A5034636147- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Monoclonal and Polyclonal Antibodies Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- BRCA gene mutations in cancer
- Esophageal Cancer Research and Treatment
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Fungal Infections and Studies
- Multiple and Secondary Primary Cancers
- Neuroendocrine Tumor Research Advances
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Women's cancer prevention and management
- Ovarian cancer diagnosis and treatment
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
Instituto Nacional de Cancerología
2023-2024
Pontificia Universidad Javeriana
2023
Hospital Universitario San Ignacio
2018
Abstract Triple negative breast cancer (TNBC) is highly immunogenic and high levels of tumor infiltrating lymphocytes (TILs) have been associated with a better prognosis higher probability to achieve pathological complete response. Here, we explore the potential role stromal TILs level composition as prognostic predictive biomarker in TNBC. 195 Tumor biospecimens from patients diagnosed TNBC were included. Stromal (sTILs), positive CD4/CD8 cells evaluated. Differences clinic-pathological...
Objective To describe the survival outcomes of metastatic non-small cell lung cancer patients with limited access to immunotherapy and targeted therapy in a reference center Colombia. Methods A retrospective analysis treated between 2013 2018 was performed, majority diagnosed adenocarcinoma. It carried out public that provides care low middle socioeconomic status. Overall progression-free were evaluated by Kaplan–Meier log-rank test. Cox regression model performed for univariate multivariate...
HER2-low tumors have shown promise in response to antibody-drug conjugates (ADCs) recent clinical trials, underscoring the need characterize this group's phenotype. In study, we aimed explore clinicopathological features, survival rates, and HER2 amplicon mRNA expression of women affected with breast cancer, compared HER2-negative HER2-positive groups. We included 516 cancer patients from Colombia, for whom three genes (
402 Background: Gastric cancer (GC) is the leading cause of cancer-related deaths in Colombia, GLOBOCAN estimated 6.451 2022. Development immune checkpoint inhibitors and HER2 target therapy with chemotherapy had improved overall survival advanced setting, but we do not have data about prevalence biomarkers used for selection these patients Colombia or Latin-America. Our aim to describe currently treatment a real-world multicenter cohort gastric gastroesophageal junction (GEJ) cancer....
<title>Abstract</title> Objective This study aims to broaden the understanding of <italic>BRCA1</italic>-associated Hereditary Breast and Ovarian Cancer (HBOC) syndrome by highlighting its link non-traditional cancer types such as gastric salivary gland tumors in a Colombian family. Case Presentation: We present case 61-year-old woman with mucoepidermoid carcinoma who underwent significant surgical treatment. The family history revealed diverse pattern, including gastric, breast, colorectal...
Abstract Introduction: Triple negative breast cancer (TNBC), occurs in 10%-20% of all and presents a higher frequency Latinas compared to non-Hispanic white women. It is highly immunogenic high levels tumor infiltrating lymphocytes (TILs) have been associated with better overall survival probability achieve pathological complete response (pCR). Objective: This the first study Colombian women aimed explore stromal TILs (sTILs) level composition as prognostic predictive biomarker TNBC....
Objective: This study aimed to describe the principal clinical features, survival outcomes, and prognostic factors of patients with small cell lung cancer (SCLC) treated at Instituto Nacional de Cancerologia (INC) between 2013 2018.
El cáncer de mama es la neoplasia más frecuente y mayor mortalidad en las mujeres todo el mundo. receptor 2 del factor crecimiento epidérmico humano (HER2) se sobreexpresa aproximadamente 20% pacientes con asocia a riesgo recidiva tumoral mortalidad. Antes desarrollo los anticuerpos monoclonales dirigidos contra HER2, HER2 positivo estaba asociado un pronóstico desfavorable. uso terapias dirigidas anti ha mejorado significativamente tasas supervivencia global tanto escenario adyuvante como...
La adición de la terapia dirigida a quimioterapia citotóxica en pacientes con cáncer mama ha mejorado significativamente los desenlaces oncológicos las tumores HER2 positivo. El uso pertuzumab durante el manejo neoadyuvante incrementa respuesta patológica completa y actualidad permite emplear regímenes libres antraciclinas una eficacia similar menores efectos cardiovasculares (en especial sobre fracción eyección). beneficio supervivencia libre enfermedad invasiva, adicionar escenario...
Objetivos: el objetivo de este estudio fue describir las características clínicas, los resultados supervivencia y factores asociados con pronóstico pacientes cáncer pulmón célula pequeña (CPCP) manejados en Instituto Nacional Cancerología (INC) entre 2013 2018