A5025713649- Thyroid Disorders and Treatments
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Stress Responses and Cortisol
- Clinical Reasoning and Diagnostic Skills
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Parathyroid Disorders and Treatments
- Clinical Laboratory Practices and Quality Control
- Pneumocystis jirovecii pneumonia detection and treatment
- Bone health and treatments
- Meta-analysis and systematic reviews
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Advanced Computational Techniques and Applications
- Vitamin D Research Studies
- Fecal contamination and water quality
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Amoebic Infections and Treatments
- Neuroscience of respiration and sleep
- Alkaline Phosphatase Research Studies
- Heterotopic Ossification and Related Conditions
- Neonatal Health and Biochemistry
The Royal Wolverhampton NHS Trust
2021-2024
New Cross Hospital
2021-2022
University of Warwick
2019
Coventry (United Kingdom)
2019
Abstract Objective We assessed the commutativity of Roche and Abbott thyroid assays in diagnosis management subclinical hypothyroidism (SCH). The are used by approximately 75% clinical laboratories UK. Method Consecutive samples received from primary care on patients with SCH who had a raised thyroid‐stimulating hormone (TSH) <10 mIU/L normal free thyroxine (fT4) two using either or were identified over 10 working days. Following identification, analysed at other site within 24 hours....
We assessed the impact of intact parathyroid hormone (iPTH) and adjusted calcium analyses on Abbott, Roche Siemens analytical platforms in diagnosis normocalcaemic primary hyperparathyroidism (NCPHPT). These assays are used by over 85% clinical laboratories UK. Over five months, consecutive serum samples from outpatients with NCPHPT laboratory Abbott were identified, aliquoted stored at -80°C. Frozen aliquots transported monthly to other two laboratories. After thawing, mixed analysed...
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Serum total testosterone (T) decreases postprandially. Postprandial salivary (SalT) responses, however, have not been studied. We report on the effect of glucose ingestion fasting SalT concentrations.
Simulated freshly passed stools containing motile Entamoeba moshkovskii trophozoites were examined by direct wet mount and permanent (Trichrome) staining techniques. The percentage of detection was 4.8%. the plus stain 58.5%. Laboratorians should be cautioned not to rely solely on for or identification protozoan trophozoites.
Thyroid stimulating hormone (TSH) assays provided by Abbott Laboratories and Roche Diagnostics are used approximately 75% of laboratories in the UK. We assessed potential impact TSH assay differences on biochemical assessment levothyroxine replacement primary hypothyroidism.Samples from 100 consecutive care patients (83 women, median age 64 years, IQR 51-73 years) with hypothyroidism adequate based an Architect reference range were analysed for cobas within 24 hours. The results compared....
Communication between the maternal endometrium and developing embryo/conceptus is critical to support successful pregnancy term. Studying peri-implantation period of as this when most loss occurs in cattle. Our current understanding these interactions limited, due lack appropriate vitro models assess interactions. The a complex heterogeneous tissue that regulated transcriptional translational manner throughout oestrous cycle. While there are study endometrial function, they static 2D nature...
In samples from patients administered rasburicase, ex vivo uricolysis leads to spuriously low uric acid results. The manufacturer's recommendation of storing the sample in ice-water until analysis, however, does not fully arrest uricolysis. Since uricase activity is affected by pH and metal chelators, we assessed inhibition sodium fluoride-ethylenediaminetetraacetic (EDTA)-citrate tube (FC Mix tube, Greiner) used primarily for plasma glucose.A serum pool was spiked with rasburicase measured...
A large discordance in the diagnosis and potential management of hypothyroidism using Abbott Roche thyroid assays has been reported recently. The difference thyroid-stimulating hormone (TSH) results these studies was larger than anticipated from external quality assessment (EQA) reports.Abbott TSH method means UK NEQAS for hormones distributions 430 to 454 were compared against amount spiked. deplete serum pool spiked with various concentrations pooled high 3rd WHO International Standard...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Mycobacterium tuberculosis (Mtb) is the causative agent of (TB) and has evolved an incredible ability to survive latently within human host for decades. The Mtb pathogen encodes a low number ATP-binding cassette (ABC) importers acquisition carbohydrates that may reflect nutrient poor environment macrophages. UgpB (Rv2833) substrate binding domain UgpABCE transporter recognises glycerophosphocholine (GPC) indicating potential role in glycerophospholipid recycling. By using...