A5048426778- Blood Pressure and Hypertension Studies
- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoparticle-Based Drug Delivery
- Synthesis and Reactivity of Heterocycles
- Sodium Intake and Health
- Catalytic Cross-Coupling Reactions
- Nanoplatforms for cancer theranostics
- Acute Myocardial Infarction Research
- Synthetic Organic Chemistry Methods
- Cardiovascular Health and Risk Factors
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Oxidative Organic Chemistry Reactions
- Mesoporous Materials and Catalysis
- Asymmetric Synthesis and Catalysis
- Nutritional Studies and Diet
- RNA Interference and Gene Delivery
- Heart Rate Variability and Autonomic Control
- Graphene and Nanomaterials Applications
- Healthcare Systems and Public Health
- Long-Term Effects of COVID-19
- Cancer therapeutics and mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
Universidad de Alcalá
2006-2025
Servicio de Salud de Castilla La Mancha
2025
Davao Doctors Hospital
2018-2023
Doctors Hospital
1990-2023
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2022
Universidad Complutense de Madrid
2016-2022
Philippine General Hospital
2020-2022
Philippine Medical Association
2022
Universidad Ricardo Palma
2021
Centro de Investigación Biomédica en Red
2017-2020
BackgroundIncreased blood pressure is the biggest contributor to global burden of disease and mortality. Data suggest that less than half population with hypertension aware it. May Measurement Month was initiated raise awareness importance as a pragmatic interim solution shortfall in screening programmes.MethodsThis cross-sectional survey included volunteer adults (≥18 years) who ideally had not their pressures measured past year. Each participant three times received questionnaire about...
Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide fewer than half of those with hypertension are aware it. May Measurement Month (MMM) a global campaign set up in 2017, raise awareness high BP as pragmatic solution lack formal screening worldwide. The 2018 was expanded, aiming include more participants countries.
Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, immune-modulating effects may address key pathophysiologic mechanisms in development progression of acute respiratory distress syndrome (ARDS), which implicated as likely cause death COVID19. We aimed describe observable clinical tolerability high-dose melatonin (hdM) given adjuvant therapy...
A practical copper-catalyzed direct nitration of protected anilines, by using one equivalent nitric acid as the nitrating agent, has been developed. This procedure features mild reaction conditions, wide structural scope (with regard to both N-protecting group and arene substitution), high functional-group tolerance. Dinitration with two equivalents is also feasible.
The synthesis of Mobil Composition Matter 41 (MCM-41) mesoporous silica nanoparticles (MSNs) controlled sizes and porous structure has been performed at laboratory pilot plant scales. Firstly, the effects main operating conditions (TEOS –Tetraethyl ortosilicate– addition rate, nanoparticle maturation time, temperature, CTAB –Cetrimonium bromide– concentration) on scale (1 L round-bottom flask) were studied via a Taguchi experimental design. Subsequently, profound one-by-one study was...
A crucial challenge to face in the treatment of biofilm-associated infection is ability bacteria develop resistance traditional antimicrobial therapies based on administration antibiotics alone. This study aims apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for combination therapy against biofilm. The design nanosystem antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized thermo-responsive...
Satisfaction with the inhaler is an important determinant of treatment adherence in patients asthma and chronic obstructive pulmonary disease (COPD). However, few studies have compared these 2 groups to identify factors associated satisfaction inhaler. To assess compare or COPD determine variables high satisfaction. A multicenter, cross-sectional study 816 (406 410 COPD) was conducted. assessed Feeling Inhaler (FSI-10) questionnaire. All participants completed Test Adherence Inhalers either...
Abstract Cells are sensitive to the physical properties of their microenvironment and transduce them into biochemical cues that trigger gene expression alter cell behavior. Numerous proteins, including integrins, involved in these mechanotransductive events. Here, a novel role for boron transporter NaBC1 is identified as mechanotransducer. It demonstrated soluble ions activate enhance adhesion intracellular tension C2C12 myoblasts seeded on fibronectin‐functionalized polyacrylamide (PAAm)...
The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as one the most important challenges in nanomedicine field. Meta-iodobenzilguanidine (MIBG) is widely used for diagnosis neuroblastoma (NB) due its strong affinity norepinephrine transporter (NET), usually overexpressed on membrane malignant cells. Herein, a family novel Y-shaped scaffolds synthesized, which have structural analogues MIBG covalently attached at each end Y-structure. cellular uptake...
Raised blood pressure is the biggest single risk factor responsible for mortality worldwide. Despite this, majority of people with hypertension are unaware having it, untreated, or on treatment but uncontrolled. May Measurement Month a global campaign initiated by International Society Hypertension aim raising awareness high pressure. In first year in 2017, over 1.2 million were screened 80 countries across world, finding 100 000 who not and 150 anti-hypertensive controlled. The individual...
Abstract The synthesis of 7‐hydroxypyrido[2,1‐ a ]isoquinolinylium salts can be achieved in moderate yields by intramolecular radical arylation pyridinium obtained from substituted pyridines and o ‐bromophenacyl bromides.
Despite the claim that encapsulation of drugs improves therapeutic profile free drugs, there are still important limitations in drug delivery. With respect to cancer treatment, two promising implementations combination therapy and targeted devices, which aimed at increasing effect either by achieving higher cell death rates or discriminating between populations. However, for time being, scope combining both approaches is unknown. To advance this knowledge, a two-drug-delivery system with...
Side effects and their relationship with the material used were analyzed in 748 plasma exchanges (PE) performed 75 patients. The total incidence of acute mild adverse (chills and/or fever, paraesthesias, allergic reactions, anaemia, vasovagal abdominal pain hypotension) was 18.04%. Two patients developed an episode left cardiac insufficiency. One patient whom all PE fresh frozen (FFP) metabolic alkalosis. Three sepsis during treatment repeated immunosuppressive drugs; these three a permanent...