A5064689168- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Cholesterol and Lipid Metabolism
- Cerebral Palsy and Movement Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- interferon and immune responses
- Vasculitis and related conditions
- Transplantation: Methods and Outcomes
- Advanced Radiotherapy Techniques
- Otitis Media and Relapsing Polychondritis
- Estrogen and related hormone effects
- Bipolar Disorder and Treatment
- Liver Disease and Transplantation
- Advances in Oncology and Radiotherapy
- Urticaria and Related Conditions
- History of Medical Practice
- Dermatology and Skin Diseases
- Organ Transplantation Techniques and Outcomes
- Bone Metabolism and Diseases
- Anatomy and Medical Technology
- Medication Adherence and Compliance
Western University
2014-2024
St Joseph's Health Care
2022-2024
Dalhousie University
2019-2021
Izaak Walton Killam Health Centre
2021
Queen Elizabeth II Health Sciences Centre
2020
Children’s Health Research Institute
2014
University of Virginia
2012
Joint homeostasis failure can result in osteoarthritis (OA). Currently, there are no treatments to alter disease progression OA, but targeting early changes cellular behavior has great potential. Recent data show that nuclear receptors contribute the pathogenesis of OA and could be viable therapeutic targets, their molecular mechanisms cartilage incompletely understood. This study examines global gene expression after treatment with agonists for four receptor implicated (LXR, PPARδ, PPARγ,...
Male rats transgenic for HLA-B27 and human β(2) -microglobulin (hβ(2) m) spontaneously develop epididymoorchitis (EO) preceding the development of spondylarthritis (SpA). In specific B27/hβ(2) m-transgenic rat cross-strain (21-3 × 382-2)F(1) , only males SpA, neither sex develops gut inflammation. This study was undertaken to determine whether EO SpA in male are causally related. addition, primary characteristics this arthritis model were assessed.Male underwent bilateral, unilateral, or...
Early-onset scoliosis (EOS) is common in children with cerebral palsy (CP). The effectiveness of magnetically controlled growing rods (MCGR) and the risk for unplanned return to operating room (UPROR) remain be studied this patient population. primary outcome study was examine frequency UPROR between MCGRs as compared traditional growth friendly (TGF) surgeries EOS secondary CP.Patients CP were prospectively identified from an international database, data retrospectively analyzed. Scoliosis,...
Osteoarthritis (OA) is the most common type of arthritis and causes debilitating symptoms decreased quality life. A better understanding molecular mechanisms maintaining cartilage health needed for developing novel therapeutic strategies. Liver X Receptors (LXRs) are nuclear receptors that have been previously shown to protect against OA. To understand regulatory behind this effect, we systematically examined LXR's effects on growth plate chondrocyte gene expression.Primary chondrocytes...
The genetic and developmental mechanisms involved in limb formation are relatively well documented, but how these modulated by changes chondrocyte physiology to produce differences bone length remains unclear. Here, we used high throughput RNA sequencing (RNAseq) probe the basis of variation Longshanks, a mouse model experimental evolution. We find that increased tibia Longshanks is associated with altered expression few key endochondral ossification genes such as Npr3, Dlk1, Sox9, Sfrp1,...
The 2018 Annual General Meeting (AGM) and Young Investigators’ Forum (YIF) of the Canadian Society Clinician Investigators (CSCI) Investigator Trainee Association Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was held in Toronto, Ontario on November 19–20, 2018, conjunction with University of
 Toronto Program Research Day. theme for meeting “Prepare Success—Things to Master Now Scientists Training”; lectures workshops that were designed provide...
Background As Radiation Oncology (RO) is a field with limited exposure in undergraduate medical education curricula, the information sources used to form students' perception of can have substantial impact on whether students decide pursue experiences RO. Furthermore, effects single elective experience RO strongly influence career decisions as it may serve only for gain an understanding specialty. This study analyzes which use and most value when forming their both before after participating...
Rheumatoid arthritis is a chronic inflammatory condition that can significantly affect patients and society at large due to decreased quality of life, direct indirect costs subsequent socioeconomic burden. Medication adherence plays big role in optimal disease management, as higher associated with lower activity. We examine the differences between intentional non-intentional non-adherence suggest potential solutions on how integrate this understanding into clinical practice improve...
Abstract Objective Osteoarthritis (OA) is the most common type of arthritis and causes debilitating symptoms decreased quality life. Currently available treatment options target but do not address underlying issue joint tissue degeneration. As such, a better understanding molecular mechanisms maintaining cartilage health needed for developing novel therapeutic strategies. Liver X Receptors (LXRs) are nuclear receptors that have been previously shown to offer protection against OA. This...
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