A5041189642- Sphingolipid Metabolism and Signaling
- Nerve Injury and Rehabilitation
- Orthopedic Surgery and Rehabilitation
- Gastric Cancer Management and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Microtubule and mitosis dynamics
- Lipid Membrane Structure and Behavior
- Vascular Tumors and Angiosarcomas
- Shoulder and Clavicle Injuries
- Erythrocyte Function and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Fiber Laser Technologies
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Alzheimer's disease research and treatments
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- Dupuytren's Contracture and Treatments
- Inflammasome and immune disorders
- Cancer Treatment and Pharmacology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Elbow and Forearm Trauma Treatment
- Dementia and Cognitive Impairment Research
- Tuberous Sclerosis Complex Research
- Reconstructive Surgery and Microvascular Techniques
National University of Singapore
2011-2024
National University Health System
2024
Singapore General Hospital
2009-2011
University College London
2009
Royal National Orthopaedic Hospital
2009
Nerve Centre
2009
National University Hospital
2000
Abstract Microglial cells are resident macrophages of the central nervous system (CNS) that respond to bioactive lipids such as docosahexaenoic acid (DHA). Low micromolar concentrations DHA typically promote anti-inflammatory functions microglia, but higher result in a form pro-inflammatory programmed cell death known pyroptosis. This study used scanning electron microscopy (SEM) and transmission (TEM) investigate morphological characteristics pyroptosis BV-2 microglial following exposure...
While elevated blood glial fibrillary acidic protein (GFAP) has been associated with brain amyloid pathology, whether this association occurs in populations high cerebral small vessel disease (CSVD) concomitance remains unclear.
Abstract Background Emergency gastric resection for complicated peptic ulcer and cancer is a major challenge general surgeons. This study aimed to evaluate the results of emergency gastrectomy examine factors that predict operative outcome. Methods A total 82 consecutive patients who underwent were studied. The following variables assessed: pathology, mortality rate, morbidity, reasons reoperation related Results There 64 men 18 women with median age 62 (range 30–90) years. indications...
Ototoxicity is a major adverse effect of platinum-based chemotherapeutics and currently, there remains lack United States Food Drug Administration-approved therapies to prevent or treat this problem. In our study, we examined the role sphingosine 1-phosphate receptor 2 (S1P2) in attenuating cisplatin-induced ototoxicity several different animal models cell lines. We found that S1P2 knockout mice dependent on reactive oxygen species (ROS) production activation with specific agonist, CYM-5478,...
We reviewed 42 consecutive children with a supination deformity of the forearm complicating severe birth lesions brachial plexus. The overall incidence over study period was 6.9% (48 696). It absent in those Narakas group I (27.6) and occurred 5.7% II (13 229), 9.6% III (11 114) 23.4% IV (18 77). Concurrent deformities at shoulder, elbow, wrist hand were always present because muscular imbalance from poor recovery C5 C7, inconsistent C8 T1 good C6. Early surgical correction improved function...
Kessler's extensor pollicis brevis (EPB) palmar tendon sling is a simple and reliable reconstruction for symptomatic instability of the thumb metacarpophalangeal (MP) joint. However, we encountered subluxation longus extension lag at MP joint when entire was used. We modified technique, splitting to preserve its function as an extensor. Six joints with anteroposterior secondary hyperextension injury were reconstructed using split-EPB technique. At average 22 months postoperatively, all...
We retrospectively studied the possibility that direct trauma to biceps muscle might be cause of poor elbow flexion and supination in 18 consecutive children with birth lesions brachial plexus who had delayed or impaired recovery despite neurophysiological evidence reinnervation. All good shoulder hand function at three months age. Eight recovered a strong after six months, but nine required pectoralis minor transfer augment supination. One microsurgical reconstruction plexus. clinical...