A5072537738- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Catalytic Cross-Coupling Reactions
- Advanced biosensing and bioanalysis techniques
- Neuroblastoma Research and Treatments
- Synthetic Organic Chemistry Methods
- Advanced Nanomaterials in Catalysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- X-ray Diffraction in Crystallography
- Electrochemical Analysis and Applications
- Graphene and Nanomaterials Applications
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Asymmetric Hydrogenation and Catalysis
- Advanced Drug Delivery Systems
- Catalytic Alkyne Reactions
- Bone health and treatments
- Angiogenesis and VEGF in Cancer
- Bone Tissue Engineering Materials
- Laser Applications in Dentistry and Medicine
Universidad Complutense de Madrid
2017-2023
Universidad de Málaga
2022
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2015-2019
Centro de Investigación Biomédica en Red
2015-2019
Instituto de Ciências Farmacêuticas
2018
Research Institute Hospital 12 de Octubre
2018
Instituto de Ciencia de Materiales de Madrid
2011-2012
Instituto de Química Orgánica General
2011
Consejo Superior de Investigaciones Científicas
2010
A series of gold complexes were tested as catalysts in the synthesis propargylamines by three component coupling reaction amines, aldehydes, and alkynes. These are efficient for three-component (yields up to 97%). In homogeneous solution, conversions respective propargylamine higher than under heterogeneous conditions. Heterogenized stable recoverable at least six cycles. Ligands, gold(I) or gold(III), heterogenized systems have pronounced effects on catalytic activity corresponding complexes.
The development of targeted nanocarriers able to be selectively internalized within tumor cells, and therefore deliver anti-tumor drugs specifically diseased constitutes one the most important goals in nano-oncology. Herein, Janus mesoporous silica particles asymmetrically decorated with two targeting moieties, them selective for folate membrane cell receptors (folic acid) other bind mitochondria (triphenylphosphine, TPP), is described order achieve sequential organelle vectorization....
Biscarbene ligands with two imidazolin-2-ylidene moieties at a chiral dioxolane backbone were used as for gold, rhodium and palladium complexes. All new complexes showed varying degrees of enantioselectivity toward hydrogenation prochiral alkenes ees up to 95%.
Novel targeting agents against neuroblastoma based on the meta-iodobenzylguanidine (MIBG) moiety were synthesized and biologically evaluated for nanocarrier vectorization. These compounds have been anchored surface of drug loaded mesoporous silica nanocarriers, resulting in improved cellular uptake tumoral cells. Neuroblastoma (NB) is most frequent extracranial pediatric tumor. Advanced forms disease (metastatic and/or refractory) a dismal prognosis despite combination chemotherapy,...
In this work we present the synthesis, characterization and in vitro biological evaluation of PEGylated actively-targeted ultrasound-responsive hybrid mesoporous silica nanoparticles. This covers development chemical strategies necessary to afford a modular nanocarrier starting from proof-of-concept material presented previous work. functional can be adapted different specific pathological conditions by carefully choosing appropriate targeting moieties. The new ultrasound responsive is able...
Ag2S semiconductor nanoparticles (NPs) are near-infrared luminescent probes with outstanding properties (good biocompatibility, optimum spectral operation range, and easy biofunctionalization) that make them ideal for in vivo imaging. NPs have, indeed, made possible amazing challenges including brain imaging advanced diagnosis of the cardiovascular system. Despite continuous redesign synthesis routes, emission quantum yield (QY) is typically below 0.2%. This leads to a low brightness avoids...
Abstract Rhodium, palladium, and gold complexes of chiral (NHC)–dioxolane–amino ligands were prepared. Herein, new methods for the heterogenization NHC‐chiral on porous silica supports are demonstrated facile recovery recycling these expensive catalysts. Activity, selectivity, recyclability investigated compared to that analogous homogeneous catalysts asymmetric hydrogenation reactions. The compounds characterized by using a variety methods, including solid state cross‐polarization...
We have fabricated an implantable dressing material able to reduce antipressure ulcer disease. This biomaterial is based on electrospun poly(lactic acid) (PLA) nanofibers (NFs) containing the hydroethanolic extract (HE) of T. ramosissimum. Optimized synthesis conditions (17-PLA/HE NFs) resulted in homogeneous and nonwoven mat structures formed by polymeric NFs. included a kinetic release assay where chemical main released compounds were identified using nuclear magnetic resonance. The...
Abstract Melanoma is one of the most severe public health issues worldwide, not only because high number cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. However, melanoma highly resistant to cytotoxicity metastatic form. In this context, therapeutic strategy based on targeted chemo‐photothermal nanotransporter cytotoxic compounds proposed. This approach comprises use core–multishell gold nanorods,...
The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as one the most important challenges in nanomedicine field. Meta-iodobenzilguanidine (MIBG) is widely used for diagnosis neuroblastoma (NB) due its strong affinity norepinephrine transporter (NET), usually overexpressed on membrane malignant cells. Herein, a family novel Y-shaped scaffolds synthesized, which have structural analogues MIBG covalently attached at each end Y-structure. cellular uptake...
Here, we report the fabrication of several hybrid bimetallic core@shell and core@shell@satellite colloidal nanostructures. These nanosystems are structured as spherical non-spherical metallic cores encapsulated by a thermo-responsive N-isopropylacrylamide (pNIPAM) shell (core@shell) with incorporated Ag satellites (core@shell@satellite). The include Au nanotriangles AuAg nanocubes, respectively. By using different amounts AgNO3 during chemical reduction through seed-mediated approach, able...
Abstract The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able recognize these cells. Unfortunately, simple and static systems show a lack in selectivity. Herein, double sequential encrypted system proposed as stimuli‐responsive analogue for selectivity enhancement. diseased bone tissue the first place, once there, hidden secondary group activated presence an enzyme overproduced malignant (cathepsin K),...
Ag
Chiral compounds prepared from proton sponge building block 8-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)naphthalen-1-amine were found to be effective chiral ligands for obtaining complexes of rhodium(I) and palladium(II) by reaction with [RhCl(cod)]2, PdCl2(cod) or Pd(OAc)2. The bearing triethoxysilane groups immobilized on mesoporous MCM-41 in order obtain new heterogeneous catalysts. Both materials are active the hydrogenation alkenes could recycled without loss activity enantioselectivity.
Abstract The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as one the most important challenges in nanomedicine field. Meta‐iodobenzilguanidine (MIBG) is widely used for diagnosis neuroblastoma (NB) due its strong affinity norepinephrine transporter (NET), usually overexpressed on membrane malignant cells. Herein, a family novel Y‐shaped scaffolds synthesized, which have structural analogues MIBG covalently attached at each end Y‐structure....
Abstract Biscarbene ligands with two imidazolin‐2‐ylidene moieties at a chiral dioxolane backbone are synthesized and used as for gold, rhodium palladium complexes.