A5091586686- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Vaccine Coverage and Hesitancy
- Genomics and Rare Diseases
- Ethics in Clinical Research
- Biotechnology and Related Fields
- Biomedical Ethics and Regulation
- Biomedical and Engineering Education
- Art Therapy and Mental Health
- Intellectual Property and Patents
- Health, psychology, and well-being
- COVID-19 Impact on Reproduction
- Influenza Virus Research Studies
- Science, Research, and Medicine
- Viral gastroenteritis research and epidemiology
- Pharmaceutical Economics and Policy
- Delphi Technique in Research
- Virology and Viral Diseases
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genetically Modified Organisms Research
- Venous Thromboembolism Diagnosis and Management
- Innovation Policy and R&D
- Obesity and Health Practices
Ministero della Salute
2023-2024
Sapienza University of Rome
2014-2023
Azienda Sanitaria Locale Roma 3
2021
Centre for Sustainable Healthcare
2017
Introduction Genomics holds significant promise for prevention and clinical care yet integrating it into the national healthcare system (NHS) requires considerable system-wide changes. This study assessed current stage of Italy in use genomics, to map critical areas improvement contribute a strategic plan. Methods A total 18 experts rated individually level maturity Italian NHS on scale from 1 (lowest) 5 (highest) using B1MG Maturity Level Model tool. instrument is an European matrix 49...
Background The existing frameworks for the evaluation of genetic and genomic applications clearly address technical clinical value a test, but are less concerned with way services delivered organized. We therefore aimed to develop comprehensive new framework that includes an assessment service delivery. Methods A was built on dimensions identified through systematic review Delphi survey Italian experts in public health genomics. Results Our has four sections. first two sections,...
In response to the decline in child vaccination coverage and subsequent occurrence of large vaccine-preventable disease outbreaks, 2017 Italy introduced a new law that made ten vaccines mandatory for children aged 0-16 years. The policy change initiated an ongoing debate among general public, as well political arena scientific community, over this major public health concern. Hence, we conducted survey aimed at assessing Italian professionals' attitudes towards opinions on vaccination. A...
Public health genomics (PHG) aims to integrate advances in genomic sciences into healthcare for the benefit of general population. As many countries, there are various research initiatives this field Italy, but a clear picture national portfolio has never been sketched. Thus, we aimed provide an overview current PHG projects at or international level by consultation with Italian institutional and academic experts. We included 68 projects: majority were which researchers participated ( n =...
We evaluated whether genetic tests with evidence of clinical and personal utility (i.e. APC BRCA1/2 tests) are associated higher satisfaction a more positive perception care experience than those undefined for thrombophilia). A cross-sectional survey was performed through telephone interviews to patients tested deleterious variants in or genes, inherited thrombophilia (FV Leiden and/or FIIG20210A) during 5-year period (2008-2012). Three aspects patient were assessed: effective communication...
Background The international public health (PH) community is debating the opportunity to incorporate genomic technologies into PH practice. A survey was conducted assess attitudes of European Public Health Association (EUPHA) members towards their role in implementation genomics (PHG), and knowledge genetic testing delivery services. Methods EUPHA were invited via monthly newsletter e-mail take part an online from February 2017 January 2018. descriptive analysis conducted, along with a...
Background: During the past decade a debate has arisen on possible utility of genomic science for public health purposes. Within this context, survey is being conducted to assess attitudes European (PH) professionals belonging EUPHA network regarding their role in implementation genomics (PHG), and knowledge genetic testing delivery services.
 Methods: A pilot on-line was from Sapienza University Rome Vrije Amsterdam. The tool composed 5 sections: Personal details, Professional...
Abstract Background Genomic screening has unique challenges which makes it difficult to easily implement on a wide scale. If the costs, benefits and tradeoffs of investing in genomic are not evaluated properly, there is risk wasting finite healthcare resources also causing avoidable harm. Main text professionals – including policy makers, payers providers wish incorporate into while minimizing waste, maximizing benefits, considering results that matter patients, using principles triple value...
Introduction Assessment of the risks and benefits genetic genomic tests has long been addressed using ad hoc evaluation methods. They are mostly ACCE-based, focus on technical aspects, often overlook economic organizational considerations. The few health technology assessment (HTA) based approaches, though more comprehensive, lack validation implementation. This review’s purpose was to identify frameworks for synthesize their key aspects. Methods PubMed, Scopus, Web Science, Google Scholar,...
Introduction Frameworks based on the ACCE model, which have a limited health technology assessment (HTA) approach, long been used in of genetic and genomic applications (GGAs). While frameworks are mainly focused technical aspects, HTA assessments include economic organizational aspects. The aim this study was to develop framework able address comprehensive GGAs. Methods We analyzed most currently model Europe, EUnetHTA Core Model®, investigate its suitability as an for GGAs identify any...