Abstract Multi-drug resistant (MDR) bacteria are considered a serious public health threat. Also, increasing rate of resistance to anticancer drugs, as well their toxicity, is another point concern. Therefore, the new antibacterial and agents always needed. The synthesizing silver nanoparticles (AgNPs) using medicinal plants, an effective approach for developing novel agents. Rubus discolor , native species Caucasus region, produces leaves that typically discarded by-product raspberry...

Acrylamide (AA) is a toxic chemical compound found in cooked foods. Considerable evidences suggest that oxidative stress and mitochondrial dysfunction are contributed to AA toxicity. Ceric oxide (CeO2) nanoparticles (nano-ceria) have the potential be developed as therapeutic for insults due their catalytic antioxidant properties. In this study we investigated, whether nano-ceria exerted protective effect against AA-induced cytotoxicity damage. HepG2 human cancer cell lines were exposed (50,...

The dietary inflammatory index (DII) is a common grading system for diet potential. Recent investigations link DII to hematopoietic malignancies. However, the relationship between and Multiple myeloma (MM) unknown. MM were examined in present case–control study of Iranian adults. This case–controlstudy was conducted on adults aged 20 75 years, selecting 149 cases with newly diagnosed multiple 359 healthy individuals. Dietary assessment using validated semi-quantitative food frequency...

One of the most common strategies in treatment cognitive disorders is enhancing acetylcholine level brain through inhibition acetylcholinesterase. Despite effectiveness current modern drugs, more attention has been paid for finding new anticholinesterase agents from medicinal plants. Zatraia multiflora Boiss. an endemic plant to Iran which different uses traditional medicine as anti-inflammatory, antimicrobial, anti spasmodic. We intended evaluate vitro and free radical scavenging activity...

Methamphetamine (METH) is widely abused in worldwide. METH use could damage the dopaminergic system and induce neurotoxicity via oxidative stress mitochondrial dysfunction. Propofol, a sedative-hypnotic agent, known for its antioxidant properties. In this study, we used propofol attenuating of METH-induced rats.

Acrylamide (ACR), with high prevalence in starchy food, has been associated the development of several organ toxicities such as immunotoxicity. This study aimed to demonstrate role oxidative stress and apoptosis mechanisms involved ACR-induced immunotoxicity mice. Mice were randomly assigned six groups treated follows: control (normal saline), cyclophosphamide (200 mg kg –1 ), ACR (12.5, 25 50mg , orally), l-carnitine (l-CAR; 100 ) + (50 ). After 30 days exposure, mice killed immunotoxic...

Schizophrenia is a chronic mental complaint known as cognitive impairment. There has been evidence that inflammation and oxidative stress play main role in schizophrenia pathophysiology. This study aimed to investigate the effects of l-carnitine, potent antioxidant, on treatment behavioural biochemical disturbances mice with ketamine-induced schizophrenia. In this study, was induced by ketamine (25 mg/kg/day, i.p). Before induction schizophrenia, were treated l-carnitine (100, 200, 400 Then,...

Diazinon (Dz) is a widely used insecticide. It can induce nephrotoxicity and neurotoxicity via oxidative stress. Captopril, an angiotensin-converting enzyme inhibitor, known for its antioxidant properties. In this study, we captopril ameliorating of Dz-induced kidney brain toxicity in rats. Animals were divided into five groups as follows: negative control (olive oil), Dz (150 mg kg−1), (60 100 kg−1) positive (N-acetylcysteine 200 injected intraperitoneally 30 min before Dz. After 24 h,...

Acrylamide (AA), is an important industrial compound, formed during food processing under high temperature. Due to its potential carcinogenic effect, it has been recognized as a human health concern. In this study, we investigated the role of oxidative stress in acrylamide’s genotoxicity and protective L- carnitine (LCA) lymphocytes. The micronucleus test (MNT) was used monitor AA after 20h exposure concentrations 0.25,50 100 mM. Furthermore evaluated markers, such reactive oxygen species...

The aim of this study was to evaluate the toxic effect AlNPs on rat brain mitochondria and compare it with that aluminium's ionic form.Mitochondria were isolated from brain. Isolated treated normal saline (Control) different concentrations aluminium ions (AlIs) (50, 100 200 μM). Then, electron transport chain complexes as well various endpoints such mitochondrial oxidative damage (reactive oxygen species, lipid peroxidation, glutathione, protein carbonyl) function assessed. Also, apoptosis...

Abstract Background The placement of liners near the pulp area is essential for therapeutic effects and maintaining health while stimulating formation tertiary dentin. This in vitro study aimed to evaluate calcium release, pH, biocompatibility, solubility, bioactivity three resin-modified hydroxide cavity liners. Methods disc specimens each liner were prepared using polyethylene molds 7 mm diameter 2 height ( n = 10). Three light-cure evaluated include Ultra-Blend Plus (UB), Base-it (BI),...

The aim of this study was to evaluate the role inflammation and oxidative damage in hepatotoxicity ethanol. Also we assessed protective effects atorvastatin against ethanol-induced hepatotoxicity. In study, animals were divided into five groups: control, ethanol (10 mg/kg intraperitoneal (i.p.)), with (10, 20 mg/kg/day, i.p.) ethanol-vitamin C group which received mg/kg/day) plus vitamin (200 mg/kg, for 28 consecutive days. Then, euthanized liver tissues separated. Biochemical markers ALT...

Background: Diabetes is the growing health problem worldwide and increasing diabetes prevalence has been reported in most countries.Several mechanisms are suggested for diabetic nephropathy that oxidative stress important one.In this study efficiency of nanoceria (a potent antioxidant) was evaluated attenuation mice.Materials Methods: Mice were divided into five groups, each comprising 6 mouse, induced by a single dose streptozocin (65 mg kgG 1 b.wt., IP) diluted citrate buffer (pH =...

A waterborne-polyurethane (WPU) dye, based on the fluorescent dye 4-diamino propane-N-allyl-1,8- naphthalimide (WPU-DAN), was synthesized by attaching (DAN) onto both ends of polyurethane (PU) chains according to a prepolymer−ionomer process. The synthetic process confirmed Fourier transform infrared spectroscopy (FTIR) and UV-visible absorption. glass transition temperature, molecular weight average particle sizes were measured. temperatures WPU WPU-DAN 46.6 49.8°C, respectively. In...

Background and purpose: Indomethacin is one of the most widely used non-steroidal anti-inflammatory drugs. This study aimed to investigate protective effects curcumin against indomethacin-induced genotoxicity. Experimental approach: For in vitro studies, human peripheral blood lymphocytes were obtained from a healthy volunteer treated for 24 h as follows: vehicle control, indomethacin at 100 200 μΜ, (100 μM μM) plus (27 μM). vivo experiments, mice received single i.p dose mg/kg) after 30 min...

This study explores the impact of brown rice bran powder (BRBP), known for its beneficial components, such as dietary fiber and γ-oryzanol, on individuals suffering from metabolic syndrome (MetS).