A5010367588- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Adipose Tissue and Metabolism
- Polysaccharides and Plant Cell Walls
- Drug Transport and Resistance Mechanisms
- Hedgehog Signaling Pathway Studies
- Muscle metabolism and nutrition
- Nanoparticle-Based Drug Delivery
- Peroxisome Proliferator-Activated Receptors
- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Cancer, Hypoxia, and Metabolism
- Exercise and Physiological Responses
- Pharmacological Effects of Natural Compounds
- Fungal Biology and Applications
- Nuts composition and effects
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- Tea Polyphenols and Effects
- Immune Response and Inflammation
- Phytoestrogen effects and research
- Phytochemistry and Bioactive Compounds
- Ginger and Zingiberaceae research
- Facial Rejuvenation and Surgery Techniques
- Biocrusts and Microbial Ecology
Gangneung–Wonju National University
2021-2025
Heilongjiang Bayi Agricultural University
2022-2025
Shanghai University of Traditional Chinese Medicine
2012-2023
Lapatinib is used for the treatment of metastatic HER2(+) breast cancer. We aim to establish a prediction model lapatinib dose using machine learning and deep techniques based on real-world study. There were 149 cancer patients enrolled from July 2016 June 2017 at Fudan University Shanghai Cancer Center. The sequential forward selection algorithm random forest was applied variable selection. Twelve algorithms compared in terms their predictive abilities (logistic regression, SVM, forest,...
Resveratrol (Res), 3,5,4'-trihydroxy-trans-stilbene, is an antioxidant found in the skin of red grapes and several other plants. This phenolic compound has been recently reported to possess cancer chemopreventive activity that inhibits process carcinogenesis. However, mechanisms underlying its anticancer effects remain largely unresolved. In this study, we investigated chemoprotective dietary Res azoxymethane (AOM) induced precancerous colorectal lesion model male Wistar rats. The metabolic...
The brainstem, the core of central nervous system, plays a vital role in controlling arterial blood pressure and its elevation hypertension subtypes, especially essential hypertension. Integrative metabolic proteomic profiling was performed on brainstem samples 11 week old spontaneously hypertensive rats (SHRs) age-matched normotensive Wistar rats, using hydrophilic interaction liquid chromatography quadrupole/time-of-flight mass spectrometry (HILIC-Q/TOFMS) (PeptideAtlas: PASS01621)...
Hypertrophic scars (HSs) develop due to excessive collagen deposition and abnormal fibroblast proliferation during wound healing, significantly impacting patient quality of life. Three dosages GA ointments were administered rabbit ear HS models investigate the potential efficacy mechanism gallic acid (GA) on HS. Daily application ointment was performed matrix group, groups, silicone gel group for 28 days. (No drug treatment skin model groups as a blank vehicle topically positive control...
Inflammatory activation and intestinal flora imbalance play key roles in the development progression of inflammatory bowel disease (IBD). Soluble dietary fiber (SDF) selenium have been proven to be effective for preventing relieving IBD. This study investigated compared therapeutic efficacy millet-derived selenylated-soluble (Se-SDF) against dextran sulfate sodium (DSS)-induced colitis mice alone or through synergistic interaction between SDF. In female mice, Se-SDF markedly alleviated body...
Melatonin can directly or indirectly eliminate reactive oxygen species, regulate hormone levels, and improve drought-stressed soybean crop resistance, yield, quality. The nutrient contents of soybeans grown under normal conditions (WW), drought stress (D), with exogenous melatonin (D + M) ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>p</mi> <mo><</mo> <mn>0.05</mn> </math> ) were compared. differences in the quality natto from three groups also analyzed. results showed...
Limited investigations on metabolic responses to exercise training in female adolescent volleyball athletes exist. The aim of this study was obtain serum and urine metabolite markers within 2-week strength-endurance using a metabolomics approach coupled with biochemical analysis, which would be potential biomarkers for evaluating the physiological state athletes.Twelve were recruited training. Differential profiles between pre- post-training group obtained gas chromatography mass...
Veratramine, a steroidal alkaloid originating from Veratrum nigrum L., has demonstrated distinct anti-tumor and anti-hypertension effects, however, its metabolism rarely been explored. The objective of the current study was to provide comprehensive investigation metabolic pathways. in vitro profiles veratramine were evaluated by incubating it with liver microsomes cytosols. vivo plasma, bile, urine feces monitored UPLC-MS/MS after oral (20 mg/kg) i.v. (50 µg/kg) administration rats....
Triple-negative breast cancer (TNBC) is well-known for its metastatic aggressiveness and poor survival prognosis, accounting nearly a quarter of cases in cancer. We performed intra- extra-cellular profiling 40 amino acids derivatives on three cell lines their culture media, including TNBC, non-TNBC normal epithelial cells, using HILIC-MS/MS. Characteristic metabolic alteration was observed TNBC compared to especially correlated pathways. Intra-cellularly, quantified glutamic acid, β-alanine,...
To improve the utilization of soluble dietary fiber (SDF) from tiger nut residues, response surface methodology was used to optimize conditions superfine grinding produce SDF with antioxidant and metal-ion-binding properties. The yield increased (30.56%) average particle diameter decreased (D50: 32.80 μm) under optimal (a proportion medium 100%, a feeding mass 0.90 kg, time 20 min, moisture content 8.00%). In addition, substantially modified morphology monosaccharides by decreasing molecular...