A5023279826- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive tract infections research
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Cervical Cancer and HPV Research
- Syphilis Diagnosis and Treatment
- Urinary Tract Infections Management
- Neonatal Health and Biochemistry
- Thermal Regulation in Medicine
- Tuberculosis Research and Epidemiology
- Neuroscience of respiration and sleep
- Ion channel regulation and function
- Infectious Diseases and Tuberculosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cannabis and Cannabinoid Research
- Proteoglycans and glycosaminoglycans research
- Neuropeptides and Animal Physiology
- Immune Response and Inflammation
- Hemoglobin structure and function
- Peroxisome Proliferator-Activated Receptors
- Angiogenesis and VEGF in Cancer
- High Altitude and Hypoxia
- Ion Channels and Receptors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University College London
2000-2024
Post Graduate Institute of Medical Education and Research
2013
Florida Department of Health
1993-2012
University of Alabama at Birmingham
2005
William Harvey Research Institute
1994-2005
United States Department of State
2003-2005
St. Joseph’s Healthcare Hamilton
2005
Grady Health System
2005
Inserm
2003
SangStat Medical Corporation
2003
In Brief Background: Vaginal swabs were recently U.S. Food and Drug Administration-cleared for detecting Chlamydia trachomatis (CT) Neisseria gonorrhoeae (GC) using Gen-Probe Incorporated's APTIMA COMBO2 Assay (AC2). We assessed the CT (ACT) CT, GC (AGC) GC, AC2 both organisms patient- clinician-collected vaginal swabs. Method: Women attending family planning, obstetrics gynecology, or sexually transmitted disease (STD) clinics had first-catch urines (FCUs), patient-collected swabs,...
Abstract Genetic knock-out in mice of peroxisome proliferator-activated receptor-α (PPARα) can prolong inflammation response to leukotriene B4. Although cyclooxygenase 2 has been shown be induced by PPAR activation, the effect agonists on key inflammatory enzyme systems nitric oxide synthase (NOS) and stress proteins not investigated. The these naturally occurring eicosanoid (leukotriene B4 8(S)-hydroxyeicosatetraenoic acid, which are PPARα selective; PGA2, PGD2, PGJ2, Δ12PGJ2, PPARγ...
ABSTRACT The greater sensitivity of nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoeae permits the use urine other noninvasive specimens, which can increase reach decrease costs public health screening programs aimed at controlling these infections. This study evaluated performance APTIMA Combo 2 assay, a multiplex assay based on transcription-mediated reaction, simultaneous detection both pathogens in endocervical swab specimens from females....
1. The profiles of cyclo-oxygenase (COX) and nitric oxide synthase (NOS) isoforms were determined in the rat carrageenin-induced pleurisy model acute inflammation. 2. enzymes assessed peripheral blood leucocyte (PBL) cell pellets taken from untreated animals at 2, 6 24 h after injection irritant pleural exudate lung homogenates. 3. COX activity was by generation prostacyclin (PGI2, measured as stable metabolite, 6-keto prostaglandin F1 alpha) E2 (PGE2). Western blot analysis...
Self-collected specimens can be used to screen asymptomatic women for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC). We surveyed women's opinions on ease preferences as sampling after collecting their own vaginal swab urine a physician collection of cervical swab.In 7 North American cities, questionnaire was they participated in clinical trial nucleic acid amplification testing various specimens. A total 1,090 consenting gynecologic CT GC (82% those sampled) volunteered complete...
ABSTRACT A clinical evaluation was conducted in six North American centers to determine the ability of APTIMA CT (ACT) and GC (AGC) nucleic acid amplification assays detect Chlamydia trachomatis Neisseria gonorrhoeae infections 1,322 men by testing their urethral swabs first-catch urine (FCU). The results obtained with ACT AGC were compared an infected patient status determined specimens Combo 2 BD ProbeTec energy transfer multiplex assays. Symptoms did not influence values. Positive...
