A5056445079- Neonatal Respiratory Health Research
- Ziziphus Jujuba Studies and Applications
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Gut microbiota and health
- Climate Change and Health Impacts
- Ginseng Biological Effects and Applications
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Insect Pest Control Strategies
- Neuropeptides and Animal Physiology
- Bacterial biofilms and quorum sensing
- Agricultural pest management studies
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Phytochemistry and biological activities of Ficus species
- Piperaceae Chemical and Biological Studies
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Dendrimers and Hyperbranched Polymers
Brown University
2021-2024
University of Connecticut
2023-2024
Rhode Island Hospital
2022-2023
Anna University, Chennai
2017-2023
Bharathidasan University
2017-2020
Lung cancer is the leading cause of related deaths both in developed and developing countries. Since majority existing therapeutic methods harms normal malignant cells, a viable alternative to switch into safe beneficial traditional medicinal plants. Hence present study was framed identify selective anti-lung agents from plant Grewia tiliaefolia (GT). Cell viability experiments showed that benzene extract GT (BGT) leaf effectively inhibited growth A549 while being non-toxic human lung L132...
Quorum Sensing (QS) mechanism, a bacterial density-dependent gene expression system, governs the S. marcescens pathogenesis through production of virulence factors and biofilm formation. The present study demonstrates anti-quorum sensing (anti-QS), antibiofilm potential in vivo protective effect phytol, diterpene alcohol broadly utilized as food additive therapeutics fields. In vitro treatment phytol (5&10 µg/ml) showed decreasing level formation, lipase hemolysin compared to their...
Ziziphus mauritiana (Rhamnaceae), commonly known as jujuba Mill, is in traditional Chinese medicine enriched with high medicinal values. In Indian and medicine, a decoction of leaves was used to cure insomnia, amnesia, pain, vertigo. The study aims determine the analgesic, anti-inflammatory, antipyretic activities Lam establish rationale for their use. We studied analgesic activity by writhing hot plate methods mice, whereas mechanical allodynia rats. Also, rats were carrageenan...
Particulate matter in the air exacerbates airway inflammation (AI) asthma; moreover, prenatal exposure to concentrated urban particles (CAPs) and diesel exhaust (DEPs) predisposes offspring asthma worsens resolution of AI response allergens. We previously tested hypothesis that such impairs pathways specialized proresolving mediators are critical for found declined Lipoxin A4 (LxA4) Resolvin E2 (RvE2) levels "at-risk" pups exposed mothers. Here, we hypothesized supplementation with synthetic...
Background: Antitumor research aims to efficiently target hepatocarcinoma cells (HCC) for drug delivery. Nanostructured lipid carriers (NLCs) are promising active tumour targeting. Cell-penetrating peptides feasible ligands targeted cancer treatment. Methods: In this study, we optimized gefitinib-loaded NLCs (GF-NLC) HCC The contained cholesterol, oleic acid, Pluronic F-68, and Phospholipon 90G. NLC surface was functionalized enhance targeting with the cRGDfK-pentapeptide, which binds αvβ 3...
Staphylococcal infections associated with indwelling medical devices are difficult to eradicate owing its recalcitrant nature of biofilms conventional antibiotics. In our earlier study, we reported the efficacy geraniol (GE) in inhibiting vitro biofilm formation Staphylococcus epidermidis and adaptive resistant development. To examine vivo potential GE eradicating colonization S. epidermidis, an implanted rat jugular vein catheter model was developed. Oral supplementation (GE at 200 mg/kg bw...
The aim of the present study is to analyze methanol extract Ziziphus mauritiana Lam leaves for its chemical composition using gas chromatographymass spectroscopy (GC-MS) analysis correlating in-vitro anti-oxidant, in vivo-anti-inflammatory activity and determine total phenolic & flavonoid contents.The processed plant material was extracted methanol.Phytochemical profiling revealed presence flavonoids, terpenoids, alkaloids glycosides.The antioxidant extracts determined...
Maternal gestational exposures to traffic and urban air pollutant particulates have been linked increased risk and/or worsening asthma in children; however, mechanisms underlying this vertical transmission are not entirely understood. It was postulated that particle exposure might affect the ability elicit specialized proresolving mediator (SPM) responses upon allergen encounter neonates. Lipidomic profiling of 50 SPMs performed lungs neonates born mice exposed concentrated particles (CAP),...