Abstract Background Survival rates of patients with congenital diaphragmatic hernia (CDH) have improved to up 80%. Little is known about long‐term consequences the disease and its treatment. We evaluated lung function respiratory symptoms longitudinally in a previously studied cohort CDH age‐matched non‐CDH who underwent similar neonatal intensive care Study Design tested 27 young adults [mean (SD) age: 26.8 years (2.9)] 30 patients. Dynamic static volumes, midexpiratory flows, diffusion...

Short-term bowel adaptation has been documented, but data on long-term effects are scarce. The aim of the present study was to evaluate consequences infantile short syndrome (SBS). A cross-sectional assessment (2005-7) growth, nutritional status, defecation pattern and health status in individuals with a history SBS, born between 1975 2002, were performed. Data compared reference values healthy controls presented as means standard deviations or median ranges. total forty subjects (sixteen...

Growth problems are reported in patients with congenital diaphragmatic hernia during the first years of life. However, it is unknown if poor growth persists childhood. We therefore evaluated longitudinally until 12 age.This prospective study included 172 (43 treated extracorporeal membrane oxygenation [ECMO]) born from 1999 to 2014. Z scores height-for-age (HFA), weight-for-height, and distance-to-target height were calculated at 6 months age 1, 2, 5, 8, age. Data analyzed by using general...

To evaluate over a 5-yr period the feasibility and tolerance of protocol routine enteral nutrition in neonates requiring extracorporeal membrane oxygenation (ECMO).Retrospective medical chart review.Level III children's hospital, pediatric surgical intensive care unit.Neonates treated with venoarterial ECMO (VA-ECMO) between January 1997 2002. Patients congenital diaphragmatic hernia were excluded.None.Charts all VA-ECMO reviewed. Feasibility was evaluated by recording time needed for to...

Summary Background With increasing survival of patients with more severe forms congenital diaphragmatic hernia (CDH) and risk long‐term respiratory morbidity, studies on lung morphology are needed. We used hyperpolarised 3 He MRI anatomical 1 H in a cohort young adult CDH to image regional ventilation microstructure, focusing morphological micro‐structural (alveolar) abnormalities. Methods Nine left‐sided CDH, born 1975–1993, were studied. Regional was imaged MRI, the apparent diffusion...

The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and identify any effects diagnosis perinatal characteristics. 121 ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia 31 other diagnoses) performed a total 191 measurements at 5, 8 and/or 12 yrs. We assessed dynamic static volumes, reversibility airway obstruction diffusion capacity. Mean SDS forced expiratory volume in 1 s...

Objective: To evaluate lung function and respiratory morbidity prospectively during the first year of life in patients with congenital diaphragmatic hernia to study effect extracorporeal membrane oxygenation therapy. Design: Prospective longitudinal cohort study. Setting: Outpatient clinic a tertiary-level pediatric hospital. Patients: The 43 infants included 12 treated oxygenation. Evaluation was at 6 months; 33 were evaluated both time points. Interventions: None. Measurements Main...

Previous studies reported diminished growth after oesophageal atresia (OA) repair. We evaluated long-term follow-up data on growth.Longitudinal cohort study up to 12 years. Patients with OA, born 1999-2013, who participated in a longitudinal programme were included. Children genetic syndromes associated disorders excluded. SD scores (SDS) for height-for-age (HFA), weight-for-height (WFH) and distance-to-target-height calculated routine visits (0.5/1/2/5/8/12 years). Linear mixed models used...

Abstract Objective Children with congenital diaphragmatic hernia (CDH) are at risk for pulmonary morbidity. Data on longitudinal evaluation of lung function in CDH scarce. We hypothesized that patients would have impaired worsens over time. evaluated and its determinants ages 8 12 years. Methods Dynamic static volumes, diffusion capacity were measured. Extracorporeal membrane oxygenation (ECMO) treatment, the standardized European neonatal treatment protocol, patch repair, duration...

Several studies have evaluated short-term neonatal outcome in infants with congenital lung lesions (CLL) but clinical course and function the longer term not yet been documented. We hypothesized that would be negatively affected by surgical resection.To evaluate respiratory symptoms longitudinally first year of life CLL, to analyse differences herein between managed observation only whose parts were resected.We at 6 12 months 30 patients CLL. Functional residual capacity (FRC(p)) maximal...

Little is known about long‐term effects of neonatal intensive care on exercise capacity, physical activity, and fatigue in term borns. We determined these outcomes 57 young adults, treated for respiratory failure; 27 them had congenital diaphragmatic hernia with lung hypoplasia (group 1) 30 normal development 2). Patients group 2 were age‐matched, similar gestational age birth weight, treatment as patients 1. All born before the era extracorporeal membrane oxygenation, nitric oxide...

Data on long-term outcome of exercise capacity in school-aged children with esophageal atresia (EA) are scarce. We evaluated maximal and its relation to lung function. Moreover, we studied other possible determinants function.Exercise 63 EA born 1999-2007 was at the age 8 years Bruce-protocol. Dynamic static volumes, bronchodilator response diffusion were measured. Furthermore, perinatal characteristics, hospital admissions for lower respiratory tract infections (RTIs), RTIs treated...

Objectives: The objective of this study is to assess the psychopathology and medical traumatic stress in children with intestinal failure (IF) identify associated risk factors. Methods: Two-center study, performed from September 2019 until April 2022 (partly during COVID-19 pandemic), including (1.5–17 years) IF, dependent on parenteral nutrition (PN) or weaned off PN, treated by a multidisciplinary IF-team. Psychopathology was evaluated semi-structured interview assessing psychiatric...

Abstract Objectives Parent‐child interaction in pediatric intestinal failure (IF) and parenteral nutrition (PN) graduates can be disturbed due to parental responsibilities related the condition, could affect child's emotional behavioral functioning (EBF). The aim was assess parent‐child interaction, examine associations with clinical features, relate EBF. Methods A cross‐sectional study of IF patients PN aged 1.5−18 years one primary caregiver performed two Dutch multidisciplinary teams....

Objectives: The objective of this study was to gain insight into the hormonal responses enteral nutrition in critically ill newborns requiring venoarterial extracorporeal membrane oxygenation (ECMO) by analyzing plasma gut hormone levels gastrin, cholecystokinin and peptide-YY relation nutrition. Methods: In 24 consecutive neonates treated with ECMO intestinal secretions were determined radioimmunoassay at 2-day intervals. Twelve received parenteral only. 12 introduced later. findings these...

The aim of this study is to develop a tool that aligned with patients’ and health professionals’ needs address sexual in the context anorectal malformations Hirschsprung’s disease. A multiphased participatory action–research was conducted. First, an inventory made through interviews (11 patients, 11 professionals), three online focus groups (4 20 questionnaire (38 patients). Subsequently, four cocreation sessions total patients nine professionals were organized translate into (in form...

ABSTRACT Objectives: The objective of this study was to gain insight into the hormonal responses enteral nutrition in critically ill newborns requiring venoarterial extracorporeal membrane oxygenation (ECMO) by analyzing plasma gut hormone levels gastrin, cholecystokinin and peptide‐YY relation nutrition. Methods: In 24 consecutive neonates treated with ECMO intestinal secretions were determined radioimmunoassay at 2‐day intervals. Twelve received parenteral only. 12 introduced later....

Children with esophageal atresia (EA) are at risk for respiratory problems and gastro-esophageal reflux impaired physical growth. We evaluated growth longitudinally up till 8 years in patients non-syndromal EA. In 128 height weight were measured 438 times the ages 0.5, 1, 2, 5, (N = 106, 113, 101, 75 43 respectively). Parental was as well. Standard deviation scores (SDS) calculated age height; SDS corrected parental height. Height, (PHC) below norm (SDS 0) all time points (all p < 0.04). PHC...