<h3>Objective.</h3> —To determine the relationship of brain infarction to clinical expression Alzheimer disease (AD). <h3>Design.</h3> —Cognitive function and prevalence dementia were determined for participants in Nun Study who later died. At autopsy, lacunar larger infarcts identified, senile plaques neurofibrillary tangles neocortex quantitated. Participants with abundant some classified as having met neuropathologic criteria AD. <h3>Setting.</h3> —Convents Midwestern, Eastern, Southern...

Handwritten autobiographies from 180 Catholic nuns, composed when participants were a mean age of 22 years, scored for emotional content and related to survival during ages 75 95. A strong inverse association was found between positive in these writings risk mortality late life (p < .001). As the quartile ranking emotion early increased, there stepwise decrease resulting 2.5-fold difference lowest highest quartiles. Positive early-life strongly associated with longevity 6 decades later....

In Reply. —The analyses of Drs Mirra and Gearing indicate that brain infarcts are not associated with NFTs in the neocortex. Our also indicated were number NFTs, senile plaques, or neuritic plaques neocortex, suggesting AD lesions likely to have occured independently each other. While infarction may represent separate disease processes, their combination nonetheless increase likelihood dementia will occur. Among participants our study who met neuropathologic criteria for (ie, abundant some...

<h3>Objective.</h3> —To determine if linguistic ability in early life is associated with cognitive function and Alzheimer's disease late life. <h3>Design.</h3> —Two measures of life, idea density grammatical complexity, were derived from autobiographies written at a mean age 22 years. Approximately 58 years later, the women who wrote these participated an assessment function, those subsequently died evaluated neuropathologically. <h3>Setting.</h3> —Convents United States participating Nun...

The development of interventions designed to delay the onset dementia highlights need determine neuropathologic characteristics individuals whose cognitive function ranges from intact demented, including those with mild impairments. We used Braak method staging Alzheimer's disease pathology in 130 women ages 76-102 years who were participants Nun Study, a longitudinal study aging and disease. All had complete autopsy data free conditions other than lesions that could affect function....

The Nun Study is a longitudinal study of 678 Catholic sisters 75 to 107 years age who are members the School Sisters Notre Dame congregation. Data collected for this include early and middle-life risk factors from convent archives, annual cognitive physical function evaluations during old age, postmortem neuropathologic participants' brains. case histories presented centenarian was model healthy aging, 92-year-old with dementia clinically significant Alzheimer disease neuropathology vascular...

Findings described in this report are for 6,763 white male Seventh-day Adventists who completed a dietary questionnaire 1960. Between 1960 and 1980 mortality data were collected on cohort members. Overweight men had significantly higher risk of fatal prostate cancer than near their desirable weight. The predicted relative was 2.5 overweight men. Suggestive positive associations also seen between the consumption milk, cheese, eggs, meat. There an orderly dose-response each four animal...

The relation between age at natural menopause and all-cause mortality was investigated in a sample of 5,287 White women, ages 55 to 100 years, naturally-postmenopausal, Seventh-day Adventists who had completed mailed questionnaires 1976. age-adjusted odds ratio death during 1976-82 women with before 40 1.95 (95% confidence interval = 1.24, 3.07), compared the reference group reporting 50 54. Corresponding ratios were 1.39 CI 1.06, 1.81) for 44, 1.03 0.84, 1.25) 45 49. Among 3,166 White, 55-...

<b><i><i>Objective:</i></i></b> To determine whether hippocampal volume is a sensitive and specific indicator of Alzheimer neuropathology, regardless the presence or absence cognitive memory impairment. <b><i><i>Methods:</i></i></b> Postmortem MRI scans were obtained for first 56 participants Nun Study who scanned. The area under receiver operating characteristic curves, sensitivity, specificity, positive negative predictive values used to assess diagnostic accuracy in predicting fulfillment...

Sister Mary, the gold standard for Nun Study, was a remarkable woman who had high cognitive test scores before her death at 101 years of age. What is more that she maintained this status despite having abundant neurofibrillary tangles and senile plaques, classic lesions Alzheimer's disease. Findings from Mary all 678 participants in Study may provide unique clues about etiology aging disease, exemplify what possible old age, show how clinical expression some diseases be averted.

To examine the prevalence of dementia associated with having a smaller brain, lower education or both these characteristics, 294 Catholic sisters were assessed annually for dementia. Sixty participants died and their brains evaluated to determine fulfillment neuropathological criteria Alzheimer's disease (AD). Lower educational attainment interaction head circumference presence dementia, controlling age one more apolipoprotein E-epsilon 4 alleles. By contrast, neither low nor was...

We propose the hypothesis that a vegetarian diet reduces risk of developing diabetes. Findings have generated this are from population 25,698 adult White Seventh-day Adventists identified in 1960. During 21 years follow-up, diabetes as an underlying cause death was approximately one-half for all US Whites. Within male Adventist population, vegetarians had substantially lower than non-vegetarians or contributing death. both and female populations, prevalence self-reported also...

Associations between fatal colon or colorectal cancer and frequency of use meat, cheese, milk, eggs, green salad, coffee, as well percent desirable weight, are described with the 21 years follow-up for 25,493 white California Seventh-Day Adventists. presented in terms relative risk (RR) heavy light exposure versus rare exposure. There were no clear relationships evident rectal salad use. Egg was positively associated both males (RR = 1.6) females 1.7). Coffee mortality females, particularly...

The potential of early interventions for dementia has increased interest in cognitive impairments less severe than dementia. However, predictors the trajectory from intact cognition to have not yet been clearly identified. purpose this study was determine whether known risk factors mild or progression A polytomous logistic regression model used, with parameters governing transitions within transient states (intact cognition, impairments, global impairment) estimated separately transition...

Clinical supervision is recommended for allied health professionals the purpose of supporting them in their professional role, continued development and ensuring patient safety high quality care. The aim this mixed methods study was to explore professionals' perceptions about aspects clinical that can facilitate effective supervision.Individual semi-structured interviews were conducted on a purposive sample 38 working metropolitan public hospital. Qualitative analysis completed using an...