Lung cancer is the leading cause of deaths among American men, even though various treatments are available. The discovery and use new alternative drugs to treat lung cancers needed reduce mortality. Phytochemicals potentially desirable therapeutic agents due their better safety profiles. Isorhapontigenin (ISO) an orally bioavailable dietary stilbene. Our studies show that treatment with ISO inhibits human cell growth, angiogenesis, invasion, migration. Neural precursor expressed...
The bulk of published data has shown that NO is proinflammatory. However, there also exists the conflicting notion may be protective during an inflammatory insult. In attempt to resolve this issue, we have compared effects on inflammation a range synthase (NOS) inhibitors given either directly site lesion or systemically. It was found in carrageenin-induced pleurisy, single intrapleural injection selective inducible S-(2-aminoethyl) isothiourea (AE-ITU; 3 and 10 mg/kg)...
In Brief Background: The Gen-Probe APTIMA Combo 2 (AC2) assay is a second-generation transcription-mediated amplification for the detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). Goal: goal this study was to evaluate AC2 performance endocervical (cx) swabs CT NG using either specimen or an infected patient standard. Study Design: multicenter clinical study, we compared with Abbott's ligase chain reaction (LCR) Roche's polymerase (PCR; Amplicor COBAS) CT, LCR culture...
ABSTRACT The Centers for Disease Control and Prevention recommended confirming positive screening tests Chlamydia trachomatis when predictive values are <90%. It is accepted that less sensitive (i.e., culture immunoassays) should not be used to confirm the results of more nucleic acid amplification (NAATs). We show same principle applies NAATs confirmation.
Heme oxygenase (HO) is the rate-limiting enzyme in catabolism of heme to biliverdin, carbon monoxide (CO), and free iron. The exists as a constitutive isoform (HO-2) an inducible (HO-1), which also stress protein (HSP32). HO-1 has previously been shown be associated with resolution phase non-immune model acute inflammation. In addition, elevation was markedly anti-inflammatory. present study, these observations have extended two pleural models immune-driven inflammation rat, immediate type...
In recent years, there has been increasing interest in noninvasive monitoring of airway inflammation and oxidative stress. Several volatile nonvolatile substances can be measured exhaled breath have suggested as potential biomarkers these events. Exhaled gases, including carbon monoxide (CO), alkanes (ethane, pentane), condensate, such hydrogen peroxide (H 2 O ) isoprostanes were all markers stress the lung. A European Respiratory Society (ERS) International Research Seminar entitled...
Chronic granulomatous inflammation may be considered an angiogenic-dependent process. Recently it has been demonstrated that vascular endothelial growth factor (VEGF) or permeability is essential for tumour angiogenesis. Its role in inflammation-mediated angiogenesis yet to determined. In this study, the murine chronic air pouch model was used investigate of VEGF Animals were treated twice weekly with 10 μg per animal neutralizing antibody rh and vascularity granuloma dry weight assessed...
The Gen-Probe PACE 2 DNA probe assay for Neisseria gonorrhoeae was compared with conventional culture techniques in three Florida public health laboratories 436 patients (271 females and 165 males). prevalence rates based on were 19.9, 55.8, 33.5% females, males, overall, respectively. Twenty-seven probe-positive specimens gave negative results. Twenty of these resolved as true positives after retesting a competition assay. sensitivity, specificity, positive predictive value, value 99.4, 99.6, 99.6%,
Abstract We examined the cervicovaginal cytology (PAP) findings in a series of 21 endometrial and 2 cervical carcinosarcomas (CS) [malignant mixed mullerian (mesodermal) tumors] (MMMT). Initial diagnosis was positive for cancer 14 23 cases (sensitivity 61%); however, CS correctly identified only times. The remaining 12 diagnoses were carcinomas: 10 adenocarcinomas (4 endometrial, 1 cervical, 5 not otherwise specified), squamous carcinoma, poorly differentiated carcinoma. Seventeen smears...