A5062118049- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
Italian Institute of Technology
2022-2024
The induction of synaptic plasticity at an individual dendritic glutamatergic spine can affect neighboring spines. This local modulation generates microdomains believed to expand the neuronal computational capacity. Here, we investigate whether also occur between synapses and adjacent GABAergic synapses. We find that long-term potentiation causes depression nearby inhibitory (within 3 μm), whereas more distant ones are potentiated. Notably, L-type calcium channels calpain required for this...
Pyramidal neurons (PNs) receive and integrate thousands of synaptic inputs impinging onto their dendritic arbor to shape the neuronal output. The richness complexity such input-output transformation primarily relies on ability generate different forms local spikes, regenerative events originating in dendrites profoundly influencing probability temporal structure somatic spiking. Extensive work during last two decades has identified impact clustering cooperative plasticity among glutamatergic...