A5039103696- Neural Networks and Applications
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- Spinal Cord Injury Research
- Neurological disorders and treatments
- Ion channel regulation and function
- Zebrafish Biomedical Research Applications
- Musculoskeletal pain and rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiac electrophysiology and arrhythmias
- Speech and Audio Processing
- Noise Effects and Management
- Shoulder Injury and Treatment
- Motor Control and Adaptation
- CCD and CMOS Imaging Sensors
- Medical Imaging and Pathology Studies
- Cell Image Analysis Techniques
- Functional Brain Connectivity Studies
- Nerve Injury and Rehabilitation
University of Arkansas at Fayetteville
2022-2025
Innovative Research (United States)
2024-2025
Semmelweis University
2025
Florida International University
2015-2024
Medical University of South Carolina
2017
Shirley Ryan AbilityLab
2017
Methodist Rehabilitation Center
2017
VA Boston Healthcare System
2017
Harvard University
2017
Rehabilitation Hospital of Indiana
2017
A 10nm logic platform technology is presented for low power and high performance application with the tightest contacted poly pitch (CPP) of 64nm metallization 48nm ever reported in FinFET on both bulk SOI substrate. 0.053um<sup>2</sup> SRAM bit-cell a corresponding Static Noise Margin (SNM) 140mV at 0.75V. Intensive multi-patterning various self-aligned processes have been developed 193i lithography to overcome optical patterning limit. Multi-workfunction (WF) gate stack has enabled provide...
Rodent models are being extensively used to investigate the effects of traumatic injury and develop assess mechanisms repair regeneration. We present quantitative assessment two-dimensional (2D) kinematics overground walking for first time three-dimensional (3D) joint angle all four limbs during treadmill in intact adult female Long-Evans rats. Gait cycle with subphases intralimb interlimb cyclograms presented. Phase relationships between angles on a cycle-by-cycle basis footfalls assessed...
Abstract Objective: Electrical stimulation of peripheral nerves is used to treat a variety disorders and conditions. While conventional biphasic pulse typically induces neural activity in fibres, kilohertz (kHz) continuous can block conduction, offering promising alternative drug-based therapies for alleviating abnormal activity. This study explores strategies enhance the selectivity control high-frequency conduction using intrafascicular electrodes. Methods: In vivo experiments were...
We present a novel demonstration of real-time dynamic interaction between an oscillatory spinal cord (isolated lamprey nervous system) and electronic hardware that mimics the motor pattern generating circuitry. The neuromorphic circuit were interfaced in unidirectional bidirectional modes. Bidirectional coupling resulted stable, persistent oscillations. This experimental platform offers unique paradigm to examine intrinsic dynamics neural analog very large scale integration (aVLSI) design...
1. Experimental studies have shown that a central pattern generator in the spinal cord of lamprey can produce basic rhythm for locomotion. This interacts with reticular neurons forming spinoreticulospinal loop. To better understand and investigate mechanisms locomotor generation lamprey, we examine dynamic behavior simplified neural network model representing unit (uPG) its interaction system. We use techniques bifurcation analysis specifically effects on system 1) changing tonic drives to...
Current myoelectric prosthetic limbs are limited in their ability to provide direct sensory feedback users, which increases attentional demands and reliance on visual cues. Vibrotactile substitution (VSS), can be used a non-invasive manner has demonstrated some improvement hand control. In this work, we developed tested two VSS configurations: one with single burst-rate modulated actuator another spatially distributed array of five coin tactors. We performed comparative assessment these...
Background: Estimating survival and long-term quality of life after intensive care has been a crucial bioethical endeavour in recent decades to improve end-of-life decision-making. Scientific studies have also shown that patient frailty influences survival, but only few data are available. Methods: We conducted prospective observational study at the Department Anaesthesiology Intensive Care Semmelweis University, Hungary, investigate association between physical status on admission, chance...
The discharge properties of hindlimb motoneurons in ketamine-xylazine anesthetized rats were measured to assess contributions persistent intrinsic currents these characteristics and determine their distribution motoneuron pools. Most (30/37) responded ramp current injections with adapting patterns the frequency-current (f-I) relations nearly all included a steep subprimary range discharge. Despite prevalence f-I relations, responses indications that inward (PICs) activated, including...
Preterm birth (PTB) presents a serious medical health concern throughout the world. There is high incidence of PTB in both developed and developing countries ranging from 11% to 15%, respectively. Recent research has shown that cervical collagen orientation distribution changes during pregnancy may be useful predicting PTB. Polarization imaging an effective means measure optical anisotropy birefringent materials, such as cervix's extracellular matrix. Noninvasive, full-field Mueller matrix...
Studienziel: Bestimmung der Prävalenz von Fußschmerzen und Fußdeformierungen bei Adoleszenten. Ermittlung des Zusammenhangs zwischen Fußschmerzen. Methode: Bei 2 368 Adoleszenten im Alter 14,5 ± 0,7 Jahren wurde die Rahmen schulärztlichen Untersuchung ermittelt. Ergebnisse: Die betrug 14,0 %. 13,7 Jugendliche, klinischen eine Fußdeformierung demonstrierten, hatten signifikant höhere Schmerzprävalanz (17,8 %) als fußgesunde Jugendliche (13,4 %). 6,2 % lag ein flexibler Knick-Senk-Fuß 0,5...
We report here the first direct measurements of persistent inward currents (PICs) in rat hindlimb motoneurons, obtained from ketamine-xylazine anesthetized rats during slow voltage ramps performed by single-electrode somatic clamp. Most motoneurons expressed PICs and current-voltage (I-V) relations often contained a negative-slope region (NSR; 13/19 cells). activated at -52.7 ± 3.89 mV, 9 mV negative to spike threshold. NSR onset was -44.2 4.1 mV. PIC amplitudes were assessed maximum...
The mechanisms underlying the effects of neuromuscular electrical stimulation (NMES) induced repetitive limb movement therapy after incomplete spinal cord injury (iSCI) are unknown. This study establishes capability using therapeutic NMES in rodents with iSCI and evaluates its ability to promote recovery interlimb control during locomotion. Ten adult female Long Evans rats received thoracic contusion injuries (T9; 156 +/- 9.52 Kdyne). 7 days post-recovery, 6/10 animals for 15 min/day 5 days,...
Spasticity is commonly observed after chronic spinal cord injury (SCI) and many other central nervous system disorders (e.g., multiple sclerosis, stroke). SCI-induced spasticity has been associated with motoneuron hyperexcitability partly due to enhanced activation of intrinsic persistent inward currents (PICs). Disrupted inhibitory mechanisms also have implicated. Altered inhibition can result from complex changes in the strength, kinetics, reversal potential (E(Cl(-))) γ-aminobutyric acid...