A5060481707- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Acute Lymphoblastic Leukemia research
- Electronic Health Records Systems
- Lymphoma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Genomic variations and chromosomal abnormalities
- Biomedical Text Mining and Ontologies
- Ethics in Clinical Research
- Blood transfusion and management
- Erythropoietin and Anemia Treatment
- Genomics and Rare Diseases
- Digital Imaging for Blood Diseases
- Hemoglobin structure and function
- Fungal Infections and Studies
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Malaria Research and Control
- AI in cancer detection
- Retinoids in leukemia and cellular processes
- Mosquito-borne diseases and control
- Hemophilia Treatment and Research
- Artificial Intelligence in Healthcare
The University of Texas Southwestern Medical Center
2016-2025
Medical City Children's Hospital
2015-2025
Southwestern Medical Center
2014-2024
Children's Medical Center
2012-2024
Propath Services (United States)
2019
University of Nebraska Medical Center
2019
New York University
2019
Mayo Clinic
2019
Yale University
2019
Children's Healthcare of Atlanta
2019
Blood diseases and disorders, including leukemia infectious of red blood cells, pose significant diagnostic challenges due to their complex presentations reliance on time-consuming cytomorphological analysis detect subtle morphologic features. While microscopic examination remains the gold standard in diagnosis, its dependence expert interpretation highlights need for advanced methods enhance workflow. Recently, deep learning (DL) have shown promise medical imaging by automating improving...
ABSTRACT Objectives Mixed phenotype acute leukemia ( MPAL ) often poses challenges in diagnosis and clinical management. This is the first study to assess lineage/immunophenotype‐genotype association significance of AML ‐myelodysplasia‐related changes MR , cytogenetic abnormalities gene mutations, ‐ CG ‐Gene) classification. Methods We conducted a clinicopathologic genomic evaluation 25 cases by WHO HEM5 / ICC classification criteria, except for retaining those with ‐Gene Conditional )....
Tau aggregation underlies neurodegeneration in Alzheimer's disease and related tauopathies. We others have proposed that transcellular propagation of pathology is mediated by prions, which are ordered protein assemblies faithfully replicate vivo cause specific biological effects. The prion model predicts the release aggregates from a first-order cell subsequent uptake into second-order cell. then serve as templates for their own replication, process termed "seeding." previously observed...
Postauthorization safety surveillance of factor VIII (FVIII) concentrates is essential for assessing rare adverse event incidence. We determined and efficacy ADVATE [antihaemophilic (recombinant), plasma/albumin-free method, (rAHF-PFM)] during routine clinical practice. Subjects with differing haemophilia A severities medical histories were monitored 12 months prophylactic and/or on-demand therapy. Among 408 evaluable subjects, 386 (95%) received excellent/good ratings all assessments; the...
Conventional microscopy is the gold standard for malaria diagnosis. The CellaVision DM96 a digital hematology analyzer that utilizes neural networks to locate, digitize, and preclassify leukocytes characterize red blood cell morphology. This study compared detection rates of Plasmodium Babesia species on peripheral smears utilizing with routine morphology scan. A total 281 slides were analyzed, consisting 130 positive or 151 negative controls. Slides blinded, randomized, analyzed by scans....
To implement Lean principles to accommodate expanding volumes of gastrointestinal biopsies and improve laboratory processes overall.Our continuous improvement (kaizen) project analyzed the current state for biopsy handling using value-stream mapping specimens obtained at a 487-bed tertiary care pediatric hospital in Dallas, Texas. We identified non-value-added time within workflow process, from receipt specimen histology delivery slides paperwork pathologist. eliminate steps, we implemented...
Biomedical terminologies such as Logical Observation Identifiers, Names, and Codes (LOINC) were developed to enable interoperability of health care data between disparate information systems improve patient outcomes, public health, research activities.To ascertain the utilization rate accuracy LOINC terminology mapping 10 commonly ordered tests by participants College American Pathologists (CAP) Proficiency Testing program.Questionnaires sent 1916 US Canadian laboratories participating in...
Abstract In non-endemic settings, transfusion-transmitted malaria (TTM) is rare but potentially fatal and becoming more common with globalization. We present two pediatric cases that demonstrate donor screening using questionnaires subject to error TTM should be considered fever following numerous transfusions in children, particularly sickle cell patients.
Abstract Introduction Myeloperoxidase (MPO) is considered a specific marker of myeloid/non‐monocytic lineage in the diagnosis mixed phenotype acute leukemia (MPAL). However, clinical significance isolated dim MPO expression otherwise typical B lymphoblastic (B‐ALL; referred to as B/myeloid MPAL isoMPO ) adult patients unknown. Methods We compared flow cytometric immunophenotype and clinicopathological findings among cases ( n = 13), other subtypes 10, T/myeloid MPAL), B‐ALL 64), myeloid...
Abstract Objective The objective was to identify information loss that could affect clinical care in laboratory data transmission between 2 health institutions via a Health Information Exchange platform. Materials and Methods Data results of 9 tests, including LOINC codes, were compared the following: sending receiving electronic record (EHR) systems, individual Level Seven International (HL7) Version messages across instrument, system, EHR. Results Loss for similar tests indicated following...
Abstract Objectives Automated cell counters have replaced manual enumeration of cells in blood and most body fluids. However, due to the unreliability automated methods at very low counts, laboratories continue perform labor‐intensive counts on many or all cerebrospinal fluid ( CSF ) samples. This multicenter clinical trial investigated if GloCyte System (Advanced Instruments, Norwood, MA ), a recently FDA ‐approved counter, which concentrates enumerates red RBC s) total nucleated TNC s), is...
Abstract Background and Objectives Providing red blood cell (RBC) transfusion to paediatric patients with a haemoglobin (Hb) level of <7 g/dL is the current best practice, but it often difficult ensure appropriateness RBC on health system level. Electronic record (EHR) clinical decision support systems have been shown be effective in encouraging providers transfuse at appropriate Hb thresholds. We present our experience an interruptive practice alert (BPA) healthcare system. Materials...
Diagnosis of high-grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements (double-/triple-hit [DTHL]) appears to mandate fluorescence in situ hybridization (FISH) testing for all large (LBCL). Given the low incidence DTHL, we aimed identify flow cytometry (FC) immunohistochemistry (IHC) features DTHL that could be used develop an optimal screening strategy. This combined FC-IHC approach has not yet been studied.We compared 40 cases 39 diffuse LBCL (DLBCL) without rearrangement.Bright...
Context.—Hemoglobin (Hb) Austin was defined in 1977, using amino acid sequencing of samples from 3 unrelated Mexican-Americans, as a substitution serine for arginine at position 40 the β-globin chain (Arg40Ser). Its electrophoretic migration on both cellulose acetate (pH 8.4) and citrate agar 6.2) reported between Hb F A, this description persists reference literature. Objectives.—To review clinical features redefine diagnostic characteristics Austin. Design.—Eight 6 individuals 2 siblings,...