A5072163257- Nerve Injury and Rehabilitation
- Shoulder and Clavicle Injuries
- Patient Safety and Medication Errors
- Shoulder Injury and Treatment
- Cardiac Structural Anomalies and Repair
- Spinal Fractures and Fixation Techniques
- Peripheral Nerve Disorders
- Spine and Intervertebral Disc Pathology
- Trauma Management and Diagnosis
- Probiotics and Fermented Foods
- Spatial Cognition and Navigation
- Nerve injury and regeneration
- Orthopedic Surgery and Rehabilitation
- Diversity and Career in Medicine
- Viral gastroenteritis research and epidemiology
- Diabetes Management and Research
- Cervical and Thoracic Myelopathy
- Education and Technology Integration
- Knee injuries and reconstruction techniques
- Categorization, perception, and language
- Pain Mechanisms and Treatments
- Hospital Admissions and Outcomes
- Respiratory Support and Mechanisms
- Sports injuries and prevention
- Cardiovascular Issues in Pregnancy
University College London
2012-2024
Royal National Orthopaedic Hospital
2012-2024
George Washington University
2023
NGM Biopharmaceuticals (United States)
2021-2022
Western University of Health Sciences
2021
Cleveland State University
2018-2019
Hammersmith Hospital
1980-2018
Imperial College London
2015-2018
Children's Hospital of Pittsburgh
2018
Mount Allison University
2007-2015
Background Biomechanical studies comparing various surgical techniques for acromioclavicular joint reconstruction have reported that semitendinosus tendon graft coracoclavicular ligament provides a substantial improvement in initial stability and load-to-failure equivalent to the intact ligaments. Although it represents biomechanical compared with coracoacromial transfer, there is still lack of prospective comparative confirming clinical relevance these findings. Hypothesis Semitendinosus...
Objective To estimate the efficacy of a probiotic yogurt compared to pasteurised for prevention antibiotic-associated diarrhoea in children. Design and setting This was multisite, randomised, double-blind, placebo-controlled clinical trial conducted between September 2009 2012. The study through general practices pharmacies Launceston, Tasmania, Australia. Participants interventions Children (aged 1–12 years) prescribed antibiotics, were randomised receive 200 g/day either (probiotic)...
Background The clinical efficacy of the Angiotensin II (AngII) receptor AT 2 R antagonist EMA401, a novel peripherallyrestricted analgesic, was reported recently in post-herpetic neuralgia. While previous studies have shown that is expressed by nociceptors human DRG (hDRG), and EMA401 inhibits capsaicin responses cultured hDRG neurons, expression levels its endogenous ligands AngII AngIII neuropathic pain tissues, their signalling pathways, require investigation. We immunostained AngII,...
PURPOSE. To evaluate the diagnostic value of magnetic resonance imaging (MRI) in thoracic outlet syndrome (TOS). METHODS. Medical records 30 women and 10 men aged 18 to 68 (mean, 38) years who presented with unilateral (n=35) bilateral (n=5) TOS underwent 42 surgical decompressions right (n=23) left (n=19) sides were reviewed. MRI findings compared intra-operative MRI. RESULTS. correlated poorly findings. Of cases, matched 17 not 25. appeared normal but fact positive for 23 24 cases. The...
Type 1 diabetes mellitus (T1D) is a chronic disease with potentially severe complications, and β-cell deficiency underlies this disease. Despite active research, no therapy to date has been able induce regeneration in humans. Here, we discover the regenerative effects of glucagon receptor antibody (anti-GcgR). Treatment anti-GcgR mouse models leads reversal hyperglycemia, increase plasma insulin levels, restoration mass. We demonstrate that both proliferation α- transdifferentiation...
Abstract We present the results of a double-blind trial naftidrofuryl (Praxilene) in treatment intermittent claudication. One hundred and twenty-eight patients were subjected to standard walking test 3 6 months after treatment. There was no significant objective improvement attributable drug. Although both groups significantly increased their time onset pain, those over 60 years old taking showed pretreatment times whereas controls did not.
Abstract Introduction: Granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is highly expressed in peripheral macrophages and microglia, involved arthritis cancer pain animal models. However, there limited information on GM-CSFR expression human central nervous system (CNS), nerves, or dorsal root ganglia (DRG), particularly chronic conditions. Objectives: Immunohistochemistry was used to quantify levels tissues, functional sensory effects of GM-CSF were studied cultured DRG...
We present our experience of managing patients with iatropathic brachial plexus injury after delayed fixation a fracture the clavicle. It is retrospective cohort study treated at peripheral nerve unit and single illustrative case report. identified 21 in whom occurred as direct consequence clavicle between September 2000 2011. The predominant involved C5/C6 nerves, upper trunk, lateral cord suprascapular nerve. In all patients, injured was found to be tethered under surface by scar tissue...
An expert opinion study was designed to query five countries and six brachial plexus surgeons regarding the demographics, mechanisms of injury, evaluation, timing surgery, reconstructive strategies controversies in adult traumatic pan injuries. Variations assessing outcomes, management neuropathic pain future considerations were elucidated. Clear differences regional patient evaluation treatment identified. The role phrenic nerve contralateral C7 transfer, acute use free functioning muscle...
We reviewed 42 consecutive children with a supination deformity of the forearm complicating severe birth lesions brachial plexus. The overall incidence over study period was 6.9% (48 696). It absent in those Narakas group I (27.6) and occurred 5.7% II (13 229), 9.6% III (11 114) 23.4% IV (18 77). Concurrent deformities at shoulder, elbow, wrist hand were always present because muscular imbalance from poor recovery C5 C7, inconsistent C8 T1 good C6. Early surgical correction improved function...
Abstract The nociceptin/orphanin FQ peptide receptor (NOP), activated by its endogenous ligand (N/OFQ), exerts several effects including modulation of pain signalling. We have examined, for the first time, tissue distribution NOP in clinical visceral and somatic disorders immunohistochemistry assessed functional μ-opioid activation cultured human rat dorsal root ganglion (DRG) neurons. Quantification NOP-positive nerve fibres within bladder suburothelium revealed a remarkable several-fold...
We describe the early results of glenoplasty as part technique operative reduction posterior dislocation shoulder in 29 children with obstetric brachial plexus palsy. The mean age at operation was five years (1 to 18) and they were followed up for a 34 months (12 67). Mallet score increased from 8 (5 13) 12 (8 15) final follow-up (p < 0.001). passive forward flexion by 18° = 0.017) abduction 24° lateral rotation also 54° 0.001), but medial reduced only 7°. One patient required two further...
We investigated the predictive value of intra-operative neurophysiological investigations in obstetric brachial plexus injuries. Between January 2005 and June 2011 a total 32 infants 206 referred to our unit underwent exploration plexus, including neurolysis. The findings from electromyography, sensory evoked potentials across lesion gross muscular response stimulation were evaluated. A 22 neurolysis alone ten had microsurgical reconstruction. Of former, one was lost follow-up, glenoplasty...