonstrate interesting anti-cancer activity towards many cancer cells. We determined effects acetylenic synthetic betulin derivatives (ASBDs) as anti-tumour agents on glioma cells vitro. Materials and Methods: T98G C6 cell viability proliferation were by MTT...
Many organophosphorus compounds (OPs), especially various α-aminophosphonates, exhibit anti-cancer activities. They act, among others, as inhibitors of the proteases implicated in cancerogenesis. Thesetypes weredescribed, e.g., for neutral endopeptidase (NEP) expressed different cancer cells, including osteosarcoma (OS). The aim present study isto evaluate new borane-protected derivatives phosphonous acid (compounds 1–7) terms their drug-likeness properties, anti-osteosarcoma activities...
Here, we rationally designed a human neutrophil elastase (HNE) inhibitors 4a-4f derived from thalidomide. The HNE inhibition assay showed that synthesized compounds 4a, 4b, 4e and 4f demonstrated strong inhibiton properties with IC50 values of 21.78-42.30 nM. Compounds 4c, 4d competitive mode action. most potent compound shows almost the same as sivelestat. molecular docking analysis revealed strongest interactions occur between azetidine-2,4-dione group following three aminoacids: Ser195,...
Gastric cancer is the most common and remains leading cause of death worldwide. In this study, anticancer action magnoflorine isolated via counter-current chromatography from methanolic extract Berberis vulgaris root against gastric in models primary ACC-201 AGS metastatic MKN-74 NCI-N87 cell lines was analyzed. Cell viability proliferation were tested through use MTT BrdU tests, respectively. cycle progression apoptosis evaluated using flow cytometry. The interaction docetaxel has been...
There is some evidence that non-photoactivated psoralens may be active against breast and colon tumor cells. Therefore, we evaluated the antiproliferative, proapoptotic, anti-migrative effect of 5-methoxypsoralen (5-MOP) isolated from Peucedanum tauricum MB fruits in human colorectal adenocarcinoma (HT-29 SW620), osteosarcoma (Saos-2 HOS), multiple myeloma (RPMI8226 U266). Dose- cell-line-dependent effects 5-MOP on viability proliferation were observed, with strongest inhibitory Saos-2 a...