A5010706943- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Immune cells in cancer
- RNA Research and Splicing
- RNA regulation and disease
- interferon and immune responses
University of Cologne
2022
Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation type I interferon (IFN) responses, including Aicardi-Goutières syndrome and bilateral striatal necrosis1-3. The IFN-inducible p150 isoform contains a Zα domain that recognizes alternative left-handed double-helix structure, termed Z-RNA4,5. Hemizygous mutations in IFN-mediated pathologies humans2,3 mice6-8; however, it remains unclear how interaction Z-RNA prevents IFN activation....
The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly mapped out. In mice, aging is associated with an increasing proportion peripherally, as opposed perinatally derived AMs. We sought understand AM during healthy after transplant. characterized monocyte/macrophage populations from the peripheral blood airways volunteers across infancy/childhood (2–12 yr), maturity (20–50 older adulthood (>50 yr). Single-cell RNA sequencing (scRNA-seq) was